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Open Access 01-12-2020 | Biomarkers | Review

Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

Authors: Yuanliang Yan, Guijie Guo, Jinzhou Huang, Ming Gao, Qian Zhu, Shuangshuang Zeng, Zhicheng Gong, Zhijie Xu

Published in: Journal of Hematology & Oncology | Issue 1/2020

Abstract

Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of oncogenes and therapeutic resistance genes located on extrachromosomal DNA is a frequent event that drives intratumoral genetic heterogeneity and provides a potential evolutionary advantage. This review highlights the current understanding of the extrachromosomal circular DNA present in the tissues and circulation of patients with advanced cancers and provides a detailed discussion of their substantial roles in tumor regulation. Confirming the presence of cancer-related extrachromosomal circular DNA would provide a putative testing strategy for the precision diagnosis and treatment of human malignancies in clinical practice.

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Title: Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
Authors: Yuanliang Yan
Guijie Guo
Jinzhou Huang
Ming Gao
Qian Zhu
Shuangshuang Zeng
Zhicheng Gong
Zhijie Xu
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Biomarkers
Published in: Journal of Hematology & Oncology / Issue 1/2020
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-020-00960-9

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