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Italian Journal of Pediatrics

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Open Access 01-12-2016 | Case report

Neonatal lupus erythematosus: a cutaneous cases based update

Authors: Francesco Savino, Serena Viola, Valentina Tarasco, Emanuela Locatelli, Alberto Ricagni, Paola Coppo

Published in: Italian Journal of Pediatrics | Issue 1/2016

Abstract

Background

Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.

Case presentation

Here we report four cases of cutaneous NLE which were referred to our department in the last 10 years and update literature. The newborns presented with different skin, clinical and laboratory features. This underlines the phenotypic variability of NLE. We investigated the passage of maternal antinuclear antibodies (ANA) and extractable nuclear antigen antibodies (ENA) - particularly anti-Ro/SSA, anti-La/SSB and anti-U1 ribonucleoprotein RNP - through the placenta. Despite the positive family background, cutaneous NLE and serological data improved in infants within 4 months without treatment.

Conclusion

The evolution of cutaneous NLE may be the spontaneous regression of lesions within six months without progression to Systemic Lupus Erytehmatosus.

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Title: Neonatal lupus erythematosus: a cutaneous cases based update
Authors: Francesco Savino
Serena Viola
Valentina Tarasco
Emanuela Locatelli
Alberto Ricagni
Paola Coppo
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-015-0208-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neonatal lupus erythematosus: a cutaneous cases based update

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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