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Open Access 01-12-2018 | Research

Re-irradiation in lung disease by SBRT: a retrospective, single institutional study

Authors: Donatella Caivano, Maurizio Valeriani, Sara De Matteis, Paolo Bonome, Ivana Russo, Vitaliana De Sanctis, Giuseppe Minniti, Mattia Falchetto Osti

Published in: Radiation Oncology | Issue 1/2018

Abstract

Background

The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities.

Methods

From April 2011 to December 2016, twenty-two patients received a re-irradiation by SBRT. Twenty- seven lesions were treated. The medium BED(10) of re-irradiation was 100.6 Gy (range: 48–151.2 Gy) and the medium EQD2(10) was 93.8 Gy (range: 40–126 Gy). In the previous treatment the medium BED(10) was 97.2 Gy (range: 40–120 Gy), the medium EQD2(10) was 81 Gy (range: 32.5–100 Gy). The median time between the first and the second treatment was 18 months.

Results

Local Control was reached in 18 out of 27 (66%) re-irradiated lesions, with rates of 67 and 54% at 1- year and 2- years respectively. The treatment was well tolerated; the maximum recorded toxicity was Grade 3.

Conclusions

Re- irradiation by SBRT may represent an option for the treatment of lung disease with good results in terms of LC and toxicity.

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Title: Re-irradiation in lung disease by SBRT: a retrospective, single institutional study
Authors: Donatella Caivano
Maurizio Valeriani
Sara De Matteis
Paolo Bonome
Ivana Russo
Vitaliana De Sanctis
Giuseppe Minniti
Mattia Falchetto Osti
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2018
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-018-1041-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Re-irradiation in lung disease by SBRT: a retrospective, single institutional study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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