Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2015

01-12-2015 | Review

Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ARDS

Authors: Philippe Morimont, Andriy Batchinsky, Bernard Lambermont

Published in: Critical Care | Issue 1/2015

Login to get access

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://​ccforum.​com/​series/​annualupdate2015​. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://​www.​springer.​com/​series/​8901.
Literature
1.
The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301–8.
2.
Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest. 2008;133:1120–7.PubMed
3.
Squara P, Dhainaut JF, Artigas A, Carlet J. Hemodynamic profile in severe ARDS: results of the European Collaborative ARDS Study. Intensive Care Med. 1998;24:1018–28.PubMed
4.
Gajic O, Dabbagh O, Park PK, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011;183:462–70.PubMed
5.
Cancio LC, Batchinsky AI, Dubick MA, et al. Inhalation injury: pathophysiology and clinical care proceedings of a symposium conducted at the Trauma Institute of San Antonio, San Antonio, TX, USA on 28 March 2006. Burns. 2007;33:681–92.PubMed
6.
Lheritier G, Legras A, Caille A, et al. Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with early acute respiratory distress syndrome: a multicenter study. Intensive Care Med. 2013;39:1734–42.PubMed
7.
Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med. 2013;369:2126–36.PubMed
8.
Ijland MM, Heunks LM, van der Hoeven JG. Bench-to-bedside review: hypercapnic acidosis in lung injury – from ‘permissive’ to ‘therapeutic’. Crit Care. 2010;14:237.PubMed
9.
Terragni PP, Rosboch G, Tealdi A, et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2007;175:160–6.PubMed
10.
Hager DN, Krishnan JA, Hayden DL, Brower RG. Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med. 2005;172:1241–5.PubMedPubMedCentral
11.
Brochard L, Roudot-Thoraval F, Roupie E, et al. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med. 1998;158:1831–8.PubMed
12.
Pesenti A, Pelizzola A, Mascheroni D, et al. Low frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R) in acute respiratory failure (ARF): technique. Trans Am Soc Artif Intern Organs. 1981;27:263–6.PubMed
13.
Batchinsky AI, Jordan BS, Regn D, et al. Respiratory dialysis: reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal. Crit Care Med. 2011;39:1382–7.PubMed
14.
Batchinsky AI, Chung K, Cannon J, Cancio LC. Respiratory dialysis is not extracorporeal membrane oxygenation. The authors answer. Extracorporeal membrane oxygenation and respiratory dialysis: our expending tool box. Crit Care Med. 2011;39:2788–9.
15.
Terragni PP, Del Sorbo L, Mascia L, et al. Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal. Anesthesiology. 2009;111:826–35.PubMed
16.
Feihl F, Perret C. Permissive hypercapnia. How permissive should we be? Am J Respir Crit Care Med. 1994;150:1722–37.PubMed
17.
Laffey JG, Kavanagh BP. Carbon dioxide and the critically ill – too little of a good thing? Lancet. 1999;354:1283–6.PubMed
18.
O’Croinin D, Ni Chonghaile M, Higgins B, Laffey JG. Bench-to-bedside review: permissive hypercapnia. Crit Care. 2005;9:51–9.PubMed
19.
Vadasz I, Hubmayr RD, Nin N, Sporn PH, Sznajder JI. Hypercapnia: a nonpermissive environment for the lung. Am J Respir Cell Mol Biol. 2012;46:417–21.PubMedPubMedCentral
20.
Curley G, Contreras MM, Nichol AD, Higgins BD, Laffey JG. Hypercapnia and acidosis in sepsis: a double-edged sword? Anesthesiology. 2010;112:462–72.PubMed
21.
Nichol AD, O’Cronin DF, Howell K, et al. Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis. Crit Care Med. 2009;37:2953–61.PubMed
22.
Briva A, Vadasz I, Lecuona E, et al. High CO2 levels impair alveolar epithelial function independently of pH. PLoS One. 2007;2:e1238.PubMedPubMedCentral
23.
Stengl M, Ledvinova L, Chvojka J, et al. Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study. Crit Care. 2013;17:R303.PubMedPubMedCentral
24.
Morimont P, Lambermont B, Ghuysen A, et al. Effective arterial elastance as an index of pulmonary vascular load. Am J Physiol Heart Circ Physiol. 2008;294:H2736–42.PubMed
25.
Viitanen A, Salmenpera M, Heinonen J. Right ventricular response to hypercarbia after cardiac surgery. Anesthesiology. 1990;73:393–400.PubMed
26.
Sagawa KML, Suga H, Sunagawa K. Cardiovascular interaction. In: Sagawa K, editor. Cardiac Contraction and the Pressure–Volume Relationship. New York: Oxford University Press; 1988. p. 232–98.
27.
Morimont P, Lambermont B, Desaive T, et al. Right ventriculoarterial coupling in acute respiratory distress syndrome (ARDS) and expected benefits of CO2 removal therapy. J Crit Care. 2013;28:e30.
28.
Weber T, Tschernich H, Sitzwohl C, et al. Tromethamine buffer modifies the depressant effect of permissive hypercapnia on myocardial contractility in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2000;162:1361–5.PubMed
29.
Kolobow T, Gattinoni L, Tomlinson T, Pierce JE. An alternative to breathing. J Thorac Cardiovasc Surg. 1978;75:261–6.PubMed
30.
Gattinoni L, Agostoni A, Pesenti A, et al. Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2. Lancet. 1980;2:292–4.PubMed
31.
Terragni P, Maiolo G, Ranieri VM. Role and potentials of low-flow CO(2) removal system in mechanical ventilation. Curr Opin Crit Care. 2012;18:93–8.PubMed
32.
Pesenti A, Patroniti N, Fumagalli R. Carbon dioxide dialysis will save the lung. Crit Care Med. 2010;38:S549–54.PubMed
33.
Peek GJ, Mugford M, Tiruvoipati R, et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet. 2009;374:1351–63.PubMed
34.
Del Sorbo L, Ranieri VM. We do not need mechanical ventilation any more. Crit Care Med. 2010;38:S555–8.PubMed
35.
Barrett KBS, Boitano S, Brooks H. Ganong’s Review of Medical Physiology. 23rd ed. New York: Mc Graw Hill; 2003. p. 587–607.
36.
Park M, Costa EL, Maciel AT, et al. Determinants of oxygen and carbon dioxide transfer during extracorporeal membrane oxygenation in an experimental model of multiple organ dysfunction syndrome. PLoS One. 2013;8:e54954.PubMedPubMedCentral
37.
Toomasian JM, Schreiner RJ, Meyer DE. A polymethylpentene fiber gas exchanger for long-term extracorporeal life support. ASAIO J. 2005;51:390–7.PubMed
38.
Morimont P, Desaive T, Guiot J, et al. Effects of veno-venous CO2 removal therapy on pulmonary circulation in an ARDS model. Intensive Care Med Exp. 2014;2:45.
39.
Scaravilli V, Kreyer S, Linden K, et al. Modular extracorporeal life support: effects of ultrafiltrate recirculation on the performance of an extracorporeal carbon dioxide removal device. ASAIO J. 2014;60:335–41.PubMed
40.
Zanella A, Mangili P, Giani M, et al. Extracorporeal carbon dioxide removal through ventilation of acidified dialysate: an experimental study. J Heart Lung Transplant. 2014;33:536–41.PubMed
41.
Cove ME, MacLaren G, Federspiel WJ, Kellum JA. Bench to bedside review: extracorporeal carbon dioxide removal, past present and future. Crit Care. 2012;16:232.PubMedPubMedCentral
42.
Bein T, Weber-Carstens S, Goldmann A, et al. Lower tidal volume strategy (approximately 3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study. Intensive Care Med. 2013;39:847–56.PubMedPubMedCentral
43.
Forster C, Schriewer J, John S, Eckardt KU, Willam C. Low-flow CO(2) removal integrated into a renal-replacement circuit can reduce acidosis and decrease vasopressor requirements. Crit Care. 2013;17:R154.PubMedPubMedCentral
44.
Rousseau AF, Damas P, Renwart L. Use of a pediatric oxygenator integrated in a veno-venous hemofiltration circuit to remove CO: A case report in a severe burn patient with refractory hypercapnia. Burns. 2014;40:e47–50.
45.
Fitzgerald M, Millar J, Blackwood B, et al. Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: a systematic review. Crit Care. 2014;18:222.PubMedPubMedCentral
46.
Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307:2526–33.PubMed
47.
Cardenas Jr VJ, Miller L, Lynch JE, Anderson MJ, Zwischenberger JB. Percutaneous venovenous CO2 removal with regional anticoagulation in an ovine model. ASAIO J. 2006;52:467–70.PubMed
48.
Larsson M, Rayzman V, Nolte MW, et al. A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk. Sci Transl Med. 2014;6:222ra17.PubMed
Metadata
Title
Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ARDS
Authors
Philippe Morimont
Andriy Batchinsky
Bernard Lambermont
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-0799-7

Other articles of this Issue 1/2015

Critical Care 1/2015 Go to the issue

Research

Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis

Research

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation

Letter

Is lactate clearance impaired in septic shock?

Research

Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial

Research

Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients

Review

Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review