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Orphanet Journal of Rare Diseases
Published in: Orphanet Journal of Rare Diseases 1/2019

Open Access 01-12-2019 | Lymphoma | Research

Experiences in the treatment of refractory chylothorax associated with lymphoproliferative disorders

Authors: Jana Pospiskova, Lukas Smolej, David Belada, Martin Simkovic, Monika Motyckova, Alice Sykorova, Pavla Stepankova, Pavel Zak

Published in: Orphanet Journal of Rare Diseases | Issue 1/2019

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Abstract

Background

Chylothorax is a rare condition which can be associated with malignant lymphoproliferative disorders (LPDs). We retrospectively analyzed the results of the conservative treatment of 10 patients with persistent non-traumatic malignant chylothorax.

Results

Conservative treatment lead to a decline of chylothorax after mean of 66 days and consisted of the treatment of the underlying disease and of simultaneous long-term supportive care (drainage of the thoracic cavity, dietary measures and nutrition management). In most cases (80%), chylothorax disappeared only after a successful therapeutic response of the underlying disease. Low-dose radiotherapy had very good effects in two patients.

Conclusion

Conservative treatment of malignant chylothorax can be considered a suitable method. Based on our results, successful treatment of the lymphoproliferative disorder seems to be a very important factor for the disappearance of chylothorax.
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Metadata
Title
Experiences in the treatment of refractory chylothorax associated with lymphoproliferative disorders
Authors
Jana Pospiskova
Lukas Smolej
David Belada
Martin Simkovic
Monika Motyckova
Alice Sykorova
Pavla Stepankova
Pavel Zak
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Orphanet Journal of Rare Diseases / Issue 1/2019
Electronic ISSN: 1750-1172
DOI
https://doi.org/10.1186/s13023-018-0991-3

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