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Infectious Agents and Cancer
Published in: Infectious Agents and Cancer 1/2016

Open Access 01-12-2016 | Review

Systemic manifestations of hepatitis C infection

Authors: Lydia Tang, Lauren Marcell, Shyam Kottilil

Published in: Infectious Agents and Cancer | Issue 1/2016

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Abstract

Chronic hepatitis C (HCV) is a common infection affecting 185 million people worldwide. The most common manifestation of chronic HCV is progressive liver fibrosis, cirrhosis, liver failure and hepatocellular carcinoma. However, several systemic manifestations of HCV have been recognized and reported in the literature. The purpose of this review is to assimilate published literature based on evidence to categorize these extrahepatic manifestations with the likelihood of a causal association with HCV. Exciting recent developments have resulted in simple all oral interferon-free highly effective therapy for HCV. However, this treatment is also expensive and less accessible to most affected individuals as treatment recommendations are based on stage of liver fibrosis. Expanding the scope of HCV therapy to those with extrahepatic manifestations beyond what is currently recommended will significantly reduce the morbidity and mortality in this aging population.
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Metadata
Title
Systemic manifestations of hepatitis C infection
Authors
Lydia Tang
Lauren Marcell
Shyam Kottilil
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Infectious Agents and Cancer / Issue 1/2016
Electronic ISSN: 1750-9378
DOI
https://doi.org/10.1186/s13027-016-0076-7

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