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Journal of Ovarian Research

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Open Access 01-12-2018 | Research

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Authors: V. N. A. Ho, T. D. Pham, A. H. Le, T. M. Ho, L. N. Vuong

Published in: Journal of Ovarian Research | Issue 1/2018

Abstract

Background

In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the live birth rate in a large series of PCOS women undergoing human chorionic gonadotropin (hCG)-priming IVM.

Methods

This retrospective study included women with PCOS aged 18–42 years undergoing IVM with hCG priming. We reported live birth rate after the first embryo transfer and cumulative live birth rate from embryos obtained in the IVM cycle. We also performed logistic regression to assess which factors predicted number of oocytes and live birth.

Results

We included 921 women (age 28.9±3.5 years, body mass index 21.8±3.1 kg/m², infertility duration 3.7±2.6 years, 81% primary infertility, 88% first IVF attempt, 94% ovulation induction failure). Live birth rate after the first embryo transfer was 31.7%, with a cumulative live birth rate from the cycle of 33.7%. High anti-Müllerian hormone levels predicted a high number of oocytes and a high oocyte maturation rate while the opposite was the case when luteinizing hormone levels were high.

Conclusions

In women with PCOS, hCG priming IVM was feasible and resulted in acceptable live birth rates.

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Title: Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome
Authors: V. N. A. Ho
T. D. Pham
A. H. Le
T. M. Ho
L. N. Vuong
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2018
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/s13048-018-0445-5

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Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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