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Acute kidney injury

Timing of renal replacement therapy in AKI

Nature Reviews Nephrology volume 12, pages 445–446 (2016)Cite this article

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Uncertainty exists regarding the optimal timing of initiation of renal replacement therapy in critically ill patients with acute kidney injury in the absence of urgent or life-threatening complications. Two high-profile trials — AKIKI and ELAIN — that aimed to address this issue have recently reported conflicting findings.

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Acknowledgements

S.M.B holds a Canada Research Chair in Critical Care Nephrology. The work of S.M.B and R.W. has been funded by operating grants provided by the Canadian Institutes of Health Research and the University Hospital Foundation (University of Alberta Hospital).

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Authors and Affiliations

  1. Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2–124 Clinical Sciences Building, 8440–112 ST NW, Edmonton, T6G2B7, Canada

    Sean M. Bagshaw

  2. Division of Nephrology, St. Michaels Hospital and the University of Toronto, 30 Bond St, Toronto, M5B 1W8, Ontario, Canada

    Ron Wald

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  1. Sean M. Bagshaw
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Correspondence to Sean M. Bagshaw.

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Competing interests

S.M.B and R.W. are co-principal investigators of the Standard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial, an international multicentre randomized clinical trial comparing pre-emptive renal replacement therapy initiation versus a strategy of watchful waiting in critically ill patients with acute kidney injury (https://clinicaltrials.gov/ct2/show/NCT02568722). The work of S.M.B and R.W. is supported by an unrestricted research grant from Baxter.

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Bagshaw, S., Wald, R. Timing of renal replacement therapy in AKI. Nat Rev Nephrol 12, 445–446 (2016). https://doi.org/10.1038/nrneph.2016.92

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