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Published in: Italian Journal of Pediatrics 1/2016

Open Access 01-12-2016 | Review

Monitoring of newborns at high risk for brain injury

Authors: Francesco Pisani, Carlotta Spagnoli

Published in: Italian Journal of Pediatrics | Issue 1/2016

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Abstract

Due to the increasing number of surviving preterm newborns and to the recognition of therapeutic hypothermia as the current gold standard in newborns with hypoxic-ischaemic encephalopathy, there has been a growing interest in the implementation of brain monitoring tools in newborns at high risk for neurological disorders.
Among the most frequent neurological conditions and presentations in the neonatal period, neonatal seizures and neonatal status epilepticus, paroxysmal non-epileptic motor phenomena, hypoxic-ischaemic encephalopathy, white matter injury of prematurity and stroke require specific approaches to diagnosis. In this review we will describe the characteristics, aims, indications and limitations of routinely available diagnostic techniques such as conventional and amplitude-integrated EEG, evoked potentials, cranial ultrasound and brain MRI. We will conclude by briefly outlining potential future perspectives from research studies.
Literature
1.
go back to reference Johnson S, Evans TA, Draper ES, Field DJ, Manktelow BN, Marlow N, Matthews R, Petrou S, Seaton SE, Smith LK, Boyle EM. Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study. Arch Dis Child Fetal Neonatal Ed. 2015;100(4):F301–8. Johnson S, Evans TA, Draper ES, Field DJ, Manktelow BN, Marlow N, Matthews R, Petrou S, Seaton SE, Smith LK, Boyle EM. Neurodevelopmental outcomes following late and moderate prematurity: a population-based cohort study. Arch Dis Child Fetal Neonatal Ed. 2015;100(4):F301–8.
2.
go back to reference Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;1, CD003311.PubMed Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;1, CD003311.PubMed
3.
go back to reference Cilio MR. EEG and the newborn. J Pediatric Neurology. 2009;7:25. Cilio MR. EEG and the newborn. J Pediatric Neurology. 2009;7:25.
4.
go back to reference Shelhaas RA, Chang T, Tsuchida T, Scher MS, Riviello JJ, Abend NS, et al. The American clinical neurophysiology society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol. 2011;28:611–7.CrossRef Shelhaas RA, Chang T, Tsuchida T, Scher MS, Riviello JJ, Abend NS, et al. The American clinical neurophysiology society's guideline on continuous electroencephalography monitoring in neonates. J Clin Neurophysiol. 2011;28:611–7.CrossRef
5.
go back to reference McCoy B, Hahn CD. Continuous EEG monitoring in the neonatal intensive care unit. J Clin Neurophysiol. 2013;30:106–14.CrossRefPubMed McCoy B, Hahn CD. Continuous EEG monitoring in the neonatal intensive care unit. J Clin Neurophysiol. 2013;30:106–14.CrossRefPubMed
6.
go back to reference Shah DK, Zempel J, Barton T, Lukas K, Inder TE. Electrographic seizures in preterm infants during the first week of life are associated with cerebral injury. Pediatr Res. 2010;67:102–6.CrossRefPubMed Shah DK, Zempel J, Barton T, Lukas K, Inder TE. Electrographic seizures in preterm infants during the first week of life are associated with cerebral injury. Pediatr Res. 2010;67:102–6.CrossRefPubMed
7.
go back to reference Gupta SN, Kechli AM, Kanamalla US. Intracranial hemorrhage in term newborns: management and outcomes. Pediatr Neurol. 2009;40:1–12.CrossRefPubMed Gupta SN, Kechli AM, Kanamalla US. Intracranial hemorrhage in term newborns: management and outcomes. Pediatr Neurol. 2009;40:1–12.CrossRefPubMed
9.
go back to reference Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology. 1987;37:1837–44.CrossRefPubMed Mizrahi EM, Kellaway P. Characterization and classification of neonatal seizures. Neurology. 1987;37:1837–44.CrossRefPubMed
10.
go back to reference Orivoli S, Facini C, Pisani F. Paroxysmal nonepileptic motor phenomena in newborn. Brain Dev. 2015;37:833–9.CrossRefPubMed Orivoli S, Facini C, Pisani F. Paroxysmal nonepileptic motor phenomena in newborn. Brain Dev. 2015;37:833–9.CrossRefPubMed
11.
go back to reference Hahn JS, Sanger T. Neonatal movement disorders. Neoreviews. 2004;5:e321–6.CrossRef Hahn JS, Sanger T. Neonatal movement disorders. Neoreviews. 2004;5:e321–6.CrossRef
12.
go back to reference Clancy RR, Legido A. The exact ictal and interictal duration of electroencephalographic neonatal seizures. Epilepsia. 1987;28:537–41.CrossRefPubMed Clancy RR, Legido A. The exact ictal and interictal duration of electroencephalographic neonatal seizures. Epilepsia. 1987;28:537–41.CrossRefPubMed
13.
go back to reference Patrizi S, Holmes GL, Orzalesi M, Allemand F. Neonatal seizures: characteristics of EEG ictal activity in preterm and fullterm infants. Brain Dev. 2003;25:427–37.CrossRefPubMed Patrizi S, Holmes GL, Orzalesi M, Allemand F. Neonatal seizures: characteristics of EEG ictal activity in preterm and fullterm infants. Brain Dev. 2003;25:427–37.CrossRefPubMed
14.
go back to reference Okumura A, Hayakawa F, Kato T, Itomi K, Maruyama K, Kubota T, et al. Ictal electroencephalographic findings of neonatal seizures in preterm infants. Brain Dev. 2008;30:261–8.CrossRefPubMed Okumura A, Hayakawa F, Kato T, Itomi K, Maruyama K, Kubota T, et al. Ictal electroencephalographic findings of neonatal seizures in preterm infants. Brain Dev. 2008;30:261–8.CrossRefPubMed
15.
go back to reference Pisani F, Copioli C, Di Gioia C, Turco E, Sisti L. Neonatal seizures: relation of ictal video-electroencephalography (EEG) findings with neurodevelopmental outcome. J Child Neurol. 2008;23:394–8.CrossRefPubMed Pisani F, Copioli C, Di Gioia C, Turco E, Sisti L. Neonatal seizures: relation of ictal video-electroencephalography (EEG) findings with neurodevelopmental outcome. J Child Neurol. 2008;23:394–8.CrossRefPubMed
16.
17.
go back to reference Pavlidis E, Spagnoli C, Pelosi A, Mazzotta S, Pisani F. Neonatal status epilepticus: differences between preterm and term newborns. Eur J Paediatr Neurol. 2015;19:314–9.CrossRefPubMed Pavlidis E, Spagnoli C, Pelosi A, Mazzotta S, Pisani F. Neonatal status epilepticus: differences between preterm and term newborns. Eur J Paediatr Neurol. 2015;19:314–9.CrossRefPubMed
18.
go back to reference Wusthoff CJ. Diagnosing neonatal seizures and status epilepticus. J Clin Neurophysiol. 2013;30(2):115–21.CrossRefPubMed Wusthoff CJ. Diagnosing neonatal seizures and status epilepticus. J Clin Neurophysiol. 2013;30(2):115–21.CrossRefPubMed
19.
go back to reference Pisani F, Cerminara C, Fusco C, Sisti L. Neonatal status epilepticus vs recurrent neonatal seizures: clinical findings and outcome. Neurology. 2007;69:2177–85.CrossRefPubMed Pisani F, Cerminara C, Fusco C, Sisti L. Neonatal status epilepticus vs recurrent neonatal seizures: clinical findings and outcome. Neurology. 2007;69:2177–85.CrossRefPubMed
20.
go back to reference Pisani F, Piccolo B, Cantalupo G, Copioli C, Fusco C, Pelosi A, et al. Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study. Pediatr Res. 2012;72:186–93.CrossRefPubMed Pisani F, Piccolo B, Cantalupo G, Copioli C, Fusco C, Pelosi A, et al. Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study. Pediatr Res. 2012;72:186–93.CrossRefPubMed
21.
go back to reference Scher MS, Alvin J, Gaus L, Minnigh B, Painter MJ. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol. 2003;28:277–80.CrossRefPubMed Scher MS, Alvin J, Gaus L, Minnigh B, Painter MJ. Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use. Pediatr Neurol. 2003;28:277–80.CrossRefPubMed
22.
go back to reference Murray DM, Boylan GB, Ali I, Ryan CA, Murphy BP, Connolly S. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2008;93:F187–91.CrossRefPubMed Murray DM, Boylan GB, Ali I, Ryan CA, Murphy BP, Connolly S. Defining the gap between electrographic seizure burden, clinical expression and staff recognition of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2008;93:F187–91.CrossRefPubMed
23.
go back to reference Boylan G, Burgoyne L, Moore C, O'Flaherty B, Rennie J. An international survey of EEG use in the neonatal intensive care unit. Acta Paediatr. 2010;99:1150–5.CrossRefPubMed Boylan G, Burgoyne L, Moore C, O'Flaherty B, Rennie J. An international survey of EEG use in the neonatal intensive care unit. Acta Paediatr. 2010;99:1150–5.CrossRefPubMed
24.
go back to reference Lamblin MD, Walls Esquivel E, André M. The electroencephalogram of the full-term newborn: review of normal features and hypoxic-ischemic encephalopathy patterns. Neurophysiol Clin. 2013;43(5–6):267–87.CrossRefPubMed Lamblin MD, Walls Esquivel E, André M. The electroencephalogram of the full-term newborn: review of normal features and hypoxic-ischemic encephalopathy patterns. Neurophysiol Clin. 2013;43(5–6):267–87.CrossRefPubMed
26.
go back to reference Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, et al. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121:1146–54.CrossRefPubMed Shah DK, Mackay MT, Lavery S, Watson S, Harvey AS, Zempel J, et al. Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants. Pediatrics. 2008;121:1146–54.CrossRefPubMed
27.
go back to reference Zimbric MR, Sharpe CM, Albright KC, Nespeca MP. Three-channel electroencephalogram montage in neonatal seizure detection and quantification. Pediatr Neurol. 2011;44:31–4.CrossRefPubMed Zimbric MR, Sharpe CM, Albright KC, Nespeca MP. Three-channel electroencephalogram montage in neonatal seizure detection and quantification. Pediatr Neurol. 2011;44:31–4.CrossRefPubMed
28.
go back to reference Shah DK, Boylan GB, Rennie JM. Monitoring of seizures in the newborn. Arch Dis Child Fetal Neonatal Ed. 2012;97:F65–9.CrossRefPubMed Shah DK, Boylan GB, Rennie JM. Monitoring of seizures in the newborn. Arch Dis Child Fetal Neonatal Ed. 2012;97:F65–9.CrossRefPubMed
29.
go back to reference Watanabe K, Hayakawa F, Okumura A. Neonatal EEG: a powerful tool in the assessment of brain damage in preterm infants. Brain Dev. 1999;21:361–72.CrossRefPubMed Watanabe K, Hayakawa F, Okumura A. Neonatal EEG: a powerful tool in the assessment of brain damage in preterm infants. Brain Dev. 1999;21:361–72.CrossRefPubMed
30.
go back to reference Ngueyn The Tich S, d’Allest AM, Villepin AT, de Belliscize J, Walls-Esquivel E, Salefranque F, et al. Pathological features of neonatal EEG in preterm babies born before 30 weeks of gestationnal age. Neurophysiol Clin. 2007;37:325–70.CrossRef Ngueyn The Tich S, d’Allest AM, Villepin AT, de Belliscize J, Walls-Esquivel E, Salefranque F, et al. Pathological features of neonatal EEG in preterm babies born before 30 weeks of gestationnal age. Neurophysiol Clin. 2007;37:325–70.CrossRef
31.
go back to reference Okumura A, Hayakawa F, Kato T, Kuno K, Watanabe K. Developmental outcome and types of chronic-stage EEG abnormalities in preterm infants. Dev Med Child Neurol. 2002;44:729–34.CrossRefPubMed Okumura A, Hayakawa F, Kato T, Kuno K, Watanabe K. Developmental outcome and types of chronic-stage EEG abnormalities in preterm infants. Dev Med Child Neurol. 2002;44:729–34.CrossRefPubMed
32.
go back to reference Tsuji T, Okumura A, Kidokoro H, Hayakawa F, Kubota T, Maruyama K, et al. Differences between periventricular hemorrhagic infarction and periventricular leukomalacia. Brain Dev. 2014;36:555–62. Tsuji T, Okumura A, Kidokoro H, Hayakawa F, Kubota T, Maruyama K, et al. Differences between periventricular hemorrhagic infarction and periventricular leukomalacia. Brain Dev. 2014;36:555–62.
33.
go back to reference Castro Conde JR, Martínez ED, Campo CG, Pérez AM, McLean ML. Positive temporal sharp waves in preterm infants with and without brain ultrasound lesions. Clin Neurophysiol. 2004;115:2479–88.CrossRefPubMed Castro Conde JR, Martínez ED, Campo CG, Pérez AM, McLean ML. Positive temporal sharp waves in preterm infants with and without brain ultrasound lesions. Clin Neurophysiol. 2004;115:2479–88.CrossRefPubMed
34.
go back to reference Kidokoro H, Okumura A, Hayakawa F, Kato T, Maruyama K, Kubota T, Suzuki M, Natsume J, Watanabe K, Kojima S. Chronologic changes in neonatal EEG findings in periventricular leukomalacia. Pediatrics. 2009;124(3):e468–75. Kidokoro H, Okumura A, Hayakawa F, Kato T, Maruyama K, Kubota T, Suzuki M, Natsume J, Watanabe K, Kojima S. Chronologic changes in neonatal EEG findings in periventricular leukomalacia. Pediatrics. 2009;124(3):e468–75.
35.
go back to reference Maruyama K, Okumura A, Hayakawa F, Kato T, Kuno K, Watanabe K. Prognostic value of EEG depression in preterm infants for later development of cerebral palsy. Neuropediatrics. 2002;33:133–7.CrossRefPubMed Maruyama K, Okumura A, Hayakawa F, Kato T, Kuno K, Watanabe K. Prognostic value of EEG depression in preterm infants for later development of cerebral palsy. Neuropediatrics. 2002;33:133–7.CrossRefPubMed
36.
go back to reference Lamblin MD, André M. Electroencephalogram of the full-term newborn. Normal features and hypoxic-ischemic encephalopathy. Neurophysiol Clin. 2011;41:1–18.CrossRefPubMed Lamblin MD, André M. Electroencephalogram of the full-term newborn. Normal features and hypoxic-ischemic encephalopathy. Neurophysiol Clin. 2011;41:1–18.CrossRefPubMed
37.
go back to reference Murray DM, Boylan GB, Ryan CA, Connolly S. Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years. Pediatrics. 2009;124:e459–67.CrossRefPubMed Murray DM, Boylan GB, Ryan CA, Connolly S. Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years. Pediatrics. 2009;124:e459–67.CrossRefPubMed
38.
go back to reference Tsuchida TN, Wusthoff CJ, Shellhaas RA, Abend NS, Hahn CD, Sullivan JE, et al. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee. J Clin Neurophysiol. 2013;30:161–73.CrossRefPubMed Tsuchida TN, Wusthoff CJ, Shellhaas RA, Abend NS, Hahn CD, Sullivan JE, et al. American clinical neurophysiology society standardized EEG terminology and categorization for the description of continuous EEG monitoring in neonates: report of the American Clinical Neurophysiology Society critical care monitoring committee. J Clin Neurophysiol. 2013;30:161–73.CrossRefPubMed
39.
go back to reference Tsuchida TN. EEG background patterns and prognostication of neonatal encephalopathy in the era of hypothermia. J Clin Neurophysiol. 2013;30(2):122–5.CrossRefPubMed Tsuchida TN. EEG background patterns and prognostication of neonatal encephalopathy in the era of hypothermia. J Clin Neurophysiol. 2013;30(2):122–5.CrossRefPubMed
40.
go back to reference Committee on Fetus and Newborn, Papile LA, Baley JE, Benitz W, Cummings J, Carlo WA, et al. Hypothermia and neonatal encephalopathy. Pediatrics. 2014;133:1146–50.CrossRef Committee on Fetus and Newborn, Papile LA, Baley JE, Benitz W, Cummings J, Carlo WA, et al. Hypothermia and neonatal encephalopathy. Pediatrics. 2014;133:1146–50.CrossRef
41.
go back to reference Thoresen M, Hellström-Westas L, Liu X, de Vries LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics. 2010;126:e131–9.CrossRefPubMed Thoresen M, Hellström-Westas L, Liu X, de Vries LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics. 2010;126:e131–9.CrossRefPubMed
42.
go back to reference Chang T, Tsuchida TN. Conventional (continuous) EEG monitoring in the NICU. Curr Pediatr Rev. 2014;10:2–10.CrossRefPubMed Chang T, Tsuchida TN. Conventional (continuous) EEG monitoring in the NICU. Curr Pediatr Rev. 2014;10:2–10.CrossRefPubMed
43.
go back to reference Low E, Mathieson SR, Stevenson NJ, Livingstone V, Ryan CA, Bogue CO, et al. Early postnatal EEG features of perinatal arterial ischaemic stroke with seizures. PLoS One. 2014;9, e100973.CrossRefPubMedPubMedCentral Low E, Mathieson SR, Stevenson NJ, Livingstone V, Ryan CA, Bogue CO, et al. Early postnatal EEG features of perinatal arterial ischaemic stroke with seizures. PLoS One. 2014;9, e100973.CrossRefPubMedPubMedCentral
44.
go back to reference Holmes GL, Moshé SL, Royden Jones Jr H, editors. Clinical neurophysiology of infancy, childhood, and adolescence. Philadelphia: Butterworth Heinemann Elsevier; 2006. Holmes GL, Moshé SL, Royden Jones Jr H, editors. Clinical neurophysiology of infancy, childhood, and adolescence. Philadelphia: Butterworth Heinemann Elsevier; 2006.
45.
go back to reference Naim MY, Gaynor JW, Chen J, Nicolson SC, Fuller S, Spray TL, Dlugos DJ, Clancy RR, Costa LV, Licht DJ, Xiao R, Meldrum H, Abend NS. Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2015;150(1):169–78. Naim MY, Gaynor JW, Chen J, Nicolson SC, Fuller S, Spray TL, Dlugos DJ, Clancy RR, Costa LV, Licht DJ, Xiao R, Meldrum H, Abend NS. Subclinical seizures identified by postoperative electroencephalographic monitoring are common after neonatal cardiac surgery. J Thorac Cardiovasc Surg. 2015;150(1):169–78.
46.
go back to reference Laroia N, Guillet R, Burchfiel J, McBride MC. EEG background as predictor of electrographic seizures in high-risk neonates. Epilepsia. 1998;39:545–51.CrossRefPubMed Laroia N, Guillet R, Burchfiel J, McBride MC. EEG background as predictor of electrographic seizures in high-risk neonates. Epilepsia. 1998;39:545–51.CrossRefPubMed
47.
go back to reference Nash KB, Bonifacio SL, Glass HC, Sullivan JE, Barkovich AJ, Ferriero DM, et al. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy. Neurology. 2011;76:556–62.CrossRefPubMedPubMedCentral Nash KB, Bonifacio SL, Glass HC, Sullivan JE, Barkovich AJ, Ferriero DM, et al. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy. Neurology. 2011;76:556–62.CrossRefPubMedPubMedCentral
48.
go back to reference Pisani F, Barilli AL, Sisti L, Bevilacqua G, Seri S. Preterm infants with video-EEG confirmed seizures: outcome at 30 months of age. Brain Dev. 2008;30:20–30.CrossRefPubMed Pisani F, Barilli AL, Sisti L, Bevilacqua G, Seri S. Preterm infants with video-EEG confirmed seizures: outcome at 30 months of age. Brain Dev. 2008;30:20–30.CrossRefPubMed
49.
go back to reference Taylor MJ, Murphy WJ, Whyte HE. Prognostic reliability of somatosensory and visual evoked potentials of asphyxiated term infants. Dev Med Child Neurol. 1992;34:507–15.CrossRefPubMed Taylor MJ, Murphy WJ, Whyte HE. Prognostic reliability of somatosensory and visual evoked potentials of asphyxiated term infants. Dev Med Child Neurol. 1992;34:507–15.CrossRefPubMed
50.
go back to reference Scalais E, François-Adant A, Nuttin C, Bachy A, Guérit JM. Multimodality evoked potentials as a prognostic tool in term asphyxiated newborns. Electroencephalogr Clin Neurophysiol. 1998;108:199–207.CrossRefPubMed Scalais E, François-Adant A, Nuttin C, Bachy A, Guérit JM. Multimodality evoked potentials as a prognostic tool in term asphyxiated newborns. Electroencephalogr Clin Neurophysiol. 1998;108:199–207.CrossRefPubMed
51.
go back to reference Suppiej A, Cappellari A, Franzoi M, Traverso A, Ermani M, Zanardo V. Bilateral loss of cortical somatosensory evoked potential at birth predicts cerebral palsy in term and near-term newborns. Early Hum Dev. 2010;86:93–8.CrossRefPubMed Suppiej A, Cappellari A, Franzoi M, Traverso A, Ermani M, Zanardo V. Bilateral loss of cortical somatosensory evoked potential at birth predicts cerebral palsy in term and near-term newborns. Early Hum Dev. 2010;86:93–8.CrossRefPubMed
52.
go back to reference Garfinkle J, Sant'Anna GM, Rosenblatt B, Majnemer A, Wintermark P, Shevell MI. Somatosensory evoked potentials in neonates with hypoxic-ischemic encephalopathy treated with hypothermia. Eur J Paediatr Neurol. 2015;19:423–8.CrossRefPubMed Garfinkle J, Sant'Anna GM, Rosenblatt B, Majnemer A, Wintermark P, Shevell MI. Somatosensory evoked potentials in neonates with hypoxic-ischemic encephalopathy treated with hypothermia. Eur J Paediatr Neurol. 2015;19:423–8.CrossRefPubMed
53.
go back to reference Shepherd AJ, Saunders KJ, McCulloch DL, Dutton GN. Prognostic value of flash visual evoked potentials in preterm infants. Dev Med Child Neurol. 1999;41:9–15.CrossRefPubMed Shepherd AJ, Saunders KJ, McCulloch DL, Dutton GN. Prognostic value of flash visual evoked potentials in preterm infants. Dev Med Child Neurol. 1999;41:9–15.CrossRefPubMed
54.
go back to reference Hyde ML, Matsumoto N, Alberti PW. The normative basis for click and frequency-specific BERA in high-risk infants. Acta Otolaryngol. 1987;103:602–11.PubMed Hyde ML, Matsumoto N, Alberti PW. The normative basis for click and frequency-specific BERA in high-risk infants. Acta Otolaryngol. 1987;103:602–11.PubMed
55.
go back to reference Stockard JE, Stockard JJ, Kleinberg F, Westmoreland BF. Prognostic value of brainstem auditory evoked potentials in neonates. Arch Neurol. 1983;40:360–5.CrossRefPubMed Stockard JE, Stockard JJ, Kleinberg F, Westmoreland BF. Prognostic value of brainstem auditory evoked potentials in neonates. Arch Neurol. 1983;40:360–5.CrossRefPubMed
56.
go back to reference van Wezel-Meijler G, Steggerda SJ, Leijser LM. Cranial ultrasonography in neonates: role and limitations. Semin Perinatol. 2010;34:28–38.CrossRefPubMed van Wezel-Meijler G, Steggerda SJ, Leijser LM. Cranial ultrasonography in neonates: role and limitations. Semin Perinatol. 2010;34:28–38.CrossRefPubMed
57.
go back to reference de Vries LS, Benders MJ, Groenendaal F. Imaging the premature brain: ultrasound or MRI? Neuroradiology. 2013;55:13–22.CrossRefPubMed de Vries LS, Benders MJ, Groenendaal F. Imaging the premature brain: ultrasound or MRI? Neuroradiology. 2013;55:13–22.CrossRefPubMed
58.
go back to reference de Vries LS, van Haastert IL, Rademaker KJ, Koopman C, Groenendaal F. Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. J Pediatr 2004;144:815-20. de Vries LS, van Haastert IL, Rademaker KJ, Koopman C, Groenendaal F. Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. J Pediatr 2004;144:815-20.
59.
go back to reference Leijser LM, de Bruine FT, Steggerda SJ, van der Grond J, Walther FJ, van Wezel-Meijler G. Brain imaging findings in very preterm infants throughout the neonatal period: part I. Incidences and evolution of lesions, comparison between ultrasound and MRI. Early Hum Dev. 2009;85:101–9.CrossRefPubMed Leijser LM, de Bruine FT, Steggerda SJ, van der Grond J, Walther FJ, van Wezel-Meijler G. Brain imaging findings in very preterm infants throughout the neonatal period: part I. Incidences and evolution of lesions, comparison between ultrasound and MRI. Early Hum Dev. 2009;85:101–9.CrossRefPubMed
60.
go back to reference Groenendaal F, Termote JUM, Heide-Jalving M, van Haastert IC, de Vries LS. Complications affecting preterm neonates from 1991 to 2006: what have we gained? Acta Paediatr. 2010;99:354–8.CrossRefPubMed Groenendaal F, Termote JUM, Heide-Jalving M, van Haastert IC, de Vries LS. Complications affecting preterm neonates from 1991 to 2006: what have we gained? Acta Paediatr. 2010;99:354–8.CrossRefPubMed
61.
go back to reference Sarkar S, Shankaran S, Laptook AR, Sood BG, Do B, Stoll BJ, Van Meurs KP, Bell EF, Das A, Barks J; Generic Database Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Screening cranial imaging at multiple time points improves cystic periventricular leukomalacia detection. Am J Perinatol. 2015;32(10):973–9. Sarkar S, Shankaran S, Laptook AR, Sood BG, Do B, Stoll BJ, Van Meurs KP, Bell EF, Das A, Barks J; Generic Database Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Screening cranial imaging at multiple time points improves cystic periventricular leukomalacia detection. Am J Perinatol. 2015;32(10):973–9.
62.
go back to reference Daneman A, Epelman M, Blaser S, Jarrin JR. Imaging of the brain in full-term neonates: does sonography still play a role? Pediatr Radiol. 2006;36:636–46.CrossRefPubMed Daneman A, Epelman M, Blaser S, Jarrin JR. Imaging of the brain in full-term neonates: does sonography still play a role? Pediatr Radiol. 2006;36:636–46.CrossRefPubMed
63.
go back to reference Weeke LC, Groenendaal F, Toet MC, Benders MJ, Nievelstein RA, van Rooij LG, de Vries LS. The aetiology of neonatal seizures and the diagnostic contribution of neonatal cerebral magnetic resonance imaging. Dev Med Child Neurol. 2015;57:248–56. Weeke LC, Groenendaal F, Toet MC, Benders MJ, Nievelstein RA, van Rooij LG, de Vries LS. The aetiology of neonatal seizures and the diagnostic contribution of neonatal cerebral magnetic resonance imaging. Dev Med Child Neurol. 2015;57:248–56.
64.
go back to reference Kwon SH, Vasung L, Ment LR, Huppi PS. The role of neuroimaging in predicting neurodevelopmental outcomes of preterm neonates. Clin Perinatol. 2014;41:257–83.CrossRefPubMed Kwon SH, Vasung L, Ment LR, Huppi PS. The role of neuroimaging in predicting neurodevelopmental outcomes of preterm neonates. Clin Perinatol. 2014;41:257–83.CrossRefPubMed
65.
go back to reference Leijser LM, de Vries LS, Cowan FM. Using cerebral ultrasound effectively in the newborn infant. Early Hum Dev. 2006;82:827–35.CrossRefPubMed Leijser LM, de Vries LS, Cowan FM. Using cerebral ultrasound effectively in the newborn infant. Early Hum Dev. 2006;82:827–35.CrossRefPubMed
66.
go back to reference Brouwer MJ, de Vries LS, Groenendaal F, Koopman C, Pistorius LR, Mulder EJ, Benders MJ. New reference values for the neonatal cerebral ventricles. Radiology. 2012;262(1):224–33. Brouwer MJ, de Vries LS, Groenendaal F, Koopman C, Pistorius LR, Mulder EJ, Benders MJ. New reference values for the neonatal cerebral ventricles. Radiology. 2012;262(1):224–33.
67.
go back to reference Brouwer MJ, de Vries LS, Pistorius L, Rademaker KJ, Groenendaal F, Benders MJ. Ultrasound measurements of the lateral ventricles in neonates: why, how and when? A systematic review. Acta Paediatr. 2010;99(9):1298–306.CrossRefPubMed Brouwer MJ, de Vries LS, Pistorius L, Rademaker KJ, Groenendaal F, Benders MJ. Ultrasound measurements of the lateral ventricles in neonates: why, how and when? A systematic review. Acta Paediatr. 2010;99(9):1298–306.CrossRefPubMed
68.
go back to reference Chau V, Synnes A, Grunau RE, Poskitt KJ, Brant R, Miller SP. Abnormal brain maturation in preterm neonates associated with adverse developmental outcomes. Neurology. 2013;81(24):2082–9.CrossRefPubMedPubMedCentral Chau V, Synnes A, Grunau RE, Poskitt KJ, Brant R, Miller SP. Abnormal brain maturation in preterm neonates associated with adverse developmental outcomes. Neurology. 2013;81(24):2082–9.CrossRefPubMedPubMedCentral
69.
go back to reference Anderson PJ, Cheong JL, Thompson DK. The predictive validity of neonatal MRI for neurodevelopmental outcome in very preterm children. Semin Perinatol. 2015;39(2):147–58.CrossRefPubMed Anderson PJ, Cheong JL, Thompson DK. The predictive validity of neonatal MRI for neurodevelopmental outcome in very preterm children. Semin Perinatol. 2015;39(2):147–58.CrossRefPubMed
70.
go back to reference Holland D, Chang L, Ernst TM, Curran M, Buchthal SD, Alicata D, Skranes J, Johansen H, Hernandez A, Yamakawa R, Kuperman JM, Dale AM. Structural growth trajectories and rates of change in the first 3 months of infant brain development. JAMA Neurol. 2014;71(10):1266–74. Holland D, Chang L, Ernst TM, Curran M, Buchthal SD, Alicata D, Skranes J, Johansen H, Hernandez A, Yamakawa R, Kuperman JM, Dale AM. Structural growth trajectories and rates of change in the first 3 months of infant brain development. JAMA Neurol. 2014;71(10):1266–74.
71.
go back to reference Kidokoro H, Anderson PJ, Doyle LW, Woodward LJ, Neil JJ, Inder TE. Brain injury and altered brain growth in preterm infants: predictors and prognosis. Pediatrics. 2014;134:e444–53.CrossRefPubMed Kidokoro H, Anderson PJ, Doyle LW, Woodward LJ, Neil JJ, Inder TE. Brain injury and altered brain growth in preterm infants: predictors and prognosis. Pediatrics. 2014;134:e444–53.CrossRefPubMed
72.
go back to reference Bednarek N, Mathur A, Inder T, Wilkinson J, Neil J, Shimony J. Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology. 2012;78:1420–7.CrossRefPubMedPubMedCentral Bednarek N, Mathur A, Inder T, Wilkinson J, Neil J, Shimony J. Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. Neurology. 2012;78:1420–7.CrossRefPubMedPubMedCentral
73.
go back to reference de Vries LS, Verboon-Maciolek MA, Cowan FM, Groenendaal F. The role of cranial ultrasound and magnetic resonance imaging in the diagnosis of infections of the central nervous system. Early Hum Dev. 2006;82:819–25.CrossRefPubMed de Vries LS, Verboon-Maciolek MA, Cowan FM, Groenendaal F. The role of cranial ultrasound and magnetic resonance imaging in the diagnosis of infections of the central nervous system. Early Hum Dev. 2006;82:819–25.CrossRefPubMed
74.
go back to reference Lequin MH, Vermeulen JR, van Elburg RM, Barkhof F, Kornelisse RF, Swarte R, Govaert PP. Bacillus cereus meningoencephalitis in preterm infants: neuroimaging characteristics. AJNR Am J Neuroradiol. 2005;26:2137–43. Lequin MH, Vermeulen JR, van Elburg RM, Barkhof F, Kornelisse RF, Swarte R, Govaert PP. Bacillus cereus meningoencephalitis in preterm infants: neuroimaging characteristics. AJNR Am J Neuroradiol. 2005;26:2137–43.
77.
go back to reference Riviello Jr JJ. Digital trend analysis in the pediatric and neonatal intensive care units. J Clin Neurophysiol. 2013;30:143–55.CrossRefPubMed Riviello Jr JJ. Digital trend analysis in the pediatric and neonatal intensive care units. J Clin Neurophysiol. 2013;30:143–55.CrossRefPubMed
78.
go back to reference Abend NS, Dlugos D, Herman S. Neonatal seizure detection using multichannel display of envelope trend. Epilepsia. 2008;49:349.CrossRefPubMed Abend NS, Dlugos D, Herman S. Neonatal seizure detection using multichannel display of envelope trend. Epilepsia. 2008;49:349.CrossRefPubMed
80.
go back to reference Murphy K, Stevenson NJ, Goulding RM, Lloyd RO, Korotchikova I, Livingstone V, Boylan GB. Automated analysis of multi-channel EEG in preterm infants. Clin Neurophysiol. 2015;126:1692–702. Murphy K, Stevenson NJ, Goulding RM, Lloyd RO, Korotchikova I, Livingstone V, Boylan GB. Automated analysis of multi-channel EEG in preterm infants. Clin Neurophysiol. 2015;126:1692–702.
81.
go back to reference Karayiannis NB, Tao G, Frost Jr JD, Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures based on motion segmentation methods. Clin Neurophysiol. 2006;117:1585–94.CrossRefPubMed Karayiannis NB, Tao G, Frost Jr JD, Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures based on motion segmentation methods. Clin Neurophysiol. 2006;117:1585–94.CrossRefPubMed
82.
go back to reference Pisani F, Spagnoli C, Pavlidis E, Facini C, Kouamou Ntonfo GM, Ferrari G, Raheli R. Real-time automated detection of clonic seizures in newborns. Clin Neurophysiol. 2014;125:1533–40. Pisani F, Spagnoli C, Pavlidis E, Facini C, Kouamou Ntonfo GM, Ferrari G, Raheli R. Real-time automated detection of clonic seizures in newborns. Clin Neurophysiol. 2014;125:1533–40.
83.
go back to reference Ntonfo GM, Ferrari G, Raheli R, Pisani F. Low-complexity image processing for real-time detection of neonatal clonic seizures. IEEE Trans Inf Technol Biomed. 2012;16:375–82.CrossRefPubMed Ntonfo GM, Ferrari G, Raheli R, Pisani F. Low-complexity image processing for real-time detection of neonatal clonic seizures. IEEE Trans Inf Technol Biomed. 2012;16:375–82.CrossRefPubMed
84.
go back to reference Mathieson SR, Stevenson NJ, Low E, Marnane WP, Rennie JM, Temko A, Lightbody G, Boylan GB. Validation of an automated seizure detection algorithm for term neonates. Clin Neurophysiol. 2015. doi:10.1016/j.clinph.2015.04.075. Mathieson SR, Stevenson NJ, Low E, Marnane WP, Rennie JM, Temko A, Lightbody G, Boylan GB. Validation of an automated seizure detection algorithm for term neonates. Clin Neurophysiol. 2015. doi:10.​1016/​j.​clinph.​2015.​04.​075.
85.
go back to reference Alinovi D, Cattani L, Ferrari G, Pisani F, Raheli R. Video simulation of apnoea episodes. IEEE International Conference on Multimedia Expo Workshops (ICMEW). 2015. Alinovi D, Cattani L, Ferrari G, Pisani F, Raheli R. Video simulation of apnoea episodes. IEEE International Conference on Multimedia Expo Workshops (ICMEW). 2015.
86.
go back to reference Alinovi D, Cattani L, Ferrari G, Pisani F, Raheli R. Spatio-temporal video processing for respiratory rate estimation, IEEE International symposium on medical measurements and applications (MeMeA). 2015.CrossRef Alinovi D, Cattani L, Ferrari G, Pisani F, Raheli R. Spatio-temporal video processing for respiratory rate estimation, IEEE International symposium on medical measurements and applications (MeMeA). 2015.CrossRef
88.
go back to reference Roche-Labarbe N, Aarabi A, Kongolo G, Gondry-Jouet C, Dümpelmann M, Grebe R, et al. High-resolution electroencephalography and source localization in neonates. Hum Brain Mapp. 2008;29:167–76.CrossRefPubMed Roche-Labarbe N, Aarabi A, Kongolo G, Gondry-Jouet C, Dümpelmann M, Grebe R, et al. High-resolution electroencephalography and source localization in neonates. Hum Brain Mapp. 2008;29:167–76.CrossRefPubMed
89.
go back to reference Rennie JM, Kendall GS. Advanced magnetic resonance techniques provide more accurate prognostic information than conventional imaging. Dev Med Child Neurol. 2015;57:403–4.CrossRefPubMed Rennie JM, Kendall GS. Advanced magnetic resonance techniques provide more accurate prognostic information than conventional imaging. Dev Med Child Neurol. 2015;57:403–4.CrossRefPubMed
Metadata
Title
Monitoring of newborns at high risk for brain injury
Authors
Francesco Pisani
Carlotta Spagnoli
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-016-0261-8

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