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Journal of Orthopaedic Surgery and Research
Published in: Journal of Orthopaedic Surgery and Research 1/2016

Open Access 01-12-2016 | Research article

Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone

Authors: Honglei Dou, Guowei Wang, Na Xing, Lina Zhang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2016

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Abstract

Background

The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones.

Methods

Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing.

Results

The therapeutic effect in the test group was superior to that in the control group.

Conclusions

Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.
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Metadata
Title
Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
Authors
Honglei Dou
Guowei Wang
Na Xing
Lina Zhang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2016
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-016-0492-9

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