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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2018

Open Access 01-12-2018 | Review

Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions

Authors: Yiyin Zhang, Chao Yang, He Cheng, Zhiyao Fan, Qiuyi Huang, Yu Lu, Kun Fan, Guopei Luo, Kaizhou Jin, Zhengshi Wang, Chen Liu, Xianjun Yu

Published in: Journal of Hematology & Oncology | Issue 1/2018

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Abstract

A poor prognosis of pancreatic ductal adenocarcinoma (PDAC) associated with chemoresistance has not changed for the past three decades. A multidisciplinary diagnosis followed by surgery and chemo(radiation)therapy is the main treatment approach. However, gemcitabine- and 5-fluorouracil-based therapies did not present satisfying outcomes. Novel regimens targeting pancreatic cancer cells, the tumor microenvironment, and immunosuppression are emerging. Biomarkers concerning the treatment outcome and patient selection are being discovered in preclinical or clinical studies. Combination therapies of classic chemotherapeutic drugs and novel agents or novel therapeutic combinations might bring hope to the dismal prognosis for PDAC patients.
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Metadata
Title
Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions
Authors
Yiyin Zhang
Chao Yang
He Cheng
Zhiyao Fan
Qiuyi Huang
Yu Lu
Kun Fan
Guopei Luo
Kaizhou Jin
Zhengshi Wang
Chen Liu
Xianjun Yu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2018
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-017-0551-7

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