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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2015

Open Access 01-12-2015 | Research

A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40

Authors: Jingtao Chen, Gerard Zurawski, Sandy Zurawski, Zhiqing Wang, Keiko Akagawa, Sangkon Oh, Ueno Hideki, Joseph Fay, Jacques Banchereau, Wenru Song, A Karolina Palucka

Published in: Journal of Hematology & Oncology | Issue 1/2015

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Abstract

Background

Mantle cell lymphoma (MCL) is a distinct clinical pathologic subtype of B cell non-Hodgkin’s lymphoma often associated with poor prognosis. New therapeutic approaches based on boosting anti-tumor immunity are needed. MCL is associated with overexpression of cyclin D1 thus rendering this molecule an interesting target for immunotherapy.

Methods

We show here a novel strategy for the development of recombinant vaccines carrying cyclin D1 cancer antigens that can be targeted to dendritic cells (DCs) via CD40.

Results

Healthy individuals and MCL patients have a broad repertoire of cyclin D1-specific CD4+ and CD8+ T cells. Cyclin D1-specific T cells secrete IFN-γ. DCs loaded with whole tumor cells or with selected peptides can elicit cyclin D1-specific CD8+ T cells that kill MCL tumor cells. We developed a recombinant vaccine based on targeting cyclin D1 antigen to human DCs via an anti-CD40 mAb. Targeting monocyte-derived human DCs in vitro with anti-CD40-cyclin D1 fusion protein expanded a broad repertoire of cyclin D1-specific CD4+ and CD8+ T cells.

Conclusions

This study demonstrated that cyclin D1 represents a good target for immunotherapy and targeting cyclin D1 to DCs provides a new strategy for mantle cell lymphoma vaccine.
Appendix
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Metadata
Title
A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40
Authors
Jingtao Chen
Gerard Zurawski
Sandy Zurawski
Zhiqing Wang
Keiko Akagawa
Sangkon Oh
Ueno Hideki
Joseph Fay
Jacques Banchereau
Wenru Song
A Karolina Palucka
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2015
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-015-0131-7

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