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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2015

Open Access 01-12-2015 | Research

CK19 is a sensitive marker for yolk sac tumours of the testis

Authors: Felix Bremmer, Philipp Ströbel, Hubertus Jarry, Jasmin Strecker, Nadine Gaisa, Arne Strauß, Stefan Schweyer, Heinz-Joachim Radzun, Carl-Ludwig Behnes

Published in: Diagnostic Pathology | Issue 1/2015

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Abstract

Background

Malignant germ cell tumours are the most common malignant tumours in young men. They are histologically divided into seminomas and non-seminomas. Non-seminomas are further subdivided into embryonic carcinomas, yolk sac tumours, chorionic carcinomas, and teratomas. For the therapeutic management it is essential to differentiate between these histological subtypes.

Methods

Investigated cases included normal testis (n = 50), intratubular germ cell neoplasia (n = 25), seminomas (n = 67), embryonic carcinomas (n = 56), yolk sac tumours (n = 29), chorionic carcinomas (n = 2), teratomas (n = 7) and four metastases of YST’s for their CK19 expression. In addition Leydig cell- (n = 10) and Sertoli cell- tumours (n = 4) were included in this study.

Results

All investigated seminomas, embryonic carcinomas as well as normal testis and intratubular germ cell neoplasias did not express CK19. In contrast, all investigated yolk sac tumours strongly expressed CK19 protein. These findings became also evident in mixed germ cell tumours consisting of embryonic carcinomas and yolk sac tumours, although CK19-expression could also be observed in analysed chorionic carcinomas and epithelial components of teratomas.

Conclusion

CK19 proved to be a sensitive marker to identify yolk sac tumours of the testis and to distinguish them from other germ cell tumours, especially seminomas and embryonic carcinomas.

Virtual slides

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Metadata
Title
CK19 is a sensitive marker for yolk sac tumours of the testis
Authors
Felix Bremmer
Philipp Ströbel
Hubertus Jarry
Jasmin Strecker
Nadine Gaisa
Arne Strauß
Stefan Schweyer
Heinz-Joachim Radzun
Carl-Ludwig Behnes
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2015
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-015-0243-y

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