Open Access 01-12-2015 | Letter to the Editor
Rare diseases and orphan drugs: 500 years ago
Published in: Orphanet Journal of Rare Diseases | Issue 1/2015
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In 1581 Rembert Dodoens wrote “Medicinalium observationum exempla rara, recognita et aucta” a Latin book about the diagnosis and treatment of disorders with a low prevalence.