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Open Access 01-12-2019 | Bronchial Asthma | Letter to the Editor

Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice

Authors: Amelia Licari, Dietmar Fuchs, Gianluigi Marseglia, Giorgio Ciprandi

Published in: Italian Journal of Pediatrics | Issue 1/2019

Abstract

Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.

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Title: Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice
Authors: Amelia Licari
Dietmar Fuchs
Gianluigi Marseglia
Giorgio Ciprandi
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Bronchial Asthma
Published in: Italian Journal of Pediatrics / Issue 1/2019
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-019-0699-6

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Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice

Abstract

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