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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2019 | Osteoarthrosis | Research article

LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis

Authors: Yu Xiao, Yucheng Bao, Liang Tang, Li Wang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2019

Abstract

Purpose

MIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis.

Results

MIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls. Reduced levels of MIR4435-2HG expression effectively distinguished osteoarthritis patients from the control group. Expression levels of MIR4435-2HG increased after treatment. Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes.

Conclusion

MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis.

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Title: LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
Authors: Yu Xiao
Yucheng Bao
Liang Tang
Li Wang
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Osteoarthrosis
Osteoarthrosis
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2019
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-019-1278-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis

Abstract

Purpose

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Results

Conclusion

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