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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2017

Open Access 01-12-2017 | Review

Uncovering the roles of long non-coding RNAs in cancer stem cells

Authors: Xiaoxing Huang, Ruijing Xiao, Shan Pan, Xiangyong Yang, Wen Yuan, Zhenbo Tu, Ming Xu, Yufan Zhu, Qian Yin, Yingjie Wu, Weidong Hu, Liang Shao, Jie Xiong, Qiuping Zhang

Published in: Journal of Hematology & Oncology | Issue 1/2017

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Abstract

Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer stem cells are a group of tumor cells that possess self-renewal and differentiation ability, which is a vital cause of cancer metastasis and recurrence. Long non-coding RNAs refer to a class of RNAs that are longer than 200 nt and have no potential to code proteins, some of which can be specifically expressed in different tissues and different tumors. Long non-coding RNAs have great biological significance in the occurrence and progression of cancers. However, how long non-coding RNAs interact with cancer stem cells and then affect cancer metastasis and recurrence is not yet clear. Therefore, this review aims to summarize recent studies that focus on how long non-coding RNAs impact tumor occurrence and progression by affecting cancer stem cell self-renewal and differentiation in liver cancer, prostate cancer, breast cancer, and glioma.
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Metadata
Title
Uncovering the roles of long non-coding RNAs in cancer stem cells
Authors
Xiaoxing Huang
Ruijing Xiao
Shan Pan
Xiangyong Yang
Wen Yuan
Zhenbo Tu
Ming Xu
Yufan Zhu
Qian Yin
Yingjie Wu
Weidong Hu
Liang Shao
Jie Xiong
Qiuping Zhang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2017
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-017-0428-9

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