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Critical Care
Published in: Critical Care 5/2014

Open Access 01-10-2014 | Commentary

Circulating cytokines in predicting development of severe acute pancreatitis

Author: Ori D Rotstein

Published in: Critical Care | Issue 5/2014

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Abstract

Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials.
Literature
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Nieminen A, Maksimow M, Mentula P, Kyhälä L, Kylänpää L, Puolakkainen P, Kemppainen E, Repo H, Salmi M: Circulating cytokines in predicting development of severe acute pancreatitis. Crit Care. 2014, 18: R104-10.1186/cc13885.PubMedCrossRef
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Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS: Classification of acute pancreatitis-2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013, 62: 102-111. 10.1136/gutjnl-2012-302779.PubMedCrossRef
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Zhang J, Niu J, Yang J: Interleukin-6, interleukin-8 and interleukin-10 in estimating the severity of acute pancreatitis: an updated meta-analysis. Hepatogastroenterology. 2014, 61: 215-220.PubMed
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Leser HG, Gross V, Scheibenbogen C, Heinisch A, Salm R, Lausen M, Rückauer K, Andreesen R, Farthmann EH, Schölmerich J: Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. Gastroenterology. 1991, 101: 782-785.PubMed
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Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H: Il-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest. 2013, 123: 1019-1031. 10.1172/JCI64931.PubMedCrossRef
Metadata
Title
Circulating cytokines in predicting development of severe acute pancreatitis
Author
Ori D Rotstein
Publication date
01-10-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0575-0

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