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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2019

Open Access 01-12-2019 | Ovarian Cancer | Case Report

Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report

Authors: Kazuaki Suda, Hirofumi Nakaoka, Chihiro Hata, Natsumi Yahata, Masanori Isobe, Hitoshi Kameyama, Toshifumi Wakai, Teiichi Motoyama, Ituro Inoue, Kosuke Yoshihara, Takayuki Enomoto

Published in: Diagnostic Pathology | Issue 1/2019

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Abstract

Background

Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), which is considered as the main origin of ovarian HGSC. We reviewed the available literature and discussed about the origin of this rare disease.

Case presentation

A 58-year-old female with a 93 × 65 × 62 mm-solid tumor with a cystic part was located immediately dorsal to the rectum underwent bilateral salpingo-oophorectomy, total abdominal hysterectomy, and en bloc resection of the retroperitoneal tumor together with lower anterior resection of the rectum. Histological diagnosis was retroperitoneal HGSC and STIC at the right fallopian tube. Two deleterious somatic mutations in TP53 and BRCA2 genes were shared between retroperitoneal HGSC and STIC.

Conclusions

In addition to clinical features in the previous reports, our genetic findings suggest the origin of retroperitoneal HGSC might be STIC.
Literature
1.
Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, et al. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 2007;211(1):26–35.PubMedCrossRef
2.
Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol. 2007;31(2):161–9.PubMedCrossRef
3.
Kuhn E, Kurman RJ, Vang R, Sehdev AS, Han G, Soslow R, Wang TL, Shih Ie M. TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma--evidence supporting the clonal relationship of the two lesions. J Pathol. 2012;226(3):421–6.PubMedCrossRef
4.
McDaniel AS, Stall JN, Hovelson DH, Cani AK, Liu CJ, Tomlins SA, Cho KR. Next-generation sequencing of tubal intraepithelial carcinomas. JAMA Oncol. 2015;1(8):1128–32.PubMedPubMedCentralCrossRef
5.
Bashashati A, Ha G, Tone A, Ding J, Prentice LM, Roth A, Rosner J, Shumansky K, Kalloger S, Senz J, et al. Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling. J Pathol. 2013;231(1):21–34.PubMedPubMedCentralCrossRef
6.
Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, et al. High grade serous ovarian carcinomas originate in the fallopian tube. Nat Commun. 2017;8(1):1093.PubMedPubMedCentralCrossRef
7.
Ulbright TM, Morley DJ, Roth LM, Berkow RL. Papillary serous carcinoma of the retroperitoneum. Am J Clin Pathol. 1983;79(5):633–7.PubMedCrossRef
8.
Caruncho M, Pombo F, Arnal-Monreal F. Primary retroperitoneal serous cystadenocarcinoma of ‘ovarian-type’: US and CT findings. Eur J Radiol. 1993;17(2):115–6.PubMedCrossRef
9.
Kurosaki Y, Kuramoto K. Case report: serous cystadenocarcinoma of the retroperitoneum: CT and sonographic appearance. Clin Radiol. 1998;53(12):916–8.PubMedCrossRef
10.
Kaku M, Ohara N, Seima Y, Imanishi K, Tomura N, Kobayashi A, Yamasaki M, Hirata Y, Murao S. A primary retroperitoneal serous cystadenocarcinoma with clinically aggressive behavior. Arch Gynecol Obstet. 2004;270(4):302–6.PubMedCrossRef
11.
Demir MK, Unlu E, Genchellac H, Temizoz O, Ozdemir H: Primary serous papillary carcinoma of the retroperitoneum: magnetic resonance imaging findings with pathologic correlation. Australas Radiol 2007, 51 Spec No.:B71–B73.
12.
Iura A, Sasajima Y, Katsumata N, Kasamatsu T. Serous adenocarcinoma of the retroperitoneum, as a type of multifocal mullerian carcinoma. Int J Clin Oncol. 2009;14(3):254–7.PubMedCrossRef
13.
Arichi N, Yasumoto H, Mitsui Y, Hiraoka T, Honda S, Shiina H, Igawa M. A case of primary retroperitoneal serous adenocarcinoma. Int J Urol. 2011;18(12):844–6.PubMedCrossRef
14.
Suda K, Nakaoka H, Yoshihara K, Ishiguro T, Tamura R, Mori Y, Yamawaki K, Adachi S, Takahashi T, Kase H, et al. Clonal expansion and diversification of Cancer-associated mutations in endometriosis and Normal endometrium. Cell Rep. 2018;24(7):1777–89.PubMedCrossRef
15.
Lawrence MS, Stojanov P, Mermel CH, Robinson JT, Garraway LA, Golub TR, Meyerson M, Gabriel SB, Lander ES, Getz G. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014;505(7484):495–501.PubMedPubMedCentralCrossRef
16.
Ahmadloo S, Nakaoka H, Hayano T, Hosomichi K, You H, Utsuno E, Sangai T, Nishimura M, Matsushita K, Hata A, et al. Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2. J Hum Genet. 2017;62(5):561–7.PubMedCrossRef
17.
Saunders CT, Wong WS, Swamy S, Becq J, Murray LJ, Cheetham RK. Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs. Bioinformatics (Oxford England). 2012;28(14):1811–7.CrossRef
18.
19.
Novak M, Lester J, Karst AM, Parkash V, Hirsch MS, Crum CP, Karlan BY, Drapkin R. Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma. Gynecol Oncol. 2015;139(1):104–11.PubMedPubMedCentralCrossRef
20.
Sehdev AS, Kurman RJ, Kuhn E, Shih Ie M. Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. Mod Pathol. 2010;23(6):844–55.PubMedPubMedCentralCrossRef
21.
Schneider S, Heikaus S, Harter P, Heitz F, Grimm C, Ataseven B, Prader S, Kurzeder C, Ebel T, Traut A, et al. Serous tubal intraepithelial carcinoma associated with Extraovarian metastases. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2017;27(3):444–51.CrossRef
22.
Ayhan A, Gultekin M, Celik NY, Dursun P, Taskiran C, Aksan G, Yuce K: Occult metastasis in early ovarian cancers: risk factors and associated prognosis. Am J Obstet Gynecol 2007, 196(1):81.e81–86.
23.
Shroff R, Brooks RA, Zighelboim I, Powell MA, Thaker PH, Mutch DG, Massad LS. The utility of peritoneal biopsy and omentectomy in the upstaging of apparent early ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2011;21(7):1208–12.
24.
Powless CA, Bakkum-Gamez JN, Aletti GD, Cliby WA. Random peritoneal biopsies have limited value in staging of apparent early stage epithelial ovarian cancer after thorough exploration. Gynecol Oncol. 2009;115(1):86–9.PubMedCrossRef
25.
Kurman RJ, Vang R, Junge J, Hannibal CG, Kjaer SK, Shih Ie M. Papillary tubal hyperplasia: the putative precursor of ovarian atypical proliferative (borderline) serous tumors, noninvasive implants, and endosalpingiosis. Am J Surg Pathol. 2011;35(11):1605–14.PubMedPubMedCentralCrossRef
26.
McCoubrey A, Houghton O, McCallion K, McCluggage WG. Serous adenocarcinoma of the sigmoid mesentery arising in cystic endosalpingiosis. J Clin Pathol. 2005;58(11):1221–3.PubMedPubMedCentralCrossRef
27.
Soong TR, Howitt BE, Horowitz N, Nucci MR, Crum CP. The fallopian tube, "precursor escape" and narrowing the knowledge gap to the origins of high-grade serous carcinoma. Gynecol Oncol. 2018.
Metadata
Title
Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report
Authors
Kazuaki Suda
Hirofumi Nakaoka
Chihiro Hata
Natsumi Yahata
Masanori Isobe
Hitoshi Kameyama
Toshifumi Wakai
Teiichi Motoyama
Ituro Inoue
Kosuke Yoshihara
Takayuki Enomoto
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2019
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-019-0795-3

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