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Published in: Virology Journal 1/2020

01-12-2020 | SARS-CoV-2 | Review

COVID-19 pandemic: current knowledge about the role of pets and other animals in disease transmission

Authors: Mulugeta Kiros, Henok Andualem, Teklehaimanot Kiros, Wasihun Hailemichael, Sisay Getu, Alene Geteneh, Derbie Alemu, Woldaregay Erku Abegaz

Published in: Virology Journal | Issue 1/2020

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Abstract

On 11 March 2020, the World Health Organization (WHO) announced Corona Virus Disease (COVID-19), a disease caused by a pathogen called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a pandemic. This ongoing pandemic has now been reported in 215 countries with more than 23 million confirmed cases and more than 803 thousand deaths worldwide as of August 22, 2020. Although efforts are undergoing, there is no approved vaccine or any specific antiretroviral drug to treat COVID-19 so far. It is now known that SARS-CoV-2 can affect not only humans but also pets and other domestic and wild animals, making it a one health global problem. Several published scientific evidence has shown that bats are the initial reservoir hosts of SARS-CoV-2, and pangolins are suggested as an intermediate hosts. So far, little is known concerning the role of pets and other animals in the transmission of COVID-19. Therefore, updated knowledge about the potential role of pets in the current outbreak will be of paramount importance for effective prevention and control of the disease. This review summarized the current evidence about the role of pets and other animals in the transmission of COVID-19.
Literature
1.
go back to reference Li H, Liu S-M, Yu X-H, Tang S-L, Tang C-K. Coronavirus disease 2019 (COVID-19): current status and future perspective. Int J Antimicrob Agents. 2019;2020:105951. Li H, Liu S-M, Yu X-H, Tang S-L, Tang C-K. Coronavirus disease 2019 (COVID-19): current status and future perspective. Int J Antimicrob Agents. 2019;2020:105951.
2.
go back to reference Lau SK, Feng Y, Chen H, Luk HK, Yang WH, Li KS, et al. Severe Acute Respiratory Syndrome (SARS) coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination. J Virol. 2015;89(20):10532–47.PubMedPubMedCentralCrossRef Lau SK, Feng Y, Chen H, Luk HK, Yang WH, Li KS, et al. Severe Acute Respiratory Syndrome (SARS) coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination. J Virol. 2015;89(20):10532–47.PubMedPubMedCentralCrossRef
5.
go back to reference Lai CC, Liu YH, Wang CY, Wang YH, Hsueh SC, Yen MY, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): facts and myths. J Microbiol Immunol Infect. 2020;53:404–12.PubMedPubMedCentralCrossRef Lai CC, Liu YH, Wang CY, Wang YH, Hsueh SC, Yen MY, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): facts and myths. J Microbiol Immunol Infect. 2020;53:404–12.PubMedPubMedCentralCrossRef
9.
go back to reference Helmy YA, Fawzy M, Elaswad A, Sobieh A, Kenney SP, Shehata AA. The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control. J Clin Med. 2020;9(4):1225.PubMedCentralCrossRef Helmy YA, Fawzy M, Elaswad A, Sobieh A, Kenney SP, Shehata AA. The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control. J Clin Med. 2020;9(4):1225.PubMedCentralCrossRef
11.
go back to reference Kakodkar P, Kaka N, Baig M. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19). Cureus. 2020;12(4):e7560.PubMedPubMedCentral Kakodkar P, Kaka N, Baig M. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19). Cureus. 2020;12(4):e7560.PubMedPubMedCentral
12.
go back to reference Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–3.PubMedPubMedCentralCrossRef Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270–3.PubMedPubMedCentralCrossRef
13.
go back to reference Astuti I, Ysrafil. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): an overview of viral structure and host response. Diabetes Metab Syndr. 2020;14(4):407–12.PubMedPubMedCentralCrossRef Astuti I, Ysrafil. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): an overview of viral structure and host response. Diabetes Metab Syndr. 2020;14(4):407–12.PubMedPubMedCentralCrossRef
14.
go back to reference Luan J, Lu Y, Jin X, Zhang L. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection. BiochemBiophys Res Commun. 2020;526(1):165–9.CrossRef Luan J, Lu Y, Jin X, Zhang L. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection. BiochemBiophys Res Commun. 2020;526(1):165–9.CrossRef
16.
go back to reference Kang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, et al. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharmaceutica Sin B. 2020;81:181. Kang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, et al. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Acta Pharmaceutica Sin B. 2020;81:181.
18.
go back to reference Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80.e8.PubMedPubMedCentralCrossRef Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–80.e8.PubMedPubMedCentralCrossRef
19.
20.
go back to reference Abdel-Moneim AS, Abdelwhab EM. Evidence for SARS-CoV-2 infection of animal hosts. Pathogens (Basel, Switzerland). 2020;9(7):529. Abdel-Moneim AS, Abdelwhab EM. Evidence for SARS-CoV-2 infection of animal hosts. Pathogens (Basel, Switzerland). 2020;9(7):529.
21.
go back to reference Li X, Zai J, Zhao Q, Nie Q, Li Y, Foley BT, et al. Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2. J Med Virol. 2020;92:602.CrossRefPubMed Li X, Zai J, Zhao Q, Nie Q, Li Y, Foley BT, et al. Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2. J Med Virol. 2020;92:602.CrossRefPubMed
23.
24.
go back to reference Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmunity. 2020;109:102433.CrossRef Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmunity. 2020;109:102433.CrossRef
25.
go back to reference Temmam S, Barbarino A, Maso D, Behillil S, Enouf V, Huon C, et al. Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus. bioRxiv. 2020;10:2315. Temmam S, Barbarino A, Maso D, Behillil S, Enouf V, Huon C, et al. Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus. bioRxiv. 2020;10:2315.
27.
28.
go back to reference Setti L, Passarini F, Gennaro GD, Barbieri P, Perrone MG, Borelli M, et al. Airborne transmission route of COVID-19: why 2 meters/6 feet of inter-personal distance could not be enough. IJERPH. 2020;17:2932.CrossRefPubMedCentral Setti L, Passarini F, Gennaro GD, Barbieri P, Perrone MG, Borelli M, et al. Airborne transmission route of COVID-19: why 2 meters/6 feet of inter-personal distance could not be enough. IJERPH. 2020;17:2932.CrossRefPubMedCentral
29.
go back to reference Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA. 2020;323(16):1610–2.PubMedPubMedCentralCrossRef Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA. 2020;323(16):1610–2.PubMedPubMedCentralCrossRef
32.
39.
go back to reference Shi J, Wen Z, Zhong G, Yang H, Wang C, Huang B, et al. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2. Science. 2020;368:1016–20.PubMedPubMedCentralCrossRef Shi J, Wen Z, Zhong G, Yang H, Wang C, Huang B, et al. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2. Science. 2020;368:1016–20.PubMedPubMedCentralCrossRef
40.
go back to reference Sia SF, Yan LM, Chin AWH, Fung K, Choy KT, Wong AYL, et al. Pathogenesis and transmission of SARS-CoV-2 in golden hamsters. Nature. 2020;583(7818):834–8.PubMedCrossRefPubMedCentral Sia SF, Yan LM, Chin AWH, Fung K, Choy KT, Wong AYL, et al. Pathogenesis and transmission of SARS-CoV-2 in golden hamsters. Nature. 2020;583(7818):834–8.PubMedCrossRefPubMedCentral
42.
go back to reference Richard M, Kok A, de Meulder D, Bestebroer TM, Lamers MM, Okba NM, et al. SARS-CoV-2 is transmitted via contact and via the air between ferrets. bioRxiv. 2020;11:3496. Richard M, Kok A, de Meulder D, Bestebroer TM, Lamers MM, Okba NM, et al. SARS-CoV-2 is transmitted via contact and via the air between ferrets. bioRxiv. 2020;11:3496.
43.
go back to reference Schlottau K, Rissmann M, Graaf A, Schön J, Sehl J, Wylezich C, et al. SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study. Lancet Microbe. 2020;1:e218–e225225.PubMedPubMedCentralCrossRef Schlottau K, Rissmann M, Graaf A, Schön J, Sehl J, Wylezich C, et al. SARS-CoV-2 in fruit bats, ferrets, pigs, and chickens: an experimental transmission study. Lancet Microbe. 2020;1:e218–e225225.PubMedPubMedCentralCrossRef
44.
go back to reference Freuling CM, Breithaupt A, Mueller T, Sehl J, Balkema-Buschmann A, Rissmann M, et al. Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection. bioRxiv. 2020:2020.08.19.256800. Freuling CM, Breithaupt A, Mueller T, Sehl J, Balkema-Buschmann A, Rissmann M, et al. Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection. bioRxiv. 2020:2020.08.19.256800.
47.
go back to reference Oreshkova N, Molenaar RJ, Vreman S, Harders F, Munnink BBO, Hakze-van der Honing RW, et al. SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020. Eurosurveillance. 2020;25(23):2001005.PubMedCentralCrossRef Oreshkova N, Molenaar RJ, Vreman S, Harders F, Munnink BBO, Hakze-van der Honing RW, et al. SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020. Eurosurveillance. 2020;25(23):2001005.PubMedCentralCrossRef
50.
go back to reference Yu P, Qi F, Xu Y, Li F, Liu P, Liu J, et al. Age-related rhesus macaque models of COVID-19. Anim Models Exp Med. 2020;3(1):93–7.CrossRef Yu P, Qi F, Xu Y, Li F, Liu P, Liu J, et al. Age-related rhesus macaque models of COVID-19. Anim Models Exp Med. 2020;3(1):93–7.CrossRef
51.
go back to reference Munster VJ, Feldmann F, Williamson BN, van Doremalen N, Pérez-Pérez L, Schulz J, et al. Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. Nature. 2020;60:389. Munster VJ, Feldmann F, Williamson BN, van Doremalen N, Pérez-Pérez L, Schulz J, et al. Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. Nature. 2020;60:389.
52.
go back to reference Cross RW, Agans KN, Prasad AN, Borisevich V, Woolsey C, Deer DJ, et al. Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase. Virol J. 2020;17(1):1–12.CrossRef Cross RW, Agans KN, Prasad AN, Borisevich V, Woolsey C, Deer DJ, et al. Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase. Virol J. 2020;17(1):1–12.CrossRef
53.
go back to reference Gretebeck LM, Subbarao K. Animal models for SARS and MERS coronaviruses. CurrOpinVirol. 2015;13:123–9. Gretebeck LM, Subbarao K. Animal models for SARS and MERS coronaviruses. CurrOpinVirol. 2015;13:123–9.
54.
go back to reference de Wit E, Feldmann F, Cronin J, Jordan R, Okumura A, Thomas T, et al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. ProcNatlAcadSci. 2020;117(12):6771–6.CrossRef de Wit E, Feldmann F, Cronin J, Jordan R, Okumura A, Thomas T, et al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. ProcNatlAcadSci. 2020;117(12):6771–6.CrossRef
55.
go back to reference Stittelaar KJ, De Waal L, Van Amerongen G, VeldhuisKroeze EJ, Fraaij PL, Van Baalen CA, et al. Ferrets as a novel animal model for studying human respiratory syncytial virus infections in immunocompetent and immunocompromised hosts. Viruses. 2016;8(6):168.PubMedCentralCrossRef Stittelaar KJ, De Waal L, Van Amerongen G, VeldhuisKroeze EJ, Fraaij PL, Van Baalen CA, et al. Ferrets as a novel animal model for studying human respiratory syncytial virus infections in immunocompetent and immunocompromised hosts. Viruses. 2016;8(6):168.PubMedCentralCrossRef
56.
go back to reference Zhang Q, Shi J, Deng G, Guo J, Zeng X, He X, et al. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science. 2013;341(6144):410–4.PubMedCrossRef Zhang Q, Shi J, Deng G, Guo J, Zeng X, He X, et al. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science. 2013;341(6144):410–4.PubMedCrossRef
57.
go back to reference OIE. Infection with SARS-COV-2 in animals. Technical fact sheet. 2020. OIE. Infection with SARS-COV-2 in animals. Technical fact sheet. 2020.
58.
go back to reference Zhong L, Chuan J, Gong B, Shuai P, Zhou Y, Zhang Y, et al. Detection of serum IgM and IgG for COVID-19 diagnosis. Sci China Life Sci. 2020;63(5):777–80.PubMedCrossRef Zhong L, Chuan J, Gong B, Shuai P, Zhou Y, Zhang Y, et al. Detection of serum IgM and IgG for COVID-19 diagnosis. Sci China Life Sci. 2020;63(5):777–80.PubMedCrossRef
59.
go back to reference Younes N, Al-Sadeq DW, Al-Jighefee H, Younes S, Al-Jamal O, Daas HI, et al. Challenges in laboratory diagnosis of the novel coronavirus SARS-CoV-2. Viruses. 2020;12(6):582.PubMedCentralCrossRef Younes N, Al-Sadeq DW, Al-Jighefee H, Younes S, Al-Jamal O, Daas HI, et al. Challenges in laboratory diagnosis of the novel coronavirus SARS-CoV-2. Viruses. 2020;12(6):582.PubMedCentralCrossRef
60.
go back to reference Gasmi A, Noor S, Tippairote T, Dadar M, Menzel A, Bjørklund G. Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic. ClinImmunol (Orlando, Fla). 2020;215:108409.CrossRef Gasmi A, Noor S, Tippairote T, Dadar M, Menzel A, Bjørklund G. Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic. ClinImmunol (Orlando, Fla). 2020;215:108409.CrossRef
61.
go back to reference Lipsitch M, Swerdlow DL, Finelli L. Defining the epidemiology of Covid-19-studies needed. N Engl J Med. 2020;382(13):1194–6.PubMedCrossRef Lipsitch M, Swerdlow DL, Finelli L. Defining the epidemiology of Covid-19-studies needed. N Engl J Med. 2020;382(13):1194–6.PubMedCrossRef
62.
go back to reference Hellewell J, Abbott S, Gimma A, Bosse NI, Jarvis CI, Russell TW, et al. Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts. Lancet Glob Health. 2020;8(4):e488–e496496.PubMedPubMedCentralCrossRef Hellewell J, Abbott S, Gimma A, Bosse NI, Jarvis CI, Russell TW, et al. Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts. Lancet Glob Health. 2020;8(4):e488–e496496.PubMedPubMedCentralCrossRef
Metadata
Title
COVID-19 pandemic: current knowledge about the role of pets and other animals in disease transmission
Authors
Mulugeta Kiros
Henok Andualem
Teklehaimanot Kiros
Wasihun Hailemichael
Sisay Getu
Alene Geteneh
Derbie Alemu
Woldaregay Erku Abegaz
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2020
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-020-01416-9

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