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Critical Care
Published in: Critical Care 4/2014

Open Access 01-08-2014 | Viewpoint

Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization

Authors: Catherine Chen, Marin H Kollef

Published in: Critical Care | Issue 4/2014

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Abstract

Intravenous fluids (IVFs) represent a basic therapeutic intervention utilized in septic shock. Unfortunately, the optimal method for administering IVFs to maximize patient outcomes is unknown. A meta-analysis of four randomized trials of goal-directed therapy did not demonstrate a significant reduction in mortality (odds ratio 0.609; 95% confidence interval 0.363 to 1.020; P = 0.059), whereas 18 trials with historical controls showed a significant increase in survival (odds ratio 0.580; 95% confidence interval 0.501 to 0.672; P < 0.0001). Based on these data, clinicians should be aware of the potential for harm due to the excessive administration of IVFs to patients with septic shock.
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Metadata
Title
Conservative fluid therapy in septic shock: an example of targeted therapeutic minimization
Authors
Catherine Chen
Marin H Kollef
Publication date
01-08-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0481-5

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