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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2019 | Osteoarthrosis | Research article

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

Authors: Quan Quan Song, Li Yan Sun, Chun Hui Li, Yu Jiao Liu, Si Lu Cui, Yun Qi Liu, Yan Hong Cao, Jun Rui Pei, Yue Wang, Wei Lian, Zhe Jiao, Qing Deng, Jun Yu

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2019

Abstract

Background

Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA). Therefore, this study aimed to identify changes in the levels of potential urinary biomarkers for OA, including C-telopeptide of type II collagen (uCTX-II), type II collagen cleavage neoepitope (uC2C), pyridinoline (uPYD), and uHelix-II, among adults with KBD.

Methods

Urinary samples of 83 external control (EC) subjects, 91 KBD patients, and 86 internal control (IC) subjects were tested by ELISA after the subjects completed a questionnaire and X-ray examination.

Results

The medians of the four markers in the KBD group were higher than those in the EC group and those in the IC group. The medians in the grade II KBD group were higher than those in the grade I group but were not statistically significant (P = 0.301, P = 0.408, P = 0.204, and P = 0.898 for uCTX-II, uC2C, uPYD, and uHelix-II, respectively). The area under the curve (AUC) of uCTX-II (0.775) was higher than that of the others (0.672, 0.639, and 0.628 for uC2C, uPYD, and uHelix-II, respectively).

Conclusion

The levels of uCTX-II, uC2C, uPYD, and uHelix-II were elevated in adults with KBD and showed an increasing trend as the severity of KBD increased. The prediction accuracy of uCTX-II was more useful than that of the others for assisting in the diagnosis of KBD.

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Title: The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study
Authors: Quan Quan Song
Li Yan Sun
Chun Hui Li
Yu Jiao Liu
Si Lu Cui
Yun Qi Liu
Yan Hong Cao
Jun Rui Pei
Yue Wang
Wei Lian
Zhe Jiao
Qing Deng
Jun Yu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Osteoarthrosis
Osteoarthrosis
Biomarkers
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2019
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-019-1392-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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