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Critical Care
Published in: Critical Care 1/2017

Open Access 01-12-2017 | Viewpoint

Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?

Authors: Chih-Chung Shiao, Tao-Min Huang, Herbert D. Spapen, Patrick M. Honore, Vin-Cent Wu

Published in: Critical Care | Issue 1/2017

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Abstract

Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome.
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Metadata
Title
Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?
Authors
Chih-Chung Shiao
Tao-Min Huang
Herbert D. Spapen
Patrick M. Honore
Vin-Cent Wu
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2017
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-017-1713-2

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