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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2018

Open Access 01-12-2018 | Research

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

Authors: Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio, Carlo Leonetti

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2018

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Abstract

Developing drugs that target KRAS, the most frequently mutated oncogene in cancer, has not been successful despite much concerted efforts dedicated towards it in the last thirty years. Considering the key role this driver oncogene plays, the pharmacological drugging of KRAS remains a key challenge for cancer research. In this review, we highlight the emerging experimental strategies for blocking KRAS function and signaling and its direct targeting. We also report on the results in this field of research produced by our group.
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Metadata
Title
Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities
Authors
Manuela Porru
Luca Pompili
Carla Caruso
Annamaria Biroccio
Carlo Leonetti
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2018
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-018-0719-1

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