Skip to main content
Top
Published in: Journal of Orthopaedic Surgery and Research 1/2018

Open Access 01-12-2018 | Research article

Comparison of tourniquet application only during cementation and long-duration tourniquet application in total knee arthroplasty: a meta-analysis

Authors: Cong Wang, Chenhe Zhou, Hao Qu, Shigui Yan, Zhijun Pan

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2018

Login to get access

Abstract

Background

Tourniquet is widely used by orthopedic surgeons in total knee arthroplasty (TKA). However, there are still controversies on the optimal timing of tourniquet application. The aim of this meta-analysis was to compare the effect and safety of tourniquet application only during cementation with long-duration tourniquet application in TKA.

Methods

An electronic literature search of PubMed, the Cochrane library, Embase, and Web of Science was conducted in July 2017. All randomized controlled trials (RCTs) comparing tourniquet application only during cementation with long-duration tourniquet application in TKA were included. RevMan 5.3 software was selected to perform the meta-analysis.

Results

Seven studies involving 440 TKAs were included for meta-analysis. The results suggested that although significant less intraoperative and total blood loss were observed with long-duration tourniquet application, tourniquet application only during cementation would not increase the number of transfusion and operation time. Tourniquet application only during cementation results in less knee pain on post-operative day 1 (POD 1), less time needed to achieve straight-leg raise, and less minor complications following TKA.

Conclusions

Tourniquet application only during cementation might reduce the rate of minor complications and have faster functional recovery during the early rehabilitation period following TKA, but it could not limit intraoperative and total blood loss. No definitive conclusions can be drawn based on the current evidences. Further, large well-designed RCTs with extensive follow-up are still needed to validate this research.
Literature
1.
go back to reference Noticewala MS, Nyce JD, Wang W, Geller JA, Macaulay W. Predicting need for allogeneic transfusion after total knee arthroplasty. J Arthroplast. 2012;27:961–7.CrossRef Noticewala MS, Nyce JD, Wang W, Geller JA, Macaulay W. Predicting need for allogeneic transfusion after total knee arthroplasty. J Arthroplast. 2012;27:961–7.CrossRef
2.
go back to reference Alcelik I, Pollock RD, Sukeik M, et al. A comparison of outcomes with and without a tourniquet in total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials. J Arthroplasty. 2012;27(3):331–40.CrossRefPubMed Alcelik I, Pollock RD, Sukeik M, et al. A comparison of outcomes with and without a tourniquet in total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials. J Arthroplasty. 2012;27(3):331–40.CrossRefPubMed
3.
go back to reference Ochoa J, Fowler TJ, Gilliatt RW. Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat. 1972;113:433–55.PubMedPubMedCentral Ochoa J, Fowler TJ, Gilliatt RW. Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat. 1972;113:433–55.PubMedPubMedCentral
4.
go back to reference Naresh Kumar S, Chapman J, Rawlins I. Vascular injuries in total knee arthroplasty: a review of the problem with special reference to the possible effects of the tourniquet. J Arthroplasty. 1998;13:211–6.CrossRef Naresh Kumar S, Chapman J, Rawlins I. Vascular injuries in total knee arthroplasty: a review of the problem with special reference to the possible effects of the tourniquet. J Arthroplasty. 1998;13:211–6.CrossRef
5.
go back to reference Tamvakopoulos GS, Toms AP, Glasgow M. Subcutaneous thigh fat necrosis as a result of tourniquet control during total knee arthroplasty. Ann R Coll Surg Engl. 2005;87(5):W11–3.CrossRefPubMedPubMedCentral Tamvakopoulos GS, Toms AP, Glasgow M. Subcutaneous thigh fat necrosis as a result of tourniquet control during total knee arthroplasty. Ann R Coll Surg Engl. 2005;87(5):W11–3.CrossRefPubMedPubMedCentral
6.
go back to reference Saunders KC, Louis DL, Weingarden SI, Waylonis GW. Effect of tourniquet time on postoperative quadriceps function. Clin Orthop Relat Res. 1979;143:194–9. Saunders KC, Louis DL, Weingarden SI, Waylonis GW. Effect of tourniquet time on postoperative quadriceps function. Clin Orthop Relat Res. 1979;143:194–9.
7.
go back to reference Kageyama K, Nakajima Y, Shibasaki M, Hashimoto S, Mizobe T. Increased platelet, leukocyte, and endothelial cell activity are associated with increased coagulability in patients after total knee arthroplasty. J Thromb Haemost. 2007;5:738–45.CrossRefPubMed Kageyama K, Nakajima Y, Shibasaki M, Hashimoto S, Mizobe T. Increased platelet, leukocyte, and endothelial cell activity are associated with increased coagulability in patients after total knee arthroplasty. J Thromb Haemost. 2007;5:738–45.CrossRefPubMed
8.
go back to reference Horlocker TT, Hebl JR, Gali B, et al. Anesthetic, patient, and surgical risk factors for neurologic complications after prolonged total tourniquet time during total knee arthroplasty. Anesth Analg. 2006;102(3):950–5.CrossRefPubMed Horlocker TT, Hebl JR, Gali B, et al. Anesthetic, patient, and surgical risk factors for neurologic complications after prolonged total tourniquet time during total knee arthroplasty. Anesth Analg. 2006;102(3):950–5.CrossRefPubMed
9.
go back to reference Christodoulou AG, Ploumis AL, Terzidis IP, Chantzidis P, Metsovitis SR, Nikiforos DG. The role of timing of tourniquet release and cementing on perioperative blood loss in total knee replacement. Knee. 2004;11(4):313–7.CrossRefPubMed Christodoulou AG, Ploumis AL, Terzidis IP, Chantzidis P, Metsovitis SR, Nikiforos DG. The role of timing of tourniquet release and cementing on perioperative blood loss in total knee replacement. Knee. 2004;11(4):313–7.CrossRefPubMed
10.
go back to reference Fan Y, Jin J, Sun Z, Li W, Lin J, Weng X, Qiu G. The limited use of a tourniquet during total knee arthroplasty: a randomized controlled trial. Knee. 2014;21(6):1263–8.CrossRefPubMed Fan Y, Jin J, Sun Z, Li W, Lin J, Weng X, Qiu G. The limited use of a tourniquet during total knee arthroplasty: a randomized controlled trial. Knee. 2014;21(6):1263–8.CrossRefPubMed
12.
go back to reference Mittal R, Ko V, Adie S, Naylor J, Dave J, Dave C, et al. Tourniquet application only during cement fixation in total knee arthroplasty: a double-blind, randomized controlled trial. ANZ J Surg. 2012;82(6):428–33.CrossRefPubMed Mittal R, Ko V, Adie S, Naylor J, Dave J, Dave C, et al. Tourniquet application only during cement fixation in total knee arthroplasty: a double-blind, randomized controlled trial. ANZ J Surg. 2012;82(6):428–33.CrossRefPubMed
13.
go back to reference Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;10:1006–12.CrossRef Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;10:1006–12.CrossRef
14.
go back to reference Gross JB. Estimating allowable blood loss: corrected for dilution. Anesthesiology. 1983;58(3):277–80.CrossRefPubMed Gross JB. Estimating allowable blood loss: corrected for dilution. Anesthesiology. 1983;58(3):277–80.CrossRefPubMed
16.
go back to reference Hakkalamani S, Clark V, Pradhan N. Short versus standard duration tourniquet use during Total Knee Replacement: A pilot study. Acta Orthop Belg. 2015;81(1):52–6.PubMed Hakkalamani S, Clark V, Pradhan N. Short versus standard duration tourniquet use during Total Knee Replacement: A pilot study. Acta Orthop Belg. 2015;81(1):52–6.PubMed
17.
go back to reference Harvey EJ, Leclerc J, Brooks CE, Burke DL. Effect of tourniquet use on blood loss and incidence of deep vein thrombosis in total knee arthroplasty. J Arthroplast. 1997;12(3):291–6.CrossRef Harvey EJ, Leclerc J, Brooks CE, Burke DL. Effect of tourniquet use on blood loss and incidence of deep vein thrombosis in total knee arthroplasty. J Arthroplast. 1997;12(3):291–6.CrossRef
18.
go back to reference Kvederas G, Porvaneckas N, Andrijauskas A, Svensen CH, et al. A randomized double-blind clinical trial of tourniquet application strategies for total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2013;21(12):2790–9.CrossRefPubMed Kvederas G, Porvaneckas N, Andrijauskas A, Svensen CH, et al. A randomized double-blind clinical trial of tourniquet application strategies for total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2013;21(12):2790–9.CrossRefPubMed
19.
go back to reference Tarwala R, Dorr LD, Gilbert PK, Wan Z, Long WT. Tourniquet use during cementation only during total knee arthroplasty: a randomized trial. Clin Orthop Relat Res. 2014;472(1):169–74.CrossRefPubMed Tarwala R, Dorr LD, Gilbert PK, Wan Z, Long WT. Tourniquet use during cementation only during total knee arthroplasty: a randomized trial. Clin Orthop Relat Res. 2014;472(1):169–74.CrossRefPubMed
20.
go back to reference Yi S, Tan J, Chen C, Chen H, Huang W. The use of pneumatic tourniquet in total knee arthroplasty: a meta-analysis. Arch Orthop Trauma Surg. 2014;134(10):1469–76.CrossRefPubMed Yi S, Tan J, Chen C, Chen H, Huang W. The use of pneumatic tourniquet in total knee arthroplasty: a meta-analysis. Arch Orthop Trauma Surg. 2014;134(10):1469–76.CrossRefPubMed
21.
go back to reference Zan PF, Yang Y, Fu D, Yu X, Li GD. Releasing of tourniquet before wound closure or not in total knee arthroplasty: a meta-analysis of randomized controlled trials. J Arthroplast. 2015;30(1):31–7.CrossRef Zan PF, Yang Y, Fu D, Yu X, Li GD. Releasing of tourniquet before wound closure or not in total knee arthroplasty: a meta-analysis of randomized controlled trials. J Arthroplast. 2015;30(1):31–7.CrossRef
22.
go back to reference Tai TW, Chang CW, Lai KA, Lin CJ, Yang CY. Effects of tourniquet use on blood loss and soft-tissue damage in total knee arthroplasty: a randomized controlled trial. J Bone Joint Surg Am. 2012;94(24):2209–15.CrossRefPubMed Tai TW, Chang CW, Lai KA, Lin CJ, Yang CY. Effects of tourniquet use on blood loss and soft-tissue damage in total knee arthroplasty: a randomized controlled trial. J Bone Joint Surg Am. 2012;94(24):2209–15.CrossRefPubMed
23.
go back to reference Vandenbussche E, Duranthon LD, Couturier M, Pidhorz L, Augereau B. The effect of tourniquet use in total knee arthroplasty. Int Orthop. 2002;26(5):306–9.CrossRefPubMedPubMedCentral Vandenbussche E, Duranthon LD, Couturier M, Pidhorz L, Augereau B. The effect of tourniquet use in total knee arthroplasty. Int Orthop. 2002;26(5):306–9.CrossRefPubMedPubMedCentral
24.
go back to reference Silver R, de la Garza J, Rang M, Koreska J. Limb swelling after release of a tourniquet. Clin Orthop Relat Res. 1986;206:86–9. Silver R, de la Garza J, Rang M, Koreska J. Limb swelling after release of a tourniquet. Clin Orthop Relat Res. 1986;206:86–9.
25.
go back to reference Aglietti P, Baldini A, Vena LM, Abbate R, Fedi S, Falciani M. Effect of tourniquet use on activation of coagulation in total knee replacement. Clin Orthop Relat Res. 2000;371:169–77.CrossRef Aglietti P, Baldini A, Vena LM, Abbate R, Fedi S, Falciani M. Effect of tourniquet use on activation of coagulation in total knee replacement. Clin Orthop Relat Res. 2000;371:169–77.CrossRef
26.
go back to reference Klenerman L, Chakrabarti R, Mackie I, Brozovic M, Stirling Y. Changes in haemostatic system after application of a tourniquet. Lancet. 1977;1(8019):970–2.CrossRefPubMed Klenerman L, Chakrabarti R, Mackie I, Brozovic M, Stirling Y. Changes in haemostatic system after application of a tourniquet. Lancet. 1977;1(8019):970–2.CrossRefPubMed
27.
go back to reference Fahmy NR, Patel DG. Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg Am. 1981;63(3):461–5.CrossRefPubMed Fahmy NR, Patel DG. Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg Am. 1981;63(3):461–5.CrossRefPubMed
28.
go back to reference Chang C, Lan S, Tai T, Lai K, Yang C. An effective method to reduce ischemia time during total knee arthroplasty. J Formos Med Assoc. 2012;111(1):19–23.CrossRefPubMed Chang C, Lan S, Tai T, Lai K, Yang C. An effective method to reduce ischemia time during total knee arthroplasty. J Formos Med Assoc. 2012;111(1):19–23.CrossRefPubMed
29.
go back to reference Risberg B. The response of the fibrinolytic system in trauma. Acta Chir Scand Suppl. 1984;522:245. Risberg B. The response of the fibrinolytic system in trauma. Acta Chir Scand Suppl. 1984;522:245.
30.
go back to reference Moráis S, Ortega-Andreu M, Rodríguez- Merchán EC, et al. Blood transfusion after primary total knee arthroplasty can be significantly minimised through a multimodal blood-loss prevention approach. Int Orthop. 2014;38(2):347–54.CrossRefPubMed Moráis S, Ortega-Andreu M, Rodríguez- Merchán EC, et al. Blood transfusion after primary total knee arthroplasty can be significantly minimised through a multimodal blood-loss prevention approach. Int Orthop. 2014;38(2):347–54.CrossRefPubMed
31.
go back to reference Ledin H, Aspenberg P, Good L. Tourniquet use in total knee replacement does not improve fixation, but appears to reduce final range of motion. Acta Orthop. 2012;83(5):499–503.CrossRefPubMedPubMedCentral Ledin H, Aspenberg P, Good L. Tourniquet use in total knee replacement does not improve fixation, but appears to reduce final range of motion. Acta Orthop. 2012;83(5):499–503.CrossRefPubMedPubMedCentral
32.
go back to reference Dennis DA, Kittelson AJ, Yang CC, Miner TM, Kim RH, Stevens-Lapsley JE. Does tourniquet use in TKA affect recovery of lower extremity strength and function? A randomized trial. Clin Orthop Relat Res. 2016;474(1):69–77.CrossRefPubMed Dennis DA, Kittelson AJ, Yang CC, Miner TM, Kim RH, Stevens-Lapsley JE. Does tourniquet use in TKA affect recovery of lower extremity strength and function? A randomized trial. Clin Orthop Relat Res. 2016;474(1):69–77.CrossRefPubMed
33.
go back to reference Klenerman L, Biswas M, Hulands GH, Rhodes AM. Systemic and local effects of the application of a tourniquet. J. Bone Joint Surg. Br. 1980;62:385–8.CrossRefPubMed Klenerman L, Biswas M, Hulands GH, Rhodes AM. Systemic and local effects of the application of a tourniquet. J. Bone Joint Surg. Br. 1980;62:385–8.CrossRefPubMed
34.
go back to reference Patterson S, Klenerman L. The effect of pneumatic tourniquets on the ultrastructure of skeletal muscle. J Bone Joint Surg Br. 1979;61-B:178–83.CrossRefPubMed Patterson S, Klenerman L. The effect of pneumatic tourniquets on the ultrastructure of skeletal muscle. J Bone Joint Surg Br. 1979;61-B:178–83.CrossRefPubMed
35.
go back to reference Erskine JG, Fraser C, Simpson R, Protheroe K, Walker ID. Blood loss with knee joint replacement. J R Coll Surg Edinb. 1981;26(5):295–7.PubMed Erskine JG, Fraser C, Simpson R, Protheroe K, Walker ID. Blood loss with knee joint replacement. J R Coll Surg Edinb. 1981;26(5):295–7.PubMed
36.
go back to reference Pedowitz RA, Gershuni DH, Schmidt AH, Friden J, Rydevik BL, Hargens AR. Muscle injury induced beneath and distal to a pneumatic tourniquet: a quantitative animal study of effects of tourniquet pressure and duration. J Hand Surg Am. 1991;16:610–21.CrossRefPubMed Pedowitz RA, Gershuni DH, Schmidt AH, Friden J, Rydevik BL, Hargens AR. Muscle injury induced beneath and distal to a pneumatic tourniquet: a quantitative animal study of effects of tourniquet pressure and duration. J Hand Surg Am. 1991;16:610–21.CrossRefPubMed
37.
go back to reference Abbas K, Raza H, Umer M, Hafeez K. Effect of early release of tourniquet in total knee arthroplasty. J Coll Physicians Surg Pak. 2013;23(8):562–5.PubMed Abbas K, Raza H, Umer M, Hafeez K. Effect of early release of tourniquet in total knee arthroplasty. J Coll Physicians Surg Pak. 2013;23(8):562–5.PubMed
38.
go back to reference Clarke MT, Longstaff L, Edwards D, Rushton N. Tourniquet-induced wound hypoxia after total knee replacement. J Bone Joint Surg Br. 2001;83(1):40–4.CrossRefPubMed Clarke MT, Longstaff L, Edwards D, Rushton N. Tourniquet-induced wound hypoxia after total knee replacement. J Bone Joint Surg Br. 2001;83(1):40–4.CrossRefPubMed
39.
go back to reference Olivecrona C, Lapidus LJ, Benson L, Blomfeldt R. Tourniquet time affects postoperative complications after knee arthroplasty. Int Orthop. 2013;37(5):827–32.CrossRefPubMedPubMedCentral Olivecrona C, Lapidus LJ, Benson L, Blomfeldt R. Tourniquet time affects postoperative complications after knee arthroplasty. Int Orthop. 2013;37(5):827–32.CrossRefPubMedPubMedCentral
40.
go back to reference Katsumata S, Nagashima M, Kato K, Tachihara A, Wauke K, Saito S, Jin E, Kawanami O, Ogawa R, Yoshino S. Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism. Acta Anaesthesiol Scand. 2005;49(4):510–6.CrossRefPubMed Katsumata S, Nagashima M, Kato K, Tachihara A, Wauke K, Saito S, Jin E, Kawanami O, Ogawa R, Yoshino S. Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism. Acta Anaesthesiol Scand. 2005;49(4):510–6.CrossRefPubMed
41.
go back to reference Wauke K, Nagashima M, Kato N, Ogawa R, Yoshino S. Comparative study between thromboembolism and total knee arthroplasty with or without tourniquet in rheumatoid arthritis patients. Arch Orthop Trauma Surg. 2002;122(8):442–6.CrossRefPubMed Wauke K, Nagashima M, Kato N, Ogawa R, Yoshino S. Comparative study between thromboembolism and total knee arthroplasty with or without tourniquet in rheumatoid arthritis patients. Arch Orthop Trauma Surg. 2002;122(8):442–6.CrossRefPubMed
Metadata
Title
Comparison of tourniquet application only during cementation and long-duration tourniquet application in total knee arthroplasty: a meta-analysis
Authors
Cong Wang
Chenhe Zhou
Hao Qu
Shigui Yan
Zhijun Pan
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2018
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-018-0927-6

Other articles of this Issue 1/2018

Journal of Orthopaedic Surgery and Research 1/2018 Go to the issue