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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2015 | Research article

Positive side effects of Ca antagonists for osteoarthritic joints—results of an in vivo pilot study

Authors: Kiriakos Daniilidis, Philipp Georges, Carsten O Tibesku, Peter Prehm

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2015

Abstract

Background

We have shown previously that some calcium antagonists inhibit hyaluronan export, loss of proteoglycans, and degradation of collagen from osteoarthritic cartilage. Clinically approved calcium antagonists normally are prescribed for cardiac arrhythmia. In the present study, we compared the effect of these drugs on osteoarthritic patients which had received no medication and patients which were also diagnosed for cardiac arrhythmias and were treated with calcium antagonists. The effects and the side effects of the used drugs were analyzed.

Method

We used the Lequesne questionnaire to examine patients with osteoarthritis (212 patients, control group receiving no calcium antagonists) and patients with cardiac arrhythmia and osteoarthritis (188 patients treated with various calcium antagonists). The answers of the questionnaires were transformed into the Lequesne scoring system quantifying the severity of the disease. The Lequesne score is a standardized questionnaire focused on osteoarthritis. It is a 24-scale questionary in which low scores indicate low functional activity.

Results

The data showed that the mean score of the control group (6.2) was higher than the treated group (5.2), the drugs differed in their efficiency. Verapamil had a slightly worse score and Azupamil, Escor, Felodipine, and Nifedipine showed no alteration. Adalat, Amlodipine, Carmen, Nitrendipin, and Norvasc lead to an improvement.

Conclusion

These results suggest that inhibition of hyaluronan export may have a beneficial effect on human osteoarthritis.

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Title: Positive side effects of Ca antagonists for osteoarthritic joints—results of an in vivo pilot study
Authors: Kiriakos Daniilidis
Philipp Georges
Carsten O Tibesku
Peter Prehm
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2015
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-014-0138-8

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Positive side effects of Ca antagonists for osteoarthritic joints—results of an in vivo pilot study

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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