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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2020

Open Access 01-12-2020 | Review

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

Authors: Wenyu Wang, Youngjin Han, Hyun A Jo, Juwon Lee, Yong Sang Song

Published in: Journal of Hematology & Oncology | Issue 1/2020

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Abstract

Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions.
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Metadata
Title
Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
Authors
Wenyu Wang
Youngjin Han
Hyun A Jo
Juwon Lee
Yong Sang Song
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2020
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-020-00893-3

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