Top

Published in:

Open Access 01-12-2018 | Letter

Effect of intensive glycaemic control on moderate hypoglycaemia and ICU length of stay in severe traumatic brain injury

Authors: Rafael A. Núñez-Patiño, Andres Zorrilla-Vaca, Daniel Agustin Godoy

Published in: Critical Care | Issue 1/2018

Excerpt

Glycaemic alterations are prevalent and modifiable secondary insults with detrimental consequences in neurocritically ill patients. Without discerning whether hyperglycaemia is a marker of lesional severity or the cause of brain damage, its association with poor results is clear due to its deleterious effects by promoting inflammation, thrombosis of the microcirculation and immunosuppression, among others. On the other hand, both the duration and depth of an episode of hypoglycaemia have a negative influence on final outcome. Despite this, a general consensus regarding the best glycaemic control in traumatic brain injury (TBI) has not been established yet. …

Hermanides J, Plummer M, Finnis M, Deane A, Coles J, Menon D. Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis. Crit Care. 2018;22:11.CrossRefPubMedPubMedCentral

Bilotta F, Caramia R, Cernak I, Paoloni FP, Doronzio A, Cuzzone V, Santoro A, Rosa G. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care. 2008;9:159–66.CrossRefPubMed

Coester A, Neumann CR, Schmidt MI. Intensive insulin therapy in severe traumatic brain injury: a randomized trial. J Trauma. 2010;68:904–11.PubMed

Green DM, O'Phelan KH, Bassin SL, Chang CW, Stern TS, Asai SM. Intensive versus conventional insulin therapy in critically ill neurologic patients. Neurocrit Care. 2010;13:299–306.CrossRefPubMed

Finfer S, Chittock D, Li Y, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Hebert P, Henderson W, et al. Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study. Intensive Care Med. 2015;41:1037–47.CrossRefPubMed

Higgins JPT. Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol. 2008;37(5):1158–60.

Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology. 2005;64:1348-53.

Title: Effect of intensive glycaemic control on moderate hypoglycaemia and ICU length of stay in severe traumatic brain injury
Authors: Rafael A. Núñez-Patiño
Andres Zorrilla-Vaca
Daniel Agustin Godoy
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-018-2046-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effect of intensive glycaemic control on moderate hypoglycaemia and ICU length of stay in severe traumatic brain injury

Excerpt

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2018

Do we need new trials of procalcitonin-guided antibiotic therapy? A response

Postoperative cellular stress in the kidney is associated with an early systemic γδ T-cell immune cell response

The pharmacokinetic challenge of treating invasive aspergillosis complicating severe influenzae assisted by extracorporeal membrane oxygenation

Soluble programmed cell death protein-1 and programmed cell death ligand-1 in sepsis

Earplugs in the ICU: To sleep, to dream

Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit