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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2016

Open Access 01-12-2016 | Research

Sleep-wake cycle on amplitude-integrated EEG and neuroimage outcomes in newborns

Authors: Seonkyeong Rhie, Kyu Young Chae, Heui Seung Jo, Kyu Hyung Lee

Published in: Italian Journal of Pediatrics | Issue 1/2016

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Abstract

Background

The aim of this study was to evaluate the results of sleep-wake cycle monitoring using amplitude-integrated EEG (aEEG) and neuroimaging in newborn infants with a possible perinatal hypoxic insult, investigate the correlation between the findings, and determine the relevance of the findings to reasonably predict neurological outcome.

Methods

aEEG was recorded among newborn infants suspected of perinatal asphyxia between November, 2014 and June, 2015 in one neonatal intensive care unit facility. Brain imaging with serial ultrasonography and MRI when available were performed, and the infants were divided into two groups according to findings and potential neurological outcome: Group I (favorable findings) and Group II (severe findings such as high grade intraventricular hemorrhage, cerebral infarction or white matter injury). Established sleep-wake cycle times after birth was compared between the two groups.

Results

Among 107 newborn infants, 85 subjects were classified as Group I and the remaining 22 subjects as Group II. The total number of aEEG sessions was 207 and recording time was 2,796 h with a mean of 14.43 ± 13.40 h per study. Estimated times of cyclicity were earlier in Group I (113.34 h, 95 % CI 82.31–144.37) as compared to Group II (504.39 h, 95 % CI 319.91–688.88; p < 0.001).

Conclusions

Delayed cyclicity on aEEG has a strong correlation with unfavorable brain neuroimages in newborns with possible perinatal asphyxia. If sleep-wake cycles do not appear during initial period after birth, follow-up brain imaging studies are recommended.

Trial registration

Retrospectively registered
Registration number: BD 2015–148
Name of registry: amplitude integrated EEG in neonate
Date of registration: September 9, 2015
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Metadata
Title
Sleep-wake cycle on amplitude-integrated EEG and neuroimage outcomes in newborns
Authors
Seonkyeong Rhie
Kyu Young Chae
Heui Seung Jo
Kyu Hyung Lee
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-016-0294-z

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