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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2019

Open Access 01-12-2019 | Ovarian Cancer | Research

Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer

Authors: Enrique Pedernera, María J. Gómora, Flavia Morales-Vásquez, Delia Pérez-Montiel, Carmen Mendez

Published in: Journal of Ovarian Research | Issue 1/2019

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Abstract

Background

Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian cancer progression has been largely evaluated. The presence of progesterone receptors has been associated with an increase of a disease-free period and overall survival in patients with ovarian carcinoma. In the present study, primary cultures of ovarian carcinoma obtained from 35 patients diagnosed with epithelial ovarian cancer were evaluated for cell survival after treatment with 10− 8 M of 17β-estradiol, progesterone, testosterone and dihydrotestosterone.

Results

The results were analyzed considering histological subtypes: low grade serous, high grade serous, endometrioid and mucinous carcinoma; clear cell carcinoma was not included due to failure in obtaining successful cultures of this subtype. A significant reduction of cell survival was observed after progesterone treatment in endometrioid ovarian carcinoma. Changes were not observed in low grade serous, high grade serous and mucinous carcinoma. The effect of progesterone was related to the presence of progesterone receptor (PR), a 43% reduction in the cell number was observed in PR (+) endometrioid ovarian carcinoma.

Conclusions

This study supports the importance of progesterone and the presence of progesterone receptor in the reduction of ovarian cancer progression in the endometrioid ovarian carcinoma.
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Metadata
Title
Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer
Authors
Enrique Pedernera
María J. Gómora
Flavia Morales-Vásquez
Delia Pérez-Montiel
Carmen Mendez
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2019
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-019-0486-4

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