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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Letter

Dialysis with high-flux membranes significantly affects plasma levels of neutrophil gelatinase-associated lipocalin

Author: Carlo Donadio

Published in: Critical Care | Issue 1/2016

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Excerpt

I read with interest the recent article by Schilder et al. reporting that plasma levels and the biomarker value of neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with acute kidney injury (AKI) are not affected by continuous venovenous hemofiltration (CVVH) [1]. Recently, Honore et al. [2] commented on the data by Schilder et al., suggesting that further studies are warranted to definitely assess the membranes and the dialytic techniques that can remove NGAL from plasma and thus affect its accuracy as a marker of AKI. …
Literature
1.
Schilder L, Nurmohamed SA, ter Wee PM, Paauw NJ, Girbes AR, Beishuizen A, et al. The plasma level and biomarker value of neutrophil gelatinase-associated lipocalin in critically ill patients with acute kidney injury are not affected by continuous venovenous hemofiltration and anticoagulation applied. Crit Care. 2014;18:R78.CrossRefPubMedPubMedCentral
2.
Honore PM, Jacobs R, Hendrickx I, De Waele E, Van Gorp V, Spapen HD. Is neutrophil gelatinase-associated lipocalin unaffected by convective continuous renal replacement therapy? Definitely…maybe. Crit Care. 2015;19:392.CrossRefPubMedPubMedCentral
3.
Donadio C. Effect of glomerular filtration rate impairment on diagnostic performance of neutrophil gelatinase-associated lipocalin and B-type natriuretic peptide as markers of acute cardiac and renal failure in chronic kidney disease patients. Crit Care. 2014;18:R39.CrossRefPubMedPubMedCentral
Metadata
Title
Dialysis with high-flux membranes significantly affects plasma levels of neutrophil gelatinase-associated lipocalin
Author
Carlo Donadio
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1198-4

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