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Open Access 01-12-2018 | Hypothesis

Bilateral Central Giant Cell Granuloma of the mandibular angle in three females from the same family

Authors: Simona Tecco, Silvia Caruso, Alessandro Nota, Pietro Leocata, Gianluca Cipollone, Roberto Gatto, Tommaso Cutilli

Published in: Head & Face Medicine | Issue 1/2018

Abstract

In literature there are few reports about multiple CGCG. But this is the first report of bilateral CGCG of the mandibular angles in three females from the same family.

This report describes three cases of females from the same family - a mother and two young daughters - with bilateral CGCG in their jaw angles. All the lesions were surgically removed and the histopathologic diagnosis was always identical: giant cell central granulomas, with patterns that were absolutely superimposable between them and with that of the mother.

The hypothesis is that this presentation of CGCG may be defined as hereditary bilateral CGCG of the mandibular angles (or also, cherubism-like lesions).

Clinically, cherubism most commonly manifests as a progressive and symmetrical enlargement of the mandible and/or the maxilla, and is first noted between between 2 and 7 years of age, after which, lesions proliferate and increase in size until puberty. The lesions subsequently begin to regress, fill with bone and remodel until age 30, when they are frequently not detectable.

Mandibular swelling produces plump cheeks and maxillary enlargement causes retraction of the lower eyelids and elevation of the pupils upward, resulting in an “angel-like” appearance reminiscent of the cherubs depicted in Renaissance art.

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Title: Bilateral Central Giant Cell Granuloma of the mandibular angle in three females from the same family
Authors: Simona Tecco
Silvia Caruso
Alessandro Nota
Pietro Leocata
Gianluca Cipollone
Roberto Gatto
Tommaso Cutilli
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Head & Face Medicine / Issue 1/2018
Electronic ISSN: 1746-160X
DOI: https://doi.org/10.1186/s13005-018-0171-7

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Bilateral Central Giant Cell Granuloma of the mandibular angle in three females from the same family

Abstract

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Abstract

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