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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2019

Open Access 01-12-2019 | Endometrial Cancer | Research

Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data

Authors: Yinglian Pan, Li Ping Jia, Yuzhu Liu, Yixu Han, Qingchun Deng

Published in: Journal of Ovarian Research | Issue 1/2019

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Abstract

Uterine corpus endometrial carcinoma (UCEC) is one of the most common cancer in female worldwide. PIK3CA has been proven to be a strong prognostic biomarker in UCEC. Nevertheless, current studies have not investigated what effects PIK3CA had on tumor associated neutrophils (TANss). Kaplan-Meier methods were used to compute the survival time of TCGA UCEC patients. GO and KEGG enrichment analysis unveiled relevant pathways PIK3CA affected using DEGs between PIK3CA high expression group and PIK3CA low expression group in TCGA UCEC, as well as GSEA. immune infiltration status was calculated using TIMER. We found that PIK3CA influenced a number of pathways including immune related pathways. The fraction of TANs was certainly altered by PIK3CA expression in UCEC. Our findings suggest that PIK3CA expression may play an important role in tumor immune microenvironment and could alter fraction of TANs in UCEC.
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Metadata
Title
Alteration of tumor associated neutrophils by PIK3CA expression in endometrial carcinoma from TCGA data
Authors
Yinglian Pan
Li Ping Jia
Yuzhu Liu
Yixu Han
Qingchun Deng
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2019
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-019-0557-6

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