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Open Access 01-12-2017 | Research

Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients

Authors: François Dépret, Chloé Dunyach, Christian De Tymowski, Maïté Chaussard, Aurélien Bataille, Axelle Ferry, Nabila Moreno, Alexandru Cupaciu, Sabri Soussi, Mourad Benyamina, Alexandre Mebazaa, Kevin Serror, Marc Chaouat, Jean-Pierre Garnier, Romain Pirracchio, Matthieu Legrand, for the PRONOBURN group

Published in: Critical Care | Issue 1/2017

Abstract

Background

Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently in critically ill burn patients. The aim of this study was to assess the predictive value of haptoglobin at admission to predict major adverse kidney events (MAKE) and AKI in critically ill burn patients.

Methods

We conducted a retrospective, single-centre cohort study in a burn critical care unit in a tertiary centre, including all consecutive severely burned patients (total burned body surface > 20% and/or shock and/or mechanical ventilation at admission) from January 2012 to April 2017 with a plasmatic haptoglobin dosage at admission.

Results

A total of 130 patients were included in the analysis. Their mean age was 49 (34–62) years, their median total body surface area burned was 29% (15–51%) and the intensive care unit (ICU) mortality was 25%. Early haemolysis was defined as an undetectable plasmatic haptoglobin at admission. We used logistic regression to identify MAKE and AKI risk factors. In multivariate analysis, undetectable haptoglobin was associated with MAKE and AKI (respectively, OR 6.33, 95% CI 2.34–16.45, p < 0.001; OR 8.32, 95% CI 2.86–26.40, p < 0.001).

Conclusions

Undetectable plasmatic haptoglobin at ICU admission is an independent risk factor for MAKE and AKI in critically ill burn patients. This study provides a rationale for biomarker-guided therapy using haptoglobin in critically ill burn patients.

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Title: Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients
Authors: François Dépret
Chloé Dunyach
Christian De Tymowski
Maïté Chaussard
Aurélien Bataille
Axelle Ferry
Nabila Moreno
Alexandru Cupaciu
Sabri Soussi
Mourad Benyamina
Alexandre Mebazaa
Kevin Serror
Marc Chaouat
Jean-Pierre Garnier
Romain Pirracchio
Matthieu Legrand
for the PRONOBURN group
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2017
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-017-1837-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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