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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Research

Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients

Authors: Cassianne Robinson-Cohen, Ronit Katz, Brenda L. Price, Susanna Harju-Baker, Carmen Mikacenic, Jonathan Himmelfarb, W. Conrad Liles, Mark M. Wurfel

Published in: Critical Care | Issue 1/2016

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Abstract

Background

The role of endothelial dysregulation with acute kidney injury (AKI) in critically ill patients is unclear.

Methods

We retrospectively assessed the associations of AKI with biomarkers of endothelial function and inflammation among 948 subjects admitted to the intensive care unit (ICU) at Harborview Medical Center (Seattle, WA, USA). From plasma obtained within 24 h of enrollment, we measured angiopoietin (Ang)-1 and Ang-2 alongside biomarkers of inflammation, including interleukin (IL)-6, IL-17 and granulocyte colony-stimulating factor. We tested for associations between standardized concentrations of biomarkers and AKI, defined by serum creatinine, from ICU admission to up to 7 days later.

Results

All biomarkers of inflammation and endothelial dysfunction were associated with AKI. After adjustment for demographics, comorbidities, and IL-6 concentration, every standard deviation of Ang-1 concentration was associated with a 19 % lower risk of AKI (relative risk (RR) = 0.85, 95 % confidence interval (CI) 0.77–0.93, p < 0.001). Conversely, higher Ang-2 concentration was associated with higher risk of AKI (RR per standard deviation = 1.17, 95 % CI 1.13–1.22, p < 0.001).

Conclusions

In critically ill patients, plasma concentration of the endothelial growth factors Ang-1 and Ang-2 are associated with AKI, independently of inflammation.
Appendix
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Metadata
Title
Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients
Authors
Cassianne Robinson-Cohen
Ronit Katz
Brenda L. Price
Susanna Harju-Baker
Carmen Mikacenic
Jonathan Himmelfarb
W. Conrad Liles
Mark M. Wurfel
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1385-3

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