Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Journal of Orthopaedic Surgery and Research
Published in: Journal of Orthopaedic Surgery and Research 1/2019

Open Access 01-12-2019 | Osteoporosis | Research article

Therapeutic effect of percutaneous kyphoplasty combined with anti-osteoporosis drug on postmenopausal women with osteoporotic vertebral compression fracture and analysis of postoperative bone cement leakage risk factors: a retrospective cohort study

Authors: Shuaihao Huang, Xiaowen Zhu, Dan Xiao, Jianxiong Zhuang, Guoyan Liang, Changxiang Liang, Xiaoqing Zheng, Yuhong Ke, Yunbing Chang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2019

Login to get access

Abstract

Background

The purpose of this study is to explore the therapeutic effect of percutaneous kyphoplasty (PKP) combined with anti-osteoporosis drug, zoledronic acid, on postmenopausal women with osteoporotic vertebral compression fracture (OVCF) and to perform an analysis of postoperative bone cement leakage risk factors.

Methods

A total of 112 OVCF patients, according to therapeutic regimens, were divided into control group (n = 52, treated with PKP) and observation group (n = 60, treated with PKP and zoledronic acid injection).

Results

Postoperative tumor necrosis factor-α and interleukin-6 levels were significantly decreased in the two groups, compared with those before treatment (both P < 0.05); bone mineral density (BMD), serum bone gla protein (BGP), and vertebral height ratio of injured vertebrae were significantly increased, and procollagen type I N-terminal propeptide (PINP), Cobb angle, visual analogue scale/score (VAS), and Oswestry disability index (ODI) were significantly decreased compared with those before treatment (all P < 0.05). There were significantly higher changes in difference value of BMD, PINP, BGP, vertebral height ratio of injured vertebrae, Cobb angle, VAS, and ODI levels and significantly better therapeutic effect in the observation group than those in the control group (all P < 0.05). Multivariate logistic regression analysis showed that the use of zoledronic acid, vertebral height ratio of injured vertebrae, and ODI were independent factors affecting the therapeutic effect, and that the dosage of bone cement, and peripheral vertebrae wall damage were independent risk factors causing postoperative bone cement leakage. There were no significant differences in postoperative bone cement leakage rate between the two groups.

Conclusions

Peripheral vertebrae wall damage and the dosage of bone cement are independent risk factors causing bone cement leakage in OVCF patients treated with PKP. PKP combined with zoledronic acid has an improvement effect on the condition of postmenopausal women with OVCF and reduces the inflammation and pain in patients, which is beneficial to clinical treatment.
Literature
1.
Wong CC, McGirt MJ. Vertebral compression fractures: a review of current management and multimodal therapy. J Multidiscip Healthc. 2013;6:205–14.PubMedPubMedCentral
2.
Peng X. China’s demographic history and future challenges. Science (New York, NY). 2011;333(6042):581–7.CrossRef
3.
Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diab Endocrinol. 2017;5(7):513–23.CrossRef
4.
America’s Bone Health. The state of osteoporosis and low bone mass in our nation. Washington, DC: National Osteoporsis Foundation; 2002.
5.
Forciea MA, McLean RM, Qaseem A. Treatment of low bone density or osteoporosis to prevent fractures in men and women. Ann Intern Med. 2017;167(12):904.CrossRef
6.
Svensson HK, Olofsson EH, Karlsson J, Hansson T, Olsson LE. A painful, never ending story: older women's experiences of living with an osteoporotic vertebral compression fracture. Osteoporos Int. 2016;27(5):1729–36.CrossRef
7.
Gillespie CW, Morin PE. Trends and disparities in osteoporosis screening among women in the United States, 2008-2014. Am J Med. 2017;130(3):306–16.CrossRef
8.
Heilmeier U, Carpenter DR, Patsch JM, Harnish R, Joseph GB, Burghardt AJ, et al. Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures. Osteoporos Int. 2015;26(4):1283–93.CrossRef
9.
Buchbinder R, Johnston RV, Rischin KJ, Homik J, Jones CA, Golmohammadi K, et al. Percutaneous vertebroplasty for osteoporotic vertebral compression fracture. Cochrane Database Syst Rev. 2018;4:Cd006349.PubMed
10.
Ahn TK, Kim JO, Kim HW, Park HS, Shim JH, Ropper AE, et al. 3′-UTR polymorphisms of MTHFR and TS associated with osteoporotic vertebral compression fracture susceptibility in postmenopausal women. Int J Mol Sci. 2018;19(3):824.CrossRef
11.
Yang EZ, Xu JG, Huang GZ, Xiao WZ, Liu XK, Zeng BF, et al. Percutaneous vertebroplasty versus conservative treatment in aged patients with acute osteoporotic vertebral compression fractures: a prospective randomized controlled clinical study. Spine. 2016;41(8):653–60.CrossRef
12.
Wang H, Sribastav SS, Ye F, Yang C, Wang J, Liu H, et al. Comparison of percutaneous vertebroplasty and balloon kyphoplasty for the treatment of single level vertebral compression fractures: a meta-analysis of the literature. Pain Physician. 2015;18(3):209–22.PubMed
13.
Yang H, Liu H, Wang S, Wu K, Meng B, Liu T. Review of percutaneous kyphoplasty in China. Spine. 2016;19:B52–b8.CrossRef
14.
Detao YU, Wang L, Xing Z. Clinical study of zoledronic acid combined with percutaneous vertebroplasty for osteoporotic vertebral compression fracture. China Pharm. 2017;28(29):4137–9.
15.
Liu ZX. Common diagnosis and classification methods in orthopedics and functional outcome scale. Beijing: Science and Technology Press; 2005.
16.
Sun M, Yang J, Wang J, Hao T, Jiang D, Bao G, et al. TNF-alpha is upregulated in T2DM patients with fracture and promotes the apoptosis of osteoblast cells in vitro in the presence of high glucose. Cytokine. 2016;80:35–42.CrossRef
17.
Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, et al. Distinct effects of IL-6 classic and trans-signaling in bone fracture healing. Am J Pathol. 2018;188(2):474–90.CrossRef
18.
McClung MR, Grauer A, Boonen S, Bolognese MA, Brown JP, Diez-Perez A, et al. Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 2014;370(5):412–20.CrossRef
19.
Krege JH, Lane NE, Harris JM, Miller PD. PINP as a biological response marker during teriparatide treatment for osteoporosis. Osteoporos Int. 2014;25(9):2159–71.CrossRef
20.
Wang F, Ren HQ, Shen XB. Effect of insulin combined alendronate sodium on bone mineral density and levels of serum BAP, TRAP-5b and BGP in aged patients with type 2 diabetes mellitus with osteoporosis. J Hainan Med Univ. 2016;22(13):62–4.
21.
Chen F, Dai Z, Kang Y, Lv G, Keller ET, Jiang Y. Effects of zoledronic acid on bone fusion in osteoporotic patients after lumbar fusion. Osteoporos Int. 2016;27(4):1469–76.CrossRef
22.
Chen LX, Li YL, Ning GZ, Li Y, Wu QL, Guo JX, et al. Comparative efficacy and tolerability of three treatments in old people with osteoporotic vertebral compression fracture: a network meta-analysis and systematic review. PLoS One. 2015;10(4):e0123153.CrossRef
23.
Wang CH, Ma JZ, Zhang CC, Nie L. Comparison of high-viscosity cement vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. Pain Physician. 2015;18(2):E187–94.PubMed
24.
Zhu SY, Zhong ZM, Wu Q, Chen JT. Risk factors for bone cement leakage in percutaneous vertebroplasty: a retrospective study of four hundred and eighty five patients. Int Orthop. 2016;40(6):1205–10.CrossRef
25.
Zheng Y, Zhang Y, Lin J, Shi JH, Wang QK. Relative risk factors of bone cement leakage after vertebroplasty and kyphoplasty. Chin J Trauma. 2015;31(4):312–6.
26.
Sun ZY, Qian ZL, Zhu XY, Chen KW, Pi B, Yang HL. Kyphoplasty with bone cement repairs osteoporotic thoracolumbar vertebral fractures associated with peripheral wall damage: a 2-year follow-up. Chin J Tissue Eng Res. 2016;20:7076–82.
Metadata
Title
Therapeutic effect of percutaneous kyphoplasty combined with anti-osteoporosis drug on postmenopausal women with osteoporotic vertebral compression fracture and analysis of postoperative bone cement leakage risk factors: a retrospective cohort study
Authors
Shuaihao Huang
Xiaowen Zhu
Dan Xiao
Jianxiong Zhuang
Guoyan Liang
Changxiang Liang
Xiaoqing Zheng
Yuhong Ke
Yunbing Chang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2019
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-019-1499-9

Other articles of this Issue 1/2019

Journal of Orthopaedic Surgery and Research 1/2019 Go to the issue

Research article

Comparison of one-stage versus two-stage procedure for the management of patients with rotator cuff tear and concomitant shoulder stiffness

Research article

BMSC affinity peptide-functionalized β-tricalcium phosphate scaffolds promoting repair of osteonecrosis of the femoral head

Study protocol

Evaluation of the effectiveness of hip and knee implant models used in Catalonia: a protocol for a prospective registry-based study

Research article

Gait oscillation analysis during gait and stair-stepping in elder patients with knee osteoarthritis

Research article

TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway

Research article

Comparison of the operative time for open door laminoplasty using titanium plate spacers or hydroxyapatite block spacers: a retrospective study