Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2017

Open Access 01-12-2017 | Research

Clinical and epidemiological profiles including meteorological factors of low respiratory tract infection due to human rhinovirus in hospitalized children

Authors: Yongdong Yan, Li Huang, Meijuan Wang, Yuqing Wang, Wei Ji, Canhong Zhu, Zhengrong Chen

Published in: Italian Journal of Pediatrics | Issue 1/2017

Login to get access

Abstract

Background

Lower respiratory tract infection (LRTI) is a major cause of morbidity and mortality in children. Human rhinovirus (HRV) is confirmed to be associated with pediatric lower respiratory tract infection. Seasonal and meteorological factors may play a key role in the epidemiology of HRV. The purposes of this study were to investigate the frequency, seasonal distribution, and clinical characteristics of hospitalized children with LRTI caused by HRVs. In addition, associations between incidence of HRVs and meteorological factors in a subtropical region of China were discussed.

Methods

Hospitalized children <14 years old admitted to the Respiratory Department of the Children’s Hospital, which is affiliated to Soochow University, between January 1, 2013 and December 31, 2015, were enrolled in this study. Multi-pathogens were detected in nasopharyngeal aspirate samples. Meanwhile, meteorological factors were recorded.

Results

The average incidence of HRVs infection was 11.4% (707/6194) and 240 cases of which were co-infection cases with other pathogens. Children with co-infection presented more frequent fever and tachypnea compared to children infected with HRVs only (both P < 0.05). Among 707 HRV positive children, the mean age was 23.2 months (range 1 to 140 months). Among all respiratory infections, the highest incidence of HRVs cases occurred in children age 13–36 months old (15.1%, 203/1341). Of all 228 HRV cases in 2014, 85 cases (37.3%) were HRV-C positive. HRVs and HRV-C infection occurred throughout the year during the study period, although a higher incidence was observed in summer and autumn seasons. HRVs or HRV-C incidence in hospitalized children with LRTI was associated with the monthly mean temperature (both P < 0.05).

Conclusion

HRV was one of the most common viral pathogen detected in hospitalized children with LRTI at the Children’s Hospital of Suzhou, China, and had its own seasonal distribution including HRV-C, which was partly caused by temperature.
Literature
1.
Williams BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis. 2002;2:25–32.CrossRefPubMed
2.
O'Callaghan-Gordo C, Bassat Q, Díez-Padrisa N, Morais L, Machevo S, Nhampossa T, et al. Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study. PLoS One. 2013;8:e69370.CrossRefPubMedPubMedCentral
3.
Soto-Quiros M, Avila L, Platts-Mills TA, Hunt JF, Erdman DD, Carper H, et al. High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol. 2012;129:1499–505.CrossRefPubMedPubMedCentral
4.
Midulla F, Pierangeli A, Cangiano G, Bonci E, Salvadei S, Scagnolari C, et al. Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up. Eur Respir J. 2012;39:396–402.CrossRefPubMed
5.
Papadopoulos NG, Moustaki M, Tsolia M, Bossios A, Astra E, Prezerakou A, et al. Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med. 2002;165:1285–89.CrossRefPubMed
6.
Kieninger E, Fuchs O, Latzin P, Frey U, Regamey N. Rhinovirus infections in infancy and early childhood. Eur Respir J. 2013;41:443–52.CrossRefPubMed
7.
Guerrier G, Goyet S, Chheng ET, Rammaert B, Borand L, Te V, et al. Acute viral lower respiratory tract infections in Cambodian children: clinical and epidemiologic characteristics. Pediatr Infect Dis J. 2013;32:e8–13.CrossRefPubMed
8.
Cox DW, Bizzintino J, Ferrari G, Khoo SK, Zhang G, Whelan S, et al. Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions. Am J Respir Crit Care Med. 2013;188:1358–64.CrossRefPubMed
9.
Fry AM, Lu X, Olsen SJ, Chittaganpitch M, Sawatwong P, Chantra S, et al. Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS One. 2011;6:e17780.CrossRefPubMedPubMedCentral
10.
Miller EK, Lu X, Erdman DD, Poehling KA, Zhu Y, Griffin MR, et al. Rhinovirus-associated hospitalizations in young children. J Infect Dis. 2007;195:773–81.CrossRefPubMed
11.
Vesa S, Kleemola M, Blomqvist S, Takala A, Kilpi T, Hovi T. Epidemiology of documented viral respiratory infections and acute otitis media in a cohort of children followed from two to twenty-four months of age. Pediatr Infect Dis J. 2001;20:574–81.CrossRefPubMed
12.
Bicer S, Giray T, Çöl D, Erdağ GÇ, Vitrinel A, Gürol Y, et al. Virological and clinical characterizations of respiratory infections in hospitalized children. Ital J Pediatr. 2013;39:22.CrossRefPubMedPubMedCentral
13.
du Prel JB, Puppe W, Gröndahl B, Knuf M, Weigl JA, Schaaff F, et al. Are meteorological parameters associated with acute respiratory tract infections? Clin Infect Dis. 2009;49:861–68.CrossRefPubMed
14.
Chen ZR, Ji W, Wang YQ, Yan YD, Shao XJ, Zhang XL, et al. Etiology of acute bronchiolitis and the relationship with meteorological conditions in hospitalized infants in China. J Formos Med Assoc. 2014;113:463–9.CrossRefPubMed
15.
Wang Y, Chen Z, Yan YD, Guo H, Chu C, Liu J, et al. Seasonal distribution and epidemiological characteristics of human metapneumovirus infections in pediatric inpatients in Southeast China. Arch Virol. 2013;158:417–24.CrossRefPubMed
16.
Chen Z, Ji W, Wang Y, Yan Y, Zhu H, Shao X, et al. Epidemiology and associations with climatic conditions of mycoplasma pneumoniae and chlamydophila pneumoniae infections among Chinese children hospitalized with acute respiratory infections. Ital J Pediatr. 2013;39:34.CrossRefPubMedPubMedCentral
17.
Granados A, Luinstra K, Chong S, Goodall E, Banh L, Mubareka S, et al. Use of an improved quantitative polymerase chain reaction assay to determine differences in human rhinovirus viral loads in different populations. Diagn Microbiol Infect Dis. 2012;74:384–7.CrossRefPubMed
18.
Jin Y, Yuan XH, Xie ZP, Gao HC, Song JR, Zhang RF, et al. Prevalence and clinical characterization of a newly identified human rhinovirus C species in children with acute respiratory tract infections. J Clin Microbiol. 2009;47:2895–900.CrossRefPubMedPubMedCentral
19.
Yoshida LM, Suzuki M, Nguyen HA, Le MN, Dinh Vu T, et al. Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections. Eur Respir J. 2013;42:461–9.CrossRefPubMed
20.
Linsuwanon P, Payungporn S, Samransamruajkit R, Posuwan N, Makkoch J, Theanboonlers A, et al. High prevalence of human rhinovirus c infection in Thai children with acute lower respiratory tract disease. J Infect. 2009;59:115–21.CrossRefPubMed
21.
Zeng SZ, Xiao NG, Xie ZP, Xie GC, Zhong LL, Wang J, et al. Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China. J Med Virol. 2014;86:1983–9.CrossRefPubMed
22.
Linder JE, Kraft DC, Mohamed Y, Lu Z, Heil L, Tollefson S, et al. Age, season, and lower respiratory illness over the past three decades. J Allergy Clin Immunol. 2013;131:69–77.CrossRefPubMed
23.
Miller EK, Gebretsadik T, Carroll KN, Dupont WD, Mohamed YA, Morin LL, et al. Viral etiologies of infant bronchiolitis, croup and upper respiratory illness during four consecutive years. Pediatr Infect Dis J. 2013;32:950–5.CrossRefPubMed
24.
García-García ML, Calvo C, Pozo F, Villadangos PA, Pérez-Breña P, Casas I. Spectrum of respiratory viruses in children with community acquired pneumonia. Pediatr Infect Dis J. 2012;8:808–13.CrossRef
25.
26.
Mak RKY, Tse LY, Lam WY, Wong GWK, Chan PKS, Leung TF. Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children. Pediatr Infect Dis J. 2011;30:749–53.CrossRefPubMed
27.
Calışkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013;368:1398–407.CrossRefPubMedPubMedCentral
28.
Piralla A, Rovida F, Campanini G, Rognoni V, Marchi A, Locatelli F, et al. Clinical severity and molecular typing of human rhinovirus C strains during a fall outbreak affecting hospitalized patients. J Clin Virol. 2009;45:311–7.CrossRefPubMed
29.
Lau SKP, Yip CCY, Lin AWC, Lee RA, So L-Y, Lau Y-L, et al. Clinical and molecular epidemiology of human rhinovirus C in children and adults in Hong Kong reveals a possible distinct human rhinovirus C subgroup. J Infect Dis. 2009;200:1096–103.CrossRefPubMed
30.
31.
Karim YG, Ijaz MK, Sattar SA, Johnson-Lussenburg CM. Effect of relative humidity on the airborne survival of rhinovirus-14. Can J Microbiol. 1985;31:1058–61.CrossRefPubMed
32.
Milton DK, Glencross PM, Walters MD. Risk of sick leave associated with outdoor air supply rate, humidification, and occupant complaints. Indoor Air. 2000;10:212–21.CrossRefPubMed
Metadata
Title
Clinical and epidemiological profiles including meteorological factors of low respiratory tract infection due to human rhinovirus in hospitalized children
Authors
Yongdong Yan
Li Huang
Meijuan Wang
Yuqing Wang
Wei Ji
Canhong Zhu
Zhengrong Chen
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2017
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-017-0346-z

Other articles of this Issue 1/2017

Italian Journal of Pediatrics 1/2017 Go to the issue

Research

A comparison of blood stream infections with extended spectrum beta-lactamase-producing and non-producing Klebsiella pneumoniae in pediatric patients

Review

ANCA-associated vasculitis in childhood: recent advances

Review

Congenital myopathies: clinical phenotypes and new diagnostic tools

Research

Immunomodulatory constituents of human breast milk and immunity from bronchiolitis

Research

Age and seasons influence on at-home pulse oximetry results in children evaluated for suspected obstructive sleep apnea

Research

Topical corticosteroid phobia in parents of pediatric patients with atopic dermatitis: a multicentre survey