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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2019

Open Access 01-12-2019 | Solid Tumor | Review

Target selection for CAR-T therapy

Authors: Jianshu Wei, Xiao Han, Jian Bo, Weidong Han

Published in: Journal of Hematology & Oncology | Issue 1/2019

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Abstract

Chimeric antigen receptor-modified T (CAR-T) cells have achieved significant success in the treatment of several hematological malignancies. However, the translation of the existing achievements into the treatment of other tumors, especially solid tumors, is not smooth. In addition to the optimization of CAR structures, preparation, and clinical protocols, rational selecting and utilizing the targets was more pivotal. In this review, the criteria for target selection and some new strategies for targets utilization were summarized and discussed. This systematic review will help researchers better understand how the efficacy and safety of CAR-T treatment would be affected by targets and thus more rationally select targets and conduct clinical trials.
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Metadata
Title
Target selection for CAR-T therapy
Authors
Jianshu Wei
Xiao Han
Jian Bo
Weidong Han
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Solid Tumor
Published in
Journal of Hematology & Oncology / Issue 1/2019
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-019-0758-x

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