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Journal of Orthopaedic Surgery and Research
Published in: Journal of Orthopaedic Surgery and Research 1/2018

Open Access 01-12-2018 | Review

Scaffolds for the repair of bone defects in clinical studies: a systematic review

Authors: Jian-Hua Zeng, Shi-Wei Liu, Long Xiong, Peng Qiu, Ling-Hua Ding, Shi-Lang Xiong, Jing-Tang Li, Xin-Gen Liao, Zhi-Ming Tang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2018

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Abstract

Background

This systematic review aims to summarize the clinical studies on the use of scaffolds in the repair of bony defects.

Methods

The relevant articles were searched through PubMed database. The following keywords and search terms were used: “scaffolds,” “patient,” “clinic,” “bone repair,” “bone regeneration,” “repairing bone defect,” “repair of bone,” “osteanagenesis,” “osteanaphysis,” and “osteoanagenesis.” The articles were screened according to inclusion and exclusion criteria, performed by two reviewers.

Results

A total of 373 articles were obtained using PubMed database. After screening, 20 articles were identified as relevant for the purpose of this systematic review. We collected the data of biological scaffolds and synthetic scaffolds. There are eight clinical studies of biological scaffolds included collagen, gelatin, and cellular scaffolds for bone healing. In addition, 12 clinical studies of synthetic scaffolds on HAp, TCP, bonelike, and their complex scaffolds for repairing bone defects were involved in this systematic review.

Conclusions

There are a lot of clinical evidences showed that application of scaffolds had a good ability to facilitate bone repair and osteogenesis. However, the ideal and reliable guidelines are insufficiently applied and the number and quality of studies in this field remain to be improved.
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Metadata
Title
Scaffolds for the repair of bone defects in clinical studies: a systematic review
Authors
Jian-Hua Zeng
Shi-Wei Liu
Long Xiong
Peng Qiu
Ling-Hua Ding
Shi-Lang Xiong
Jing-Tang Li
Xin-Gen Liao
Zhi-Ming Tang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2018
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-018-0724-2

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