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Open Access 01-12-2016 | Review

The role of HGF/c-MET signaling pathway in lymphoma

Authors: Bao Quoc Lam, Lu Dai, Zhiqiang Qin

Published in: Journal of Hematology & Oncology | Issue 1/2016

Abstract

Inappropriate activation of c-mesenchymal-epithelial transition (MET), the receptor tyrosine kinase (RTK) for hepatocyte growth factor (HGF), has been implicated in tumorigenesis and represented a promising therapeutic target for developing anticancer agents. In contrast to other solid tumors, there are limited data describing the functional role of HGF/c-MET signaling pathway in lymphoma. In the current review, we summarize recent findings about the expression, cellular mechanisms/functions, and therapeutic application of HGF/c-MET in different types of lymphoma, especially B cell lymphoma, T and NK cell lymphoma, and Hodgkin lymphoma. We also discuss the existing problems and future directions about studying the HGF/c-MET pathway in lymphoma cells.

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Title: The role of HGF/c-MET signaling pathway in lymphoma
Authors: Bao Quoc Lam
Lu Dai
Zhiqiang Qin
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2016
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-016-0366-y

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