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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2020

Open Access 01-12-2020 | Myelodysplastic Syndrome | Letter to the Editor

The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing

Authors: Lorena Zubovic, Silvano Piazza, Toma Tebaldi, Luca Cozzuto, Giuliana Palazzo, Viktoryia Sidarovich, Veronica De Sanctis, Roberto Bertorelli, Tim Lammens, Mattias Hofmans, Barbara De Moerloose, Julia Ponomarenko, Martina Pigazzi, Riccardo Masetti, Cristina Mecucci, Giuseppe Basso, Paolo Macchi

Published in: Journal of Hematology & Oncology | Issue 1/2020

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Abstract

Pediatric myelodysplastic syndrome (PMDS) is a very rare and still poorly characterized disorder. In this work, we identified novel potential targets of PMDS by determining genes with aberrant expression, which can be correlated with PMDS pathogenesis. We identified 291 differentially expressed genes (DEGs) in PMDS patients, comprising genes involved in the regulation of apoptosis and the cell cycle, ribosome biogenesis, inflammation and adaptive immunity. Ten selected DEGs were then validated, confirming the sequencing data. These DEGs will potentially represent new molecular biomarkers and therapeutic targets for PMDS.
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Metadata
Title
The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing
Authors
Lorena Zubovic
Silvano Piazza
Toma Tebaldi
Luca Cozzuto
Giuliana Palazzo
Viktoryia Sidarovich
Veronica De Sanctis
Roberto Bertorelli
Tim Lammens
Mattias Hofmans
Barbara De Moerloose
Julia Ponomarenko
Martina Pigazzi
Riccardo Masetti
Cristina Mecucci
Giuseppe Basso
Paolo Macchi
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2020
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-020-00974-3

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