Published in:
Open Access
01-12-2017 | Letter
A brief comment on vaccinations for opportunistic microorganisms
Authors:
Ferhat Arslan, Haluk Vahaboğlu
Published in:
Critical Care
|
Issue 1/2017
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Excerpt
We read with interest the manuscript by Rello et al. published in
Critical Care [
1]. The authors conducted a randomized, placebo-controlled vaccine study against
Pseudomonas aeruginosa among intensive care unit (ICU) patients and concluded that vaccination against
P. aeruginosa failed to protect the patients from infection with this microorganism. Interestingly, invasive
P. aeruginosa infections were more common among the vaccinated population (vaccinated, 39/263; placebo, 6/92; risk ratio (RR) 1.169; 95% confidence interval (CI) 1.027–1.332; one-sided Fischer’s exact test,
p = 0.042; Stata 13.1). …