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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2017

Open Access 01-12-2017 | Review

Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology

Authors: Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi

Published in: Italian Journal of Pediatrics | Issue 1/2017

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Abstract

This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated. New diagnostic tools are available for ascertaining brucellosis, celiac disease and viral infections. The usefulness of aCGH as first-tier test is confirmed in patients with neurodevelopmental disorders. Novel information have been provided on the safety of milk for infants. Recent advances in the treatment of common disorders, including neonatal respiratory distress syndrome, hypo-glycemia in newborns, atopic dermatitis, constipation, cyclic vomiting syndrome, nephrotic syndrome, diabetes mellitus, regurgitation, short stature, secretions in children with cerebral palsy have been reported. Antipyretics treatment has been updated by national guidelines and studies have excluded side effects (e.g. asthma risk during acetaminophen therapy). Vaccinations are a painful event and several options are reported to prevent this pain. Adverse effects due to metabolic abnormalities are reported for second generation antipsychotic drugs.
Literature
1.
Mastrorilli C, Posa D, Cipriani F, Caffarelli C. Asthma and allergic rhinitis in childhood: what's new. Pediatr Allergy Immunol. 2016;27:795–803.CrossRefPubMed
2.
Montella S, Baraldi E, Cazzato S, Aralla R, Berardi M, Brunetti LM, et al. Severe asthma features in children: a case-control online survey. Ital J Pediatr. 2016;42:9.CrossRefPubMedPubMedCentral
3.
Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011;127:9 e1–13.
4.
Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43:343–73.
5.
6.
Caffarelli C, Dascola CP, Peroni D, Ricò S, Stringari G, Varini M, et al. Airway acidification in childhood asthma exacerbations. Allergy Asthma Proc. 2014;35:51–6.CrossRefPubMed
7.
Esfandiar N, Alaei F, Fallah S, Babaie D, Sedghi N. Vitamin D deficiency and its impact on asthma severity in asthmatic children. Ital J Pediatr. 2016;42:108.CrossRefPubMedPubMedCentral
8.
Kerley CP, Hutchinson K, Cormican L, Faul J, Greally P, Coghlan D, et al. Vitamin D3 for uncontrolled childhood asthma: a pilot study. Pediatr Allergy Immunol. 2016;27:404–12.CrossRefPubMed
9.
Tachimoto H, Mezawa H, Segawa T, Akiyama N, Ida H, Urashima M. Improved control of childhood asthma with low-dose, short-term vitamin D supplementation: a randomized, double-blind, placebo-controlled trial. Allergy. 2016;71:1001–9.CrossRefPubMed
10.
Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311:2083–91.CrossRefPubMedPubMedCentral
11.
Galli E, Neri I, Ricci G, Baldo E, Barone M, Belloni Fortina A, et al. Consensus conference on clinical management of pediatric atopic dermatitis. Ital J Pediatr. 2016;42:26.CrossRefPubMedPubMedCentral
12.
Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387:1109–22.
13.
Di Rienzo V, Cadario G, Grieco T, Galluccio AG, Caffarelli C, Liotta G, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, open, parallel-group study. Ann Allergy Asthma Immunol. 2014;113:671–3 e1.CrossRefPubMed
14.
Savino F, Viola S, Tarasco V, Locatelli E, Ricagni A, Coppo P. Neonatal lupus erythematosus: a cutaneous cases based update. Ital J Pediatr. 2016;42:1.CrossRefPubMedPubMedCentral
15.
Fatemi A, Matinfar M, Saber M, Smiley A. The association between initial manifestations of childhood-onset systemic lupus erythematosus and the survival. Int J Rheum Dis. 2016;19:974–80.CrossRefPubMed
16.
Lima GL, Paupitz J, Aikawa NE, Takayama L, Bonfa E, Pereira RM. Vitamin D supplementation in adolescents and young adults with juvenile systemic lupus erythematosus for improvement in disease activity and fatigue scores: a randomized, double-blind, placebo-controlled trial. Arthritis Care Res (Hoboken). 2016;68:91–8.CrossRef
17.
Hoyme HE, Coles CD. Alcohol-related neurobehavioral disabilities: need for further definition and common terminology. Pediatrics. 2016;138.
18.
Hagan JF Jr, Balachova T, Bertrand J, Chasnoff I, Dang E, Fernandez-Baca D, et al. Neurobehavioral disorder associated with prenatal alcohol exposure. Pediatrics. 2016;138.
19.
Wen Z, Yu D, Zhang W, Fan C, Hu L, Feng Y, et al. Association between alcohol consumption during pregnancy and risks of congenital heart defects in offspring: meta-analysis of epidemiological observational studies. Ital J Pediatr. 2016;42:12.CrossRefPubMedPubMedCentral
20.
Sun J, Chen X, Chen H, Ma Z, Zhou J. Maternal alcohol consumption before and during pregnancy and the risks of congenital heart defects in offspring: a systematic review and meta-analysis. Congenit Heart Dis. 2015;10:E216–24.CrossRefPubMed
21.
Tang Y, Gao X, Shen J, Sun L, Yan W. Epidemiological and clinical characteristics of Kawasaki disease and factors associated with coronary artery abnormalities in East China: nine years experience. J Trop Pediatr. 2016;62:86–93.CrossRefPubMedPubMedCentral
22.
23.
Lee MN, Cha JH, Ahn HM, Yoo JH, Kim HS, Sohn S, et al. Mycoplasma pneumoniae infection in patients with Kawasaki disease. Korean J Pediatr. 2011;54:123–7.CrossRefPubMedPubMedCentral
24.
Strambi M, Giussani M, Ambruzzi MA, Brambilla P, Corrado C, Giordano U, et al. Novelty in hypertension in children and adolescents: focus on hypertension during the first year of life, use and interpretation of ambulatory blood pressure monitoring, role of physical activity in prevention and treatment, simple carbohydrates and uric acid as risk factors. Ital J Pediatr. 2016;42:69.CrossRefPubMedPubMedCentral
25.
Cantinotti M, Giordano R, Scalese M, Molinaro S, Murzi B, Assanta N, et al. Strengths and limitations of current pediatric blood pressure nomograms: a global overview with a special emphasis on regional differences in neonates and infants. Hypertens Res. 2015;38:577–87.CrossRefPubMed
26.
Dionne JM, Abitbol CL, Flynn JT. Erratum to: hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol. 2012;27:159–60.CrossRef
27.
Caffarelli C, Ricò S, Rinaldi L, Povesi Dascola C, Terzi C, Bernasconi S. Blood pressure monitoring in children undergoing food challenge: association with anaphylaxis. Ann Allergy Asthma Immunol. 2012;108:285–6.CrossRefPubMed
28.
Semlitsch T, Jeitler K, Hemkens LG, Horvath K, Nagele E, Schuermann C, et al. Increasing physical activity for the treatment of hypertension: a systematic review and meta-analysis. Sports medicine (Auckland, NZ). 2013;43:1009–23.CrossRef
29.
Kropa J, Close J, Shipon D, Hufnagel E, Terry C, Oliver J, et al. High prevalence of obesity and high blood pressure in urban student-athletes. J Pediatr. 2016;178:194–9.CrossRefPubMed
30.
31.
Kim HS, Lee MK. Beta-cell regeneration through the transdifferentiation of pancreatic cells: pancreatic progenitor cells in the pancreas. J Diabetes Investig. 2016;7:286–96.CrossRefPubMedPubMedCentral
32.
Polymeri A, Giannobile WV, Kaigler D. Bone marrow stromal stem cells in tissue engineering and regenerative medicine. Horm Metab Res. 2016;48:700–13.CrossRefPubMed
33.
34.
Iughetti L, Tornese G, Street ME, Napoli F, Giavoli C, Antoniazzi F, et al. Long-term safety and efficacy of Omnitrope(R), a somatropin biosimilar, in children requiring growth hormone treatment: Italian interim analysis of the PATRO children study. Ital J Pediatr. 2016;42:93.CrossRefPubMedPubMedCentral
35.
36.
Borras Perez V, Lopez-Siguero JP, Martinez G, Corripio R, Fernandez JM, Labarta JI, et al. A follow-up study to monitor adult height among Spanish children with growth hormone deficiency who received biosimilar human recombinant growth hormone (Omnitrope(R)) during a phase III clinical trial. Adv Ther. 2015;32:148–56.CrossRefPubMedPubMedCentral
37.
Counts DR, Silverman LA, Rajicic N, Geffner ME, Newfield RS, Thornton P, et al. A 4-year, open-label, multicenter, randomized trial of Genotropin(R) growth hormone in patients with idiopathic short stature: analysis of 4-year data comparing efficacy, efficiency, and safety between an individualized, target-driven regimen and standard dosing. Horm Res Paediatr. 2015;84:79–87.CrossRefPubMed
38.
39.
Di Tola M, Marino M, Casale R, Di Battista V, Borghini R, Picarelli A. Extension of the celiac intestinal antibody (CIA) pattern through eight antibody assessments in fecal supernatants from patients with celiac disease. Immunobiology. 2016;221:63–9.CrossRefPubMed
40.
Khatib M, Baker RD, Ly EK, Kozielski R, Baker SS. Presenting pattern of pediatric celiac disease. J Pediatr Gastroenterol Nutr. 2016;62:60–3.CrossRefPubMed
41.
Calderoni S, Santocchi E, Del Bianco T, Brunori E, Caponi L, Paolicchi A, et al. Serological screening for celiac disease in 382 pre-schoolers with autism spectrum disorder. Ital J Pediatr. 2016;42:98.CrossRefPubMedPubMedCentral
42.
Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S, et al. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med. 2010;42:587–95.CrossRefPubMed
43.
Benjilali L, Zahlane M, Essaadouni L. A migraine as initial presentation of celiac disease. Rev Neurol (Paris). 2012;168:454–6.CrossRef
44.
Nenna R, Petrarca L, Verdecchia P, Florio M, Pietropaoli N, Mastrogiorgio G, et al. Celiac disease in a large cohort of children and adolescents with recurrent headache: a retrospective study. Dig Liver Dis. 2016;48:495–8.CrossRefPubMed
45.
Nenna R, Tiberti C, Petrarca L, Lucantoni F, Mennini M, Luparia RP, et al. The celiac iceberg: characterization of the disease in primary schoolchildren. J Pediatr Gastroenterol Nutr. 2013;56:416–21.CrossRefPubMed
46.
Le Gal J, Michel JF, Rinaldi VE, Spiri D, Moretti R, Bettati D, et al. Association between functional gastrointestinal disorders and migraine in children and adolescents: a case-control study. Lancet Gastroenterol Hepatol. 2016;1:114–21.CrossRefPubMed
47.
Salvatore S, Barberi S, Borrelli O, Castellazzi A, Di Mauro D, Di Mauro G, et al. Pharmacological interventions on early functional gastrointestinal disorders. Ital J Pediatr. 2016;42:68.CrossRefPubMedPubMedCentral
48.
Caffarelli C, Coscia A, Baldi F, Borghi A, Capra L, Cazzato S, et al. Characterization of irritable bowel syndrome and constipation in children with allergic diseases. Eur J Pediatr. 2007;166:1245–52.CrossRefPubMed
49.
Madani S, Cortes O, Thomas R. Cyproheptadine use in children with functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2016;62:409–13.CrossRefPubMed
50.
Aktar F, Tekin R, Bektas MS, Gunes A, Kosker M, Ertugrul S, et al. Diagnostic role of inflammatory markers in pediatric Brucella arthritis. Ital J Pediatr. 2016;42:3.CrossRefPubMedPubMedCentral
51.
Karaman K, Akbayram S, Bayhan GI, Dogan M, Parlak M, Akbayram HT, et al. Hematologic findings in children with brucellosis: experiences of 622 patients in eastern Turkey. J Pediatr Hematol Oncol. 2016;38:463–6.CrossRefPubMed
52.
van Houten CB, de Groot JAH, Klein A, Srugo I, Chistyakov I, de Waal W, et al. A host-protein based assay to differentiate between bacterial and viral infections in preschool children (OPPORTUNITY): a double-blind, multicentre, validation study. Lancet Infect Dis. 2017;17:431–40.CrossRefPubMed
53.
Cebey-Lopez M, Herberg J, Pardo-Seco J, Gomez-Carballa A, Martinon-Torres N, Salas A, et al. Does viral co-infection influence the severity of acute respiratory infection in children? PLoS One. 2016;11:e0152481.CrossRefPubMedPubMedCentral
54.
Chiappini E, Venturini E, Remaschi G, Principi N, Longhi R, Tovo P-A, et al. 2016 update of the Italian pediatric society guidelines for Management of Fever in children. J Pediatr. 2017;180:177–83.e1.CrossRefPubMed
55.
Martins M, Abecasis F. Healthcare professionals approach paediatric fever in significantly different ways and fever phobia is not just limited to parents. Acta Paediatr. 2016;105:829–33.CrossRefPubMed
56.
Lubrano R, Paoli S, Bonci M, Di Ruzza L, Cecchetti C, Falsaperla R, et al. Acetaminophen administration in pediatric age: an observational prospective cross-sectional study. Ital J Pediatr. 2016;42:20.CrossRefPubMedPubMedCentral
57.
Mayor S. Paracetamol is no more likely to exacerbate asthma in children than ibuprofen, shows study. BMJ. 2016;354:i4558.CrossRefPubMed
58.
59.
60.
Rebelo Pacheco S, Abadesso C, Monteiro A, Taddio A. Pain management during childhood vaccination injections in Portugal - a call to action. Acta Paediatr. 2016;105:e338.CrossRefPubMed
61.
Karaca Ciftci E, Kardas Ozdemir F, Aydin D. Effect of flick application on pain level and duration of crying during infant vaccination. Ital J Pediatr. 2016;42:8.CrossRefPubMedPubMedCentral
62.
Harrison D, Reszel J, Bueno M, Sampson M, Shah VS, Taddio A, et al. Breastfeeding for procedural pain in infants beyond the neonatal period. Cochrane Database Syst Rev. 2016;10:CD011248.PubMed
63.
Da Dalt L, Zerbinati C, Strafella MS, Renna S, Riceputi L, Di Pietro P, et al. Henoch-Schonlein purpura and drug and vaccine use in childhood: a case-control study. Ital J Pediatr. 2016;42:60.CrossRefPubMedPubMedCentral
64.
Tiberi E, Cota F, Barone G, Perri A, Romano V, Iannotta R, et al. Continuous glucose monitoring in preterm infants: evaluation by a modified Clarke error grid. Ital J Pediatr. 2016;42:29.CrossRefPubMedPubMedCentral
65.
Hegarty JE, Harding JE, Gamble GD, Crowther CA, Edlin R, Alsweiler JM. Prophylactic oral dextrose gel for newborn babies at risk of neonatal hypoglycaemia: a randomised controlled dose-finding trial (the pre-hPOD study). PLoS Med. 2016;13:e1002155.
66.
Harris DL, Alsweiler JM, Ansell JM, Gamble GD, Thompson B, Wouldes TA, et al. Outcome at 2 years after dextrose gel treatment for neonatal hypoglycemia: follow-up of a randomized trial. J Pediatr. 2016;170:9 e1–2.
67.
Harris DL, Weston PJ, Signal M, Chase JG, Harding JE. Dextrose gel for neonatal hypoglycaemia (the sugar babies study): a randomised, double-blind, placebo-controlled trial. Lancet. 2013;382:2077–83.CrossRefPubMed
68.
Dehdashtian M, Malakian A, Aramesh MR, Mazori A, Aletayeb MH, Shirani A, et al. Effectiveness of intratracheal salbutamol in addition to surfactant on the clinical course of newborns with respiratory distress syndrome: a clinical trial. Ital J Pediatr. 2016;42:6.CrossRefPubMedPubMedCentral
69.
Roberts CT, Owen LS, Manley BJ, Froisland DH, Donath SM, Dalziel KM, et al. Nasal high-flow therapy for primary respiratory support in preterm infants. N Engl J Med. 2016;375:1142–51.CrossRefPubMed
70.
Mascoll-Robertson KK, Viscardi RM, Woo HC. The objective use of pulse oximetry to predict respiratory support transition in preterm infants: an observational pilot study. Respir Care. 2016;61:416–22.CrossRefPubMed
71.
Cantey JB, Wozniak PS, Pruszynski JE, Sanchez PJ. Reducing unnecessary antibiotic use in the neonatal intensive care unit (SCOUT): a prospective interrupted time-series study. Lancet Infect Dis. 2016;16:1178–84.CrossRefPubMed
72.
73.
Lombel RM, Gipson DS, Hodson EM. Kidney disease: improving global outcomes. Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO Pediatr Nephrol. 2013;28:415–26.PubMed
74.
Larkins N, Kim S, Craig J, Hodson E. Steroid-sensitive nephrotic syndrome: an evidence-based update of immunosuppressive treatment in children. Arch Dis Child. 2016;101:404–8.CrossRefPubMed
75.
Maratea D, Bettio M, Corti MG, Montini G, Venturini F. The efficacy and safety of rituximab in treating childhood nephrotic syndrome: an Italian perspective. Ital J Pediatr. 2016;42:63.CrossRefPubMedPubMedCentral
76.
Artoni A, Passamonti SM, Edefonti A, Gianniello F, Civelli V, Martinelli I. Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency. Ital J Pediatr. 2016;42:22.CrossRefPubMedPubMedCentral
77.
Gangakhedkar A, Wong W, Pitcher LA. Cerebral thrombosis in childhood nephrosis. J Paediatr Child Health. 2005;41:221–4.CrossRefPubMed
78.
Andrew M, David M, Adams M, Ali K, Anderson R, Barnard D, et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian registry of VTE. Blood. 1994;83:1251–7.PubMed
79.
Hoyer PF, Gonda S, Barthels M, Krohn HP, Brodehl J. Thromboembolic complications in children with nephrotic syndrome. Risk and incidence Acta Paediatr Scand. 1986;75:804–10.CrossRefPubMed
80.
Pisano S, Catone G, Veltri S, Lanzara V, Pozzi M, Clementi E, et al. Update on the safety of second generation antipsychotics in youths: a call for collaboration among paediatricians and child psychiatrists. Ital J Pediatr. 2016;42:51.CrossRefPubMedPubMedCentral
81.
De Hert M, Dobbelaere M, Sheridan EM, Cohen D, Correll CU. Metabolic and endocrine adverse effects of second-generation antipsychotics in children and adolescents: a systematic review of randomized, placebo controlled trials and guidelines for clinical practice. Eur Psychiatry. 2011;26:144–58.CrossRefPubMed
82.
Broussard AB, Borazjani JG. The faces of Moebius syndrome: recognition and anticipatory guidance. MCN Am J Matern Child Nurs. 2008;33:272–8.CrossRefPubMed
83.
Picciolini O, Porro M, Cattaneo E, Castelletti S, Masera G, Mosca F, et al. Moebius syndrome: clinical features, diagnosis, management and early intervention. Ital J Pediatr. 2016;42:56.CrossRefPubMedPubMedCentral
84.
Verzijl HT, Padberg GW, Zwarts MJ. The spectrum of Mobius syndrome: an electrophysiological study. Brain. 2005;128:1728–36.CrossRefPubMed
85.
Silberstein SDLR, Dalessio DJ. Wolff’s Headache and other head pain. In: Bousser MGGJ, Kittner SJ, Silberstein SD, editors. Headache associated with vascular disorders. Oxford: Oxford University Press; 2001.
86.
Spalice A, Del Balzo F, Papetti L, Zicari AM, Properzi E, Occasi F, et al. Stroke and migraine is there a possible comorbidity? Ital J Pediatr. 2016;42:41.CrossRefPubMedPubMedCentral
87.
Wang YC, Lin CW, Ho YT, Huang YP, Pan SL. Increased risk of ischemic heart disease in young patients with migraine: a population-based, propensity score-matched, longitudinal follow-up study. Int J Cardiol. 2014;172:213–6.CrossRefPubMed
88.
Zhao H, Eising E, de Vries B, Vijfhuizen LS, International headache genetics C, Anttila V, et al. Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia. 2016;36:648–57.CrossRefPubMed
89.
Battaglia A, Doccini V, Bernardini L, Novelli A, Loddo S, Capalbo A, et al. Confirmation of chromosomal microarray as a first-tier clinical diagnostic test for individuals with developmental delay, intellectual disability, autism spectrum disorders and dysmorphic features. Eur J Paediatr Neurol. 2013;17:589–99.CrossRefPubMed
90.
Miller DT, Adam MP, Aradhya S, Biesecker LG, Brothman AR, Carter NP, et al. Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet. 2010;86:749–64.CrossRefPubMedPubMedCentral
91.
de Vries BB, White SM, Knight SJ, Regan R, Homfray T, Young ID, et al. Clinical studies on submicroscopic subtelomeric rearrangements: a checklist. J Med Genet. 2001;38:145–50.CrossRefPubMedPubMedCentral
92.
Italian Association of Human Milk Banks Associazione Italiana Banche del Latte Umano D, Arslanoglu S, Bertino E, Tonetto P, De Nisi G, Ambruzzi AM, et al. Guidelines for the establishment and operation of a donor human milk bank. J Matern Fetal Neonatal Med. 2010;23(Suppl 2):1–20.
93.
Vieira AA, Soares FV, Pimenta HP, Abranches AD, Moreira ME. Analysis of the influence of pasteurization, freezing/thawing, and offer processes on human milk's macronutrient concentrations. Early Hum Dev. 2011;87:577–80.CrossRefPubMed
94.
Ewaschuk JB, Unger S, O'Connor DL, Stone D, Harvey S, Clandinin MT, et al. Effect of pasteurization on selected immune components of donated human breast milk. J Perinatol. 2011;31:593–8.CrossRefPubMed
95.
Peila C, Coscia A, Bertino E, Cavaletto M, Spertino S, Icardi S, Tortone C, Visser GH, Gazzolo D. Effect of Holder pasteurization on the protein profile of human milk. Ital J Pediatr. 2016;7:36.
96.
Opinion of the Scientific Panel on Biological Hazards on the request from the Commission related to the microbiological risks in infant formulae and follow-on formulae. EFSA J. 2004;113:1–35.
97.
Hunter CJ, Bean JF. Cronobacter: an emerging opportunistic pathogen associated with neonatal meningitis, sepsis and necrotizing enterocolitis. J Perinatol. 2013;33:581–5.CrossRefPubMed
98.
Silano M, Paganin P, Davanzo R. Time for the 70 °C water precautionary option in the home dilution of powdered infant formula. Ital J Pediatr. 2016;42:17.CrossRefPubMedPubMedCentral
99.
Kent RM, Fitzgerald GF, Hill C, Stanton C, Ross RP. Novel approaches to improve the intrinsic microbiological safety of powdered infant milk formula. Nutrients. 2015;7:1217–44.CrossRefPubMedPubMedCentral
100.
Seddon PC, Khan Y. Respiratory problems in children with neurological impairment. Arch Dis Childhood. 2003;88:75–8.CrossRef
101.
Schechter MS. Airway clearance applications in infants and children. Respir Care. 2007;52:1382–90.
102.
Takahashi K. Treatment of respiratory disturbance in children with severe physical disabilities to improve their quality of life. No To Hattatsu. 2003;35:215–21.PubMed
103.
Garuti G, Verucchi E, Fanelli I, Giovannini M, Winck JC, Lusuardi M. Management of bronchial secretions with free aspire in children with cerebral palsy: impact on clinical outcomes and healthcare resources. Ital J Pediatr. 2016;42:7.CrossRefPubMedPubMedCentral
104.
Montella S, Corcione A, Santamaria F. Recurrent pneumonia in children: a reasoned diagnostic approach and a single centre experience. Int J Mol Sci. 2017;18.
105.
Montella S, Maglione M, Bruzzese D, Mollica C, Pignata C, Aloj G, et al. Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease. Respirology. 2012;17:87–91.CrossRefPubMed
106.
Patria F, Longhi B, Tagliabue C, Tenconi R, Ballista P, Ricciardi G, et al. Clinical profile of recurrent community-acquired pneumonia in children. BMC Pulm Med. 2013;13:60.CrossRefPubMedPubMedCentral
Metadata
Title
Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology
Authors
Carlo Caffarelli
Francesca Santamaria
Dora Di Mauro
Carla Mastrorilli
Silvia Montella
Sergio Bernasconi
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2017
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-017-0401-9

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