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Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Letter

Is lactate clearance impaired in septic shock?

Authors: Thiago Domingos Corrêa, Jukka Takala, Stephan Matthias Jakob

Published in: Critical Care | Issue 1/2015

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Excerpt

In a recent article in Critical Care, Tapia and colleagues evaluated the relationship between exogenous lactate clearance and liver perfusion in a short-term model of endotoxemic shock [1]. The authors concluded that the very low portal-hepatic vein lactate gradient was indicative of the inability of the liver to metabolize the increased lactate load. Although we believe that the authors addressed an important issue, we have some concerns regarding their methodology. …
Literature
1.
Tapia P, Soto D, Bruhn A, Alegria L, Jarufe N, Luengo C, et al. Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion. Crit Care. 2015;19:188.CrossRef
2.
Barthelmes D, Jakob SM, Laitinen S, Rahikainen S, Ahonen H, Takala J. Effect of site of lactate infusion on regional lactate exchange in pigs. Br J Anaesth. 2010;105:627–34.CrossRef
3.
Gorrasi J, Eleftheriadis A, Takala J, Brandt S, Djafarzadeh S, Bruegger LE, et al. Different contribution of splanchnic organs to hyperlactatemia in fecal peritonitis and cardiac tamponade. Biomed Res Int. 2013;2013:251084.CrossRef
4.
Connor H, Woods HF, Ledingham JG, Murray JD. A model of L(+)-lactate metabolism in normal man. Ann Nutr Metab. 1982;26:254–63.CrossRef
5.
Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, et al. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med. 1998;157:1021–6.CrossRef
Metadata
Title
Is lactate clearance impaired in septic shock?
Authors
Thiago Domingos Corrêa
Jukka Takala
Stephan Matthias Jakob
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1039-x

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