Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Patient Safety in Surgery
Published in: Patient Safety in Surgery 1/2015

Open Access 01-12-2015 | Short report

Preoperative Glucagon-like peptide-1 receptor imaging reduces surgical trauma and pancreatic tissue loss in insulinoma patients: a report of three cases

Authors: Anna Silvia Wenning, Paul Kirchner, Kwadwo Antwi, Melpomeni Fani, Damian Wild, Emanuel Christ, Beat Gloor

Published in: Patient Safety in Surgery | Issue 1/2015

Login to get access

Abstract

Background

Insulinomas are rare tumors, in the majority of cases best treated by surgical resection. Preoperative localization of insulinoma is challenging. The more precise the preoperative localization the less invasive and safer is the resection. The purpose of the study is to check the impact of a new technique to localize insulinoma on the surgical strategy.

Findings

We present exact preoperative localization with Glucagon-like peptide-1 receptor (GLP-1R) imaging. This allows a more precise resection thereby reducing surgical access trauma, loss of healthy pancreatic tissue and increasing safety and quality of the surgical intervention.

Conclusion

With the help of precise preoperative localization of insulinoma with GLP-1R imaging the surgeon is able to minimize the amount of resected healthy pancreatic tissue. We hypothesize that GLP-1R imaging will become a preoperative diagnostic tool to be used for many patients scheduled for open or laparoscopic insulinoma resection.
Literature
1.
Mehrabi A, Fischer L, Hafezi M, Dirlewanger A, Grenacher L, Diener MK, et al. A systematic review of localization, surgical treatment options, and outcome of insulinoma. Pancreas. 2014;43(5):675–86.CrossRefPubMed
2.
Shin LK, Brant-Zawadzki G, Kamaya A, Jeffrey RB. Intraoperative ultrasound of the pancreas. Ultrasound Q. 2009;25(1):39–48.CrossRefPubMed
3.
Christ E, Wild D, Ederer S, Behe M, Nicolas G, Caplin ME, et al. Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study. Lancet Diabetes Endocrinol. 2013;1(2):115–22.CrossRefPubMed
4.
Christ E, Wild D, Forrer F, Brandle M, Sahli R, Clerici T, et al. Glucagon-like peptide-1 receptor imaging for localization of insulinomas. J Clin Endocrinol Metabolism. 2009;94(11):4398–405.CrossRef
5.
Wild D, Macke H, Christ E, Gloor B, Reubi JC. Glucagon-like peptide 1-receptor scans to localize occult insulinomas. N Engl J Med. 2008;359(7):766–8.CrossRefPubMed
Metadata
Title
Preoperative Glucagon-like peptide-1 receptor imaging reduces surgical trauma and pancreatic tissue loss in insulinoma patients: a report of three cases
Authors
Anna Silvia Wenning
Paul Kirchner
Kwadwo Antwi
Melpomeni Fani
Damian Wild
Emanuel Christ
Beat Gloor
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Patient Safety in Surgery / Issue 1/2015
Electronic ISSN: 1754-9493
DOI
https://doi.org/10.1186/s13037-015-0064-7

Other articles of this Issue 1/2015

Patient Safety in Surgery 1/2015 Go to the issue

Research

Proctitis after stapled hemorrhoidopexy is an underestimated complication of a widely used surgical procedure: a retrospective observational cohort study in 129 patients

Short Report

Are surgeons and anesthesiologists lying to each other or gaming the system? A national random sample survey about “truth-telling practices” in the perioperative setting in the United States

Research

Are radiographic indices reliable indicators for quantitative bone mineral density and vitamin D status after femoral neck fractures? A retrospective study in 112 elderly patients

Case report

The horror of wrong-site surgery continues: report of two cases in a regional trauma centre in Nigeria

Editorial

Safety in surgery: the role of shared decision-making

Research

Digital mobile technology facilitates HIPAA-sensitive perioperative messaging, improves physician-patient communication, and streamlines patient care