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01-08-2013 | Review

Update on differences between childhood-onset and adult-onset systemic lupus erythematosus

Authors: Rina Mina, Hermine I Brunner

Published in: Arthritis Research & Therapy | Issue 4/2013

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences in disease manifestations, medication use, and disease severity between those with childhood-onset SLE as compared with adult-onset SLE. Children have a more fulminant disease onset and course than adults with SLE, resulting in two to three times higher mortality. In future years, we anticipate more insight into the genetics between childhood-onset SLE and adult-onset SLE to help delineate the best therapies for both subsets of patients.

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Title: Update on differences between childhood-onset and adult-onset systemic lupus erythematosus
Authors: Rina Mina
Hermine I Brunner
Publication date: 01-08-2013
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 4/2013
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar4256

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Update on differences between childhood-onset and adult-onset systemic lupus erythematosus

Abstract

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Abstract

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