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Substance Abuse Treatment, Prevention, and Policy
Published in: Substance Abuse Treatment, Prevention, and Policy 1/2020

01-12-2020 | Naltrexone | Review

Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review

Authors: Negin Farhadian, Sajad Moradi, Mohammad Hossein Zamanian, Vahid Farnia, Shahab Rezaeian, Maryam Farhadian, Mohsen Shahlaei

Published in: Substance Abuse Treatment, Prevention, and Policy | Issue 1/2020

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Abstract

Background

Because alcohol use disorders (AUDs) in patients living with HIV/AIDS are associated with a reduction in therapeutic outcomes and increases the risk of morbidity/mortality, finding an appropriate pharmacotherapy treatment for this disorder is necessary.

Objectives

This systematic review contains studies that examine the effects of pharmacological intervention (oral naltrexone (NTX) or injectable extended-release naltrexone (XR-NTX)) on the persons living with HIV and AUDs.

Methods

A systematic literature search using three electronic databases including Pubmed Medline, Scopus and the Cochrane Library and Google Scholar was conducted and includes articles published from 1995 to 2019. Records were collected by searching relevant keywords and those that meet the inclusion/exclusion criteria are included.

Results

Overall, in this systematic review, the results of 7 relevant studies including pilot and randomized controlled/clinical trials were summarized and reviewed. Among selected records 2 of these assessed the efficacy of NTX and 5 tested the XR-NTX effectiveness in treating AUDs among persons living with HIV (PLH). In summary, with some expectations, NTX and XR-NTX administration in persons living with HIV and AUDs led to reduced alcohol use, improved viral suppression, unchanged ART adherence and has no significant adverse events.

Conclusion

The findings of this systematic review suggest the beneficial effects and safety of the NTX and XR-NTX for treating AUDs in PLH. Further studies are needed in the future to focus on the treatment of AUDs in people living with HIV.
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Metadata
Title
Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review
Authors
Negin Farhadian
Sajad Moradi
Mohammad Hossein Zamanian
Vahid Farnia
Shahab Rezaeian
Maryam Farhadian
Mohsen Shahlaei
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Substance Abuse Treatment, Prevention, and Policy / Issue 1/2020
Electronic ISSN: 1747-597X
DOI
https://doi.org/10.1186/s13011-020-00266-6

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