Top

Fluids and Barriers of the CNS

Published in:

Open Access 01-12-2017 | Research

Characterization of cardiac- and respiratory-driven cerebrospinal fluid motion based on asynchronous phase-contrast magnetic resonance imaging in volunteers

Authors: Ken Takizawa, Mitsunori Matsumae, Saeko Sunohara, Satoshi Yatsushiro, Kagayaki Kuroda

Published in: Fluids and Barriers of the CNS | Issue 1/2017

Abstract

Background

A classification of cardiac- and respiratory-driven components of cerebrospinal fluid (CSF) motion has been demonstrated using echo planar imaging and time-spatial labeling inversion pulse techniques of magnetic resonance imaging (MRI). However, quantitative characterization of the two motion components has not been performed to date. Thus, in this study, the velocities and displacements of the waveforms of the two motions were quantitatively evaluated based on an asynchronous two-dimensional (2D) phase-contrast (PC) method followed by frequency component analysis.

Methods

The effects of respiration and cardiac pulsation on CSF motion were investigated in 7 healthy subjects under guided respiration using asynchronous 2D-PC 3-T MRI. The respiratory and cardiac components in the foramen magnum and aqueduct were separated, and their respective fractions of velocity and amount of displacement were compared.

Results

For velocity in the Sylvian aqueduct and foramen magnum, the fraction attributable to the cardiac component was significantly greater than that of the respiratory component throughout the respiratory cycle. As for displacement, the fraction of the respiratory component was significantly greater than that of the cardiac component in the aqueduct regardless of the respiratory cycle and in the foramen magnum in the 6- and 10-s respiratory cycles. There was no significant difference between the fractions in the 16-s respiratory cycle in the foramen magnum.

Conclusions

To separate cardiac- and respiratory-driven CSF motions, asynchronous 2D-PC MRI was performed under respiratory guidance. For velocity, the cardiac component was greater than the respiratory component. In contrast, for the amount of displacement, the respiratory component was greater.

Matsumae M, Sato O, Hirayama A, Hayashi N, Takizawa K, Atsumi H, Sorimachi T. Research into the physiology of cerebrospinal fluid reaches a new horizon: intimate exchange between cerebrospinal fluid and interstitial fluid may contribute to maintenance of homeostasis in the central nervous system. Neurol Med Chir (Tokyo). 2016;56:416–41.CrossRef

Matsumae M, Hirayama A, Atsumi H, Yatsushiro S, Kuroda K. Velocity and pressure gradients of cerebrospinal fluid assessed with magnetic resonance imaging. J Neurosurg. 2014;120:218–27.CrossRefPubMed

Atsumi H, Matsumae M, Hirayama A, Kuroda K. Measurements of intracranial pressure and compliance index using 1.5-T clinical MRI machine. Tokai J Exp Clin Med. 2014;39:34–43.PubMed

Yatsushiro S, Hirayama A, Matsumae M, Kuroda K. Visualization of pulsatile CSF motion separated by membrane-like structure based on four-dimensional phase-contrast (4D-PC) velocity mapping. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:6470–3.PubMed

Horie T, Kajihara N, Matsumae M, Obara M, Hayashi N, Hirayama A, Takizawa K, Takahara T, Yatsushiro S, Kuroda K. Magnetic resonance imaging technique for visualization of irregular cerebrospinal fluid motion in the ventricular system and subarachnoid space. World Neurosurg. 2017;97:523–31.CrossRefPubMed

Hayashi N, Matsumae M, Yatsushiro S, Hirayama A, Abdullah A, Kuroda K. Quantitative analysis of cerebrospinal fluid pressure gradients in healthy volunteers and patients with normal pressure hydrocephalus. Neurol Med Chir (Tokyo). 2015;55:657–62.CrossRef

Hirayama A, Matsumae M, Yatsushiro S, Abdulla A, Atsumi H, Kuroda K. Visualization of pulsatile csf motion around membrane-like structures with both 4D velocity mapping and time-slip technique. Magn Reson Med Sci. 2015;14:263–73.CrossRefPubMed

Yamada S, Miyazaki M, Yamashita Y, Ouyang C, Yui M, Nakahashi M, Shimizu S, Aoki I, Morohoshi Y, McComb JG. Influence of respiration on cerebrospinal fluid movement using magnetic resonance spin labeling. Fluids Barriers CNS. 2013;10:36.CrossRefPubMedPubMedCentral

Yildiz S, Thyagaraj S, Jin N, Zhong X, Heidari Pahlavian S, Martin BA, Loth F, Oshinski J, Sabra KG. Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real-time phase-contrast MRI. J Magn Reson Imaging. 2017;46:431–9.CrossRefPubMed

10.

Dreha-Kulaczewski S, Joseph AA, Merboldt KD, Ludwig HC, Gartner J, Frahm J. Inspiration is the major regulator of human CSF flow. J Neurosci. 2015;35:2485–91.CrossRefPubMed

11.

Chen L, Beckett A, Verma A, Feinberg DA. Dynamics of respiratory and cardiac CSF motion revealed with real-time simultaneous multi-slice EPI velocity phase contrast imaging. Neuroimage. 2015;122:281–7.CrossRefPubMedPubMedCentral

12.

Yatsushiro S, Sunohara S, Takizawa K, Matsumae M, Kajihara N, Kuroda K. Characterization of cardiac- and respiratory-driven cerebrospinal fluid motions using correlation mapping with asynchronous 2-dimensional phase contrast technique. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:3867–70.PubMed

13.

Abdullah A, Hirayama A, Yatsushiro S, Matsumae M, Kuroda K. Cerebrospinal fluid image segmentation using spatial fuzzy clustering method with improved evolutionary expectation maximization. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3359–62.PubMed

14.

Sunohara S, Yatsushiro S, Takizawa K, Matsumae M, Kajihara N, Kuroda K. Investigation of driving forces of cerebrospinal fluid motion by power and frequency mapping based on asynchronous phase contrast technique. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:1232–5.PubMed

15.

Beckett A, Chen L, Verma A, Feinberg DA. Velocity phase imaging with simultaneous multi-slice EPI reveals respiration driven motion in spinal CSF. Proc Intl Soc Mag Reson Med. 2015;23:4445.

16.

Tang C, Blatter DD, Parker DL. Accuracy of phase-contrast flow measurements in the presence of partial-volume effects. J Magn Reson Imaging. 1993;3:377–85.CrossRefPubMed

Title: Characterization of cardiac- and respiratory-driven cerebrospinal fluid motion based on asynchronous phase-contrast magnetic resonance imaging in volunteers
Authors: Ken Takizawa
Mitsunori Matsumae
Saeko Sunohara
Satoshi Yatsushiro
Kagayaki Kuroda
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Fluids and Barriers of the CNS / Issue 1/2017
Electronic ISSN: 2045-8118
DOI: https://doi.org/10.1186/s12987-017-0074-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Characterization of cardiac- and respiratory-driven cerebrospinal fluid motion based on asynchronous phase-contrast magnetic resonance imaging in volunteers

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2017

Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis

Is posture-related craniospinal compliance shift caused by jugular vein collapse? A theoretical analysis

Brain barriers and brain fluid research in 2016: advances, challenges and controversies

Hyperdynamic CSF motion profiles found in idiopathic normal pressure hydrocephalus and Alzheimer’s disease assessed by fluid mechanics derived from magnetic resonance images

Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus

Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis