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Open Access 01-12-2016 | Short Report

Non-typhoidal Salmonella DNA traces in gallbladder cancer

Authors: Prajish Iyer, Savio George Barreto, Bikram Sahoo, Pratik Chandrani, Mukta R. Ramadwar, Shailesh V. Shrikhande, Amit Dutt

Published in: Infectious Agents and Cancer | Issue 1/2016

Abstract

Background

We earlier proposed a genetic model for gallbladder carcinogenesis and its dissemination cascade. However, the association of gallbladder cancer and ‘inflammatory stimulus’ to drive the initial cascade in the model remained unclear. A recent study suggested infection with Salmonella can lead to changes in the host signalling pathways in gallbladder cancer.

Findings

We examined the whole exomes of 26 primary gall bladder tumour and paired normal samples for presence of 143 HPV (Human papilloma virus) types along with 6 common Salmonella serotypes (S. typhi Ty2, S. typhi CT18, S. typhimurium LT2, S. choleraesuis SCB67, S. paratyphi TCC, and S. paratyphi SPB7) using a computational subtraction pipeline based on the HPVDetector, we recently described. Based on our evaluation of 26 whole exome gallbladder primary tumours and matched normal samples: association of typhoidal Salmonella species were found in 11 of 26 gallbladder cancer samples, and non-typhoidal Salmonella species in 12 of 26 gallbladder cancer, with 6 samples were found co-infected with both.

Conclusions

We present the first evidence to support the association of non-typhoidal Salmonella species along with typhoidal strains in gallbladder cancer. Salmonella infection in the chronic carrier state fits the role of the ‘inflammatory stimulus’ in the genetic model for gallbladder carcinogenesis that may play a role in gallbladder cancer analogous to Helicobacter pylori in gastric cancer.

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Title: Non-typhoidal Salmonella DNA traces in gallbladder cancer
Authors: Prajish Iyer
Savio George Barreto
Bikram Sahoo
Pratik Chandrani
Mukta R. Ramadwar
Shailesh V. Shrikhande
Amit Dutt
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Infectious Agents and Cancer / Issue 1/2016
Electronic ISSN: 1750-9378
DOI: https://doi.org/10.1186/s13027-016-0057-x

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Abstract

Background

Findings

Conclusions

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