Skip to main content
Top
Published in: Radiation Oncology 1/2017

Open Access 01-12-2017 | Research

Using field size factors to characterize the in-air fluence of a proton machine with a range shifter

Authors: Jiajian Shen, Jarrod M. Lentz, Yanle Hu, Wei Liu, Danairis Hernandez Morales, Joshua B. Stoker, Martin Bues

Published in: Radiation Oncology | Issue 1/2017

Login to get access

Abstract

Introduction

The range shifter (RS) is used to treat shallow tumors for a proton pencil beam scanning system (PBS). Adding RS certainly complicates the commissioning of the treatment planning system (TPS) because the spot sizes are significantly enlarged with RS. In this work, we present an efficient method to configure a commercial TPS for a PBS system with a fixed RS.

Methods

By combining a spiral delivery with customized control points, we were able to significantly improve measurement efficiency and obtain 250 field size factors (FSF) within three hours. The measured FSFs were used to characterize the proton fluence and fit the parameters for the double-Gaussian fluence model used in the TPS. Extensive validation was performed using FSFs measured in air and in water, absolute doses of spread-out Bragg peak (SOBP) fields, and the dose measurements carried out for patient-specific quality assurance (QA).

Results

The measured in-air FSFs agreed with the model’s prediction within 3% for all 250 FSFs, and within 2 for 94% of the FSFs. The agreement between model’s prediction and measurement was within 2% for the in-air and in-water FSFs and the absolute doses for SOBP beams. The patient-specific QA of 113 fields showed an excellent gamma passing rates (96.95 ± 2.51%) for the absolute dose comparisons with gamma criteria of 2 mm and 2%.

Conclusion

The excellent agreement between the model’s prediction and measurements proved the efficiency and accuracy of the proposed method of using FSFs to characterize the proton fluence and configure the TPS for a PBS system with fixed RS.
Literature
2.
go back to reference Lomax AJ, et al. Treatment planning and verification of proton therapy using spot scanning: initial experiences. Med Phys. 2004;31(11):3150–7.CrossRefPubMed Lomax AJ, et al. Treatment planning and verification of proton therapy using spot scanning: initial experiences. Med Phys. 2004;31(11):3150–7.CrossRefPubMed
4.
go back to reference Schaffner B. Proton dose calculation based on in-air fluence measurements. Phys Med Biol. 2008;53(6):1545–62.CrossRefPubMed Schaffner B. Proton dose calculation based on in-air fluence measurements. Phys Med Biol. 2008;53(6):1545–62.CrossRefPubMed
5.
go back to reference Varian. Proton Algorithm Reference Guide. Palo Alto: Varian Medical Systems; 2015. Varian. Proton Algorithm Reference Guide. Palo Alto: Varian Medical Systems; 2015.
6.
go back to reference Both S, et al. Development and clinical implementation of a universal bolus to maintain spot size during delivery of base of skull pencil beam scanning proton therapy. Int J Radiat Oncol Biol Phys. 2014;90(1):79–84.CrossRefPubMed Both S, et al. Development and clinical implementation of a universal bolus to maintain spot size during delivery of base of skull pencil beam scanning proton therapy. Int J Radiat Oncol Biol Phys. 2014;90(1):79–84.CrossRefPubMed
7.
go back to reference Sawakuchi GO, et al. Experimental characterization of the low-dose envelope of spot scanning proton beams. Phys Med Biol. 2010;55(12):3467–78.CrossRefPubMed Sawakuchi GO, et al. Experimental characterization of the low-dose envelope of spot scanning proton beams. Phys Med Biol. 2010;55(12):3467–78.CrossRefPubMed
8.
go back to reference Lin L, et al. Experimental characterization of two-dimensional spot profiles for two proton pencil beam scanning nozzles. Phys Med Biol. 2014;59(2):493–504.CrossRefPubMed Lin L, et al. Experimental characterization of two-dimensional spot profiles for two proton pencil beam scanning nozzles. Phys Med Biol. 2014;59(2):493–504.CrossRefPubMed
9.
go back to reference Pedroni E, et al. Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams. Phys Med Biol. 2005;50(3):541–61.CrossRefPubMed Pedroni E, et al. Experimental characterization and physical modelling of the dose distribution of scanned proton pencil beams. Phys Med Biol. 2005;50(3):541–61.CrossRefPubMed
10.
go back to reference Zhu XR, et al. Commissioning dose computation models for spot scanning proton beams in water for a commercially available treatment planning system. Med Phys. 2013;40(4):041723.CrossRefPubMedPubMedCentral Zhu XR, et al. Commissioning dose computation models for spot scanning proton beams in water for a commercially available treatment planning system. Med Phys. 2013;40(4):041723.CrossRefPubMedPubMedCentral
11.
go back to reference Lin LY, et al. Use of a novel two-dimensional ionization chamber array for pencil beam scanning proton therapy beam quality assurance. J Appl Clin Med Phys. 2015;16(3):270–6.CrossRef Lin LY, et al. Use of a novel two-dimensional ionization chamber array for pencil beam scanning proton therapy beam quality assurance. J Appl Clin Med Phys. 2015;16(3):270–6.CrossRef
12.
go back to reference Lewis D, et al. An efficient protocol for radiochromic film dosimetry combining calibration and measurement in a single scan. Med Phys. 2012;39(10):6339–50.CrossRefPubMed Lewis D, et al. An efficient protocol for radiochromic film dosimetry combining calibration and measurement in a single scan. Med Phys. 2012;39(10):6339–50.CrossRefPubMed
13.
go back to reference Lin LY, et al. A novel technique for measuring the low-dose envelope of pencil-beam scanning spot profiles. Phys Med Biol. 2013;58(12):N171–80.CrossRefPubMed Lin LY, et al. A novel technique for measuring the low-dose envelope of pencil-beam scanning spot profiles. Phys Med Biol. 2013;58(12):N171–80.CrossRefPubMed
14.
go back to reference Frank SJ, et al. Multifield Optimization Intensity Modulated Proton Therapy for Head and Neck Tumors: A Translation to Practice. Int J Radiat Oncol Biol Phys. 2014;89(4):846–53.CrossRefPubMedPubMedCentral Frank SJ, et al. Multifield Optimization Intensity Modulated Proton Therapy for Head and Neck Tumors: A Translation to Practice. Int J Radiat Oncol Biol Phys. 2014;89(4):846–53.CrossRefPubMedPubMedCentral
16.
go back to reference Shen J, et al. An efficient method to determine double Gaussian fluence parameters in the Eclipse proton pencil beam model. Med Phys. 2016;43(12):6544–51.CrossRefPubMed Shen J, et al. An efficient method to determine double Gaussian fluence parameters in the Eclipse proton pencil beam model. Med Phys. 2016;43(12):6544–51.CrossRefPubMed
Metadata
Title
Using field size factors to characterize the in-air fluence of a proton machine with a range shifter
Authors
Jiajian Shen
Jarrod M. Lentz
Yanle Hu
Wei Liu
Danairis Hernandez Morales
Joshua B. Stoker
Martin Bues
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2017
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-017-0783-2

Other articles of this Issue 1/2017

Radiation Oncology 1/2017 Go to the issue